The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?

npj Parkinson s Disease, Год журнала: 2017, Номер 3(1)

Опубликована: Янв. 11, 2017

Abstract The state of the intestinal environment can have profound effects on activity central nervous system through physiological contributions microbiota, regulation barrier function, and altered peripheral neurons. common language employed for much gut-brain communication is modulation immune activity. Chronic proinflammatory increasingly being recognized as a fundamental element neurodegenerative disorders, in Parkinson’s disease, inflammation intestine appears particularly relevant pathogenesis. We review evidence that dysfunction present disease it may reflect earliest manifestations pathology, we link these findings to dysregulated Based this, model pathogenesis which disorder originates progresses with its underlying mechanism. More in-depth investigations into mechanisms pre-motor symptoms are expected lead development novel diagnostic therapeutic measures slow or limit progression more advanced stages involving debilitating motor cognitive symptoms.

Язык: Английский

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Anti‐inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation

The Journal of Physiology, Год журнала: 2016, Номер 594(20), С. 5781 - 5790

Опубликована: Апрель 10, 2016

Brain and viscera interplay within the autonomic nervous system where vagus nerve (VN), containing approximately 80% afferent 20% efferent fibres, plays multiple key roles in homeostatic regulations of visceral functions. Recent data have suggested anti-inflammatory role VN. This vagal function is mediated through several pathways, some them still debated. The first one hypothalamic-pituitary-adrenal axis which stimulated by fibres leads to release cortisol adrenal glands. second one, called cholinergic pathway, that synapse onto enteric neurons acetylcholine (ACh) at synaptic junction with macrophages. ACh binds α-7-nicotinic receptors those macrophages inhibit tumour necrosis (TNF)α, a pro-inflammatory cytokine. last pathway splenic sympathetic VN stimulates nerve. Norepinephrine (noradrenaline) released distal end links β2 adrenergic receptor lymphocytes ACh. Finally, inhibits TNFα spleen receptors. Understanding these pathways interesting from therapeutic point view, since they could be targeted various ways stimulate regulation TNFα-related diseases such as inflammatory bowel disease rheumatoid arthritis. Among others, stimulation, either an invasive or non-invasive procedure, becoming increasingly frequent clinical trials are ongoing evaluate potential effectiveness this therapy alleviate chronic inflammation.

Язык: Английский

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Neural regulation of immunity: molecular mechanisms and clinical translation

Nature Neuroscience, Год журнала: 2017, Номер 20(2), С. 156 - 166

Опубликована: Янв. 16, 2017

Язык: Английский

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Molecular and Functional Neuroscience in Immunity

Annual Review of Immunology, Год журнала: 2018, Номер 36(1), С. 783 - 812

Опубликована: Апрель 20, 2018

The nervous system regulates immunity and inflammation. molecular detection of pathogen fragments, cytokines, other immune molecules by sensory neurons generates immunoregulatory responses through efferent autonomic neuron signaling. functional organization this neural control is based on principles reflex regulation. Reflexes involving the vagus nerve nerves have been therapeutically explored in models inflammatory autoimmune conditions, recently clinical settings. brain integrates neuro-immune communication, function altered diseases characterized peripheral dysregulation Here we review anatomical basis interface with immunity, focusing functions role model immunological homunculus. Clinical advances stemming from knowledge within framework bioelectronic medicine are also briefly outlined.

Язык: Английский

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Dysbiosis of gut microbiota and microbial metabolites in Parkinson’s Disease

Ageing Research Reviews, Год журнала: 2018, Номер 45, С. 53 - 61

Опубликована: Апрель 26, 2018

Язык: Английский

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Multifaceted interactions between adaptive immunity and the central nervous system

Science, Год журнала: 2016, Номер 353(6301), С. 766 - 771

Опубликована: Авг. 18, 2016

Neuroimmunologists seek to understand the interactions between central nervous system (CNS) and immune system, both under homeostatic conditions in diseases. Unanswered questions include those relating diversity specificity of meningeal T cell repertoire; routes taken by cells that patrol meninges healthy invade parenchyma during pathology; opposing effects (beneficial or detrimental) these on CNS function; role after injury; evolutionary link two systems, resulting their tight interaction interdependence. This Review summarizes current standing challenging related adaptive immunity considers possible directions which aspects neuroimmunology will be heading over next decade.

Язык: Английский

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The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation

Gastroenterology, Год журнала: 2016, Номер 152(4), С. 730 - 744

Опубликована: Дек. 15, 2016

Although the gastrointestinal tract contains intrinsic neural plexuses that allow a significant degree of independent control over functions, central nervous system provides extrinsic inputs modulate, regulate, and integrate these functions. In particular, vagus nerve parasympathetic innervation to tract, coordinating complex interactions between peripheral mechanisms. This review discusses physiological roles afferent (sensory) motor (efferent) in regulation appetite, mood, immune system, as well pathophysiological outcomes dysfunction resulting obesity, mood disorders, inflammation. The therapeutic potential modulation attenuate or reverse restore autonomic homeostasis is also discussed.

Язык: Английский

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NGF and Its Receptors in the Regulation of Inflammatory Response

International Journal of Molecular Sciences, Год журнала: 2017, Номер 18(5), С. 1028 - 1028

Опубликована: Май 11, 2017

There is growing interest in the complex relationship between nervous and immune systems how its alteration can affect homeostasis result development of inflammatory diseases. A key mediator cross-talk two nerve growth factor (NGF), which influence both neuronal cell function activity. The up-regulation NGF described inflamed tissues many diseases regulate innervation activity peripheral neurons, inducing release immune-active neuropeptides neurotransmitters, but also directly innate adaptive responses. Expression receptors tropomyosin receptor kinase (TrkA) p75 neurotrophin (p75NTR) dynamically regulated cells, suggesting a varying requirement for depending on their state differentiation functional has variety effects that be either pro-inflammatory or anti-inflammatory. This apparent contradiction explained by considering as part an endogenous mechanism that, while activating responses, activates pathways necessary to dampen response limit tissue damage. Decreases TrkA expression, such recently demonstrated cells arthritis patients, might prevent activation regulatory feed-back mechanisms, thus contributing maintenance chronic inflammation.

Язык: Английский

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Cholinergic modulation of the immune system presents new approaches for treating inflammation

Pharmacology & Therapeutics, Год журнала: 2017, Номер 179, С. 1 - 16

Опубликована: Май 18, 2017

Язык: Английский

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Breath of Life: The Respiratory Vagal Stimulation Model of Contemplative Activity

Frontiers in Human Neuroscience, Год журнала: 2018, Номер 12

Опубликована: Окт. 9, 2018

Contemplative practices, such as meditation and yoga, are increasingly popular among the general public topics of research. Beneficial effects associated with these practices have been found on physical health, mental health cognitive performance. However, studies theories that clarify underlying mechanisms lacking or scarce. This theoretical review aims to address compensate this scarcity. We will show various contemplative activities in common breathing is regulated attentively guided. respiratory discipline turn could parsimoniously explain benefits through changes autonomic balance. propose a neurophysiological model explains how specific respiration styles operate, by phasically tonically stimulating vagal nerve: nerve stimulation (rVNS). The nerve, proponent parasympathetic nervous system (PNS), prime candidate explaining cognition. discuss implications limitations our model.

Язык: Английский

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