Biochemical and Biophysical Research Communications, Год журнала: 2018, Номер 503(3), С. 1342 - 1348
Опубликована: Июль 17, 2018
Язык: Английский
Biochemical and Biophysical Research Communications, Год журнала: 2017, Номер 490(2), С. 406 - 414
Опубликована: Июнь 14, 2017
Язык: Английский
Процитировано
267
Molecular Cancer, Год журнала: 2018, Номер 17(1)
Опубликована: Окт. 3, 2018
Extracellular communication within the tumor microenvironment plays a critical role in progression. Although exosomes can package into long non-coding RNAs (lncRNAs) to mediate extracellular communication, of exosomal lncRNA PTENP1 bladder cancer (BC) remains unclear. We detected expression between patients with BC and healthy controls; occurred tissues from plasma. assessed diagnostic accuracy by receiver operating characteristic curve (ROC) area under (AUC). Cell phenotypes animal experiments were performed determine effect PTENP1. was significantly reduced plasma (P < 0.05). found that mainly wrapped exosomes. Exosomal could distinguish controls (AUC = 0.743; 95% confidence interval (CI) 0.645–0.840). Normal cells secreted transmitted it cells, thus inhibiting biological malignant behavior increasing cell apoptosis reducing ability invade migrate suppress growth vivo. Furthermore, mediated PTEN competitively binding microRNA-17. is promising novel biomarker be used for clinical detection BC. Exosomes derived normal transfer which reduce progression both vitro vivo suggest participates normal-cell-to-bladder-cell during carcinogenesis
Язык: Английский
Процитировано
254
Pathology - Research and Practice, Год журнала: 2023, Номер 249, С. 154738 - 154738
Опубликована: Авг. 6, 2023
Язык: Английский
Процитировано
68
Molecular Oncology, Год журнала: 2018, Номер 12(5), С. 648 - 658
Опубликована: Март 5, 2018
Lung cancer is the first leading cause of deaths worldwide. Non‐small cell lung (NSCLC) most common type cancer. Increasing evidence shows that long noncoding RNA (lncRNA) are capable modulating tumor initiation, proliferation and metastasis. In present study, we aimed to evaluate whether circulating lncRNA could be used as biomarkers for diagnosis prognosis NSCLC. Expression profiles 14 selected from other studies were validated in 20 pairs tissues by quantitative real‐time PCR, dysregulated thus identified further serum samples two independent cohorts along with three makers (CEA, CYFRA21‐1, SCCA). Receiver‐operating characteristic analysis was utilized estimate diagnostic efficiency candidate markers. Importantly, observed an association between expression overall survival (OS) rate The expressions SOX2 overlapping transcript (SOX2OT) ANRIL obviously upregulated NSCLC compared normal controls ( P < 0.01). Based on data training set, next a logistic regression model construct panel consisting area under curve this 0.853 (95% confidence interval = 0.804–0.894, sensitivity 77.1%, specificity 79.2%), distinctly superior any biomarker alone (all at 0.05). Similar results validation set. Intriguingly, Kaplan–Meier demonstrated low SOX2OT both associated higher OS 0.008 0.017, respectively), prognostic factor 0.036). Taken together, our study newly developed SOX2OT, ANRIL, CEA, SCCA valuable diagnosis. LncRNA might ideal prognosis.
Язык: Английский
Процитировано
139
Clinica Chimica Acta, Год журнала: 2018, Номер 486, С. 26 - 33
Опубликована: Июль 17, 2018
Язык: Английский
Процитировано
108
Frontiers in Oncology, Год журнала: 2019, Номер 9
Опубликована: Окт. 2, 2019
Colorectal cancer (CRC) is a common malignancy with 1. 8 million cases in 2018. Autophagy helps to maintain an adequate microenvironment order provide nutritional supplement under adverse conditions such as starvation and hypoxia. Additionally, most of the CRC are unresponsive chemotherapy, representing significant challenge for therapy. Recently, autophagy induced by therapy has been shown unique mechanism resistance anticancer drugs. In this regard, long non-coding RNAs (lncRNAs) analysis important detection, progression, diagnosis, response, prognostic values. With increasing development quantitative detection techniques, lncRNAs derived from patients' non-invasive samples (i.e., blood, stools, urine) become into novel approach precision oncology. Tumorspecific GAS5, HOTAIR, H19, MALAT novels related detected patients. Nonetheless, effect chemoresistance have not extensively characterized. Chemoresistance relevant treatment play pivotal role acquisition several LncRNAs HAGLROS, KCNQ1OT1, H19 examples leaded autophagy. Finally, clinical implications relevant, since they associated tumor differentiation, size, histological grade, types, Dukes staging, degree lymph node metastasis, distant recurrent free survival, overall survival (OS).
Язык: Английский
Процитировано
108
Oncotarget, Год журнала: 2017, Номер 8(42), С. 73282 - 73295
Опубликована: Авг. 4, 2017
// Yuqing He 1, 3, * , Yanhong Luo 2, Biyu Liang Lei Ye 2 Guangxing Lu and Weiming 1 Institute of Medical Systems Biology, Guangdong University, Dongguan 523808, China Department Epidemiology Statistics, 3 Key Laboratory for Molecular Diagnostics Province, Authors contributed equally to this work Correspondence to: He, email: [email protected] Keywords: cancer, long noncoding RNAs, maternally expressed gene apoptosis, MEG3 Received: June 01, 2017 Accepted: July 25, Published: August 04, 2017 ABSTRACT LncRNAs are emerging as integral functional regulatory components normal biological activities now considered critically involved in the development different diseases including cancer. In review, we summarized recent findings on (MEG3), a lncRNA, locates imprinted DLK1–MEG3 locus human chromosome 14q32.3 region. is tissues but either lost or decreased many tumors tumor derived cell lines. Studies have demonstrated that associated with cancer initiation, progression, metastasis chemo-resistance. may affect TP53, MDM2, GDF15, RB1 some other key cycle regulators. addition, level showed good correlation clinicopathological grade. summary, MEGs an RNA-based suppressor etiology, chemosensitivity cancers. The alteration levels various cancers suggested possibility using diagnosis prognosis.
Язык: Английский
Процитировано
107
OncoTargets and Therapy, Год журнала: 2018, Номер Volume 11, С. 8045 - 8052
Опубликована: Ноя. 1, 2018
Abstract: Lung cancer has been identified as one of the most prevalent and deadly tumors worldwide. In recent years, lncRNAs have demonstrated to play a significant role in development lung cancer. Specifically, act regulator cancer-critical genes, they regulate biological behavior at transcriptional posttranscriptional levels. Recent studies shown that possess great potential treatment non-small cell patients because their roles diverse cellular processes, such proliferation, metastasis, stem maintenance, epithelial mesenchymal transition, serve signaling biomarkers. Compared other invasive diagnostic methods, detection may become very useful noninvasive methodology. Moreover, can therapeutic targets due regulating many pathways associated with carcinoma. this review, we discuss expression profile lncRNAs. We also promising application predictors clinical diagnosis, prognosis, targets, aiming demonstrate practical value for treatment. Keywords: biomarker, lncRNA, therapy, NSCLC
Язык: Английский
Процитировано
90
Cell Death Discovery, Год журнала: 2022, Номер 8(1)
Опубликована: Авг. 13, 2022
Abstract Lung cancer has been one of the leading causes cancer-related death worldwide, and non-small-cell lung (NSCLC) accounts for majority morbidity, yet pathogenesis NSCLC not fully elucidated. Recently, long-chain non-coding RNA (lncRNA) attracted widespread attention. LncRNA is a type whose transcript length exceeds 200 nucleotides. After constant research, academics updated their understanding lncRNA, especially its role in biological processes cells, including epigenetic regulation, cell proliferation, differentiation. Notably, examination lncRNAs could serve as potential hallmarks clinicopathological features, long-term prognosis, drug sensitivity. Therefore, it necessary to explore functions lncRNA innovate strategies against based on lncRNA-related research. Herein, we reviewed occurrence, diagnosis, treatment, prognosis NSCLC, which only help promote comprehensive view but also shed light lncRNA-based diagnosis treatment NSCLC.
Язык: Английский
Процитировано
48
Non-coding RNA Research, Год журнала: 2024, Номер 9(3), С. 831 - 852
Опубликована: Март 31, 2024
Non-coding RNAs (ncRNAs) are a diverse group of functional RNA molecules that lack the ability to code for proteins. Despite missing this traditional role, ncRNAs have emerged as crucial regulators various biological processes and been implicated in development progression many diseases, including cancer. MicroRNAs (miRNAs) long non-coding (lncRNAs) two prominent classes key players cancer pathophysiology. In particular, miR-21 has reported exhibit oncogenic roles forms human cancer, prostate, breast, lung, colorectal context, overexpression is closely associated with tumor proliferation, growth, invasion, angiogenesis, chemoresistance, whereas inactivation linked regression most tumor-related processes. Accordingly, modulator canonical pathways such PTEN/PI3K/Akt, Wnt/β-catenin, STAT, p53, MMP2, MMP9. Moreover, interplays between lncRNA miRNA further complicate regulatory mechanisms underlying progression. regard, several lncRNAs found interact and, by functioning competitive endogenous (ceRNAs) or sponges, can modulate tumorigenesis. This work presents discusses recent findings highlighting pathophysiological implications miR-21-lncRNA axis occurrence, development, The data collected indicate specific lncRNAs, MEG3, CASC2, GAS5, strongly types gastric, cervical, glioma. Indeed, these well-known suppressors commonly downregulated different tumors. Conversely, modulating signaling pathways, their preventing formation development. review highlights significance potential use therapy diagnostic prognostic markers.
Язык: Английский
Процитировано
9