Future Oncology,
Год журнала:
2021,
Номер
17(15), С. 1943 - 1961
Опубликована: Март 17, 2021
Tumors
are
equipped
with
a
highly
complex
machinery
of
interrelated
events
so
as
to
adapt
hazardous
conditions,
preserve
growing
cell
mass
and
thrive
at
the
site
metastasis.
Tumor
cells
display
metastatic
propensity
toward
specific
organs
where
stromal
milieu
is
appropriate
for
their
further
colonization.
Effective
colonization
relies
on
plasticity
tumor
in
adapting
conditions
new
area
by
reshaping
epigenetic
landscape.
Breast
cancer
cells,
instance,
able
adopt
brain-like
or
epithelial/osteoid
features
order
pursue
effective
metastasis
into
brain
bone,
respectively.
The
aim
this
review
discuss
recent
insights
organ
tropism
metastasis,
outlining
potential
strategies
address
driver
aggressiveness.
Nutrients,
Год журнала:
2021,
Номер
13(8), С. 2594 - 2594
Опубликована: Июль 28, 2021
Propolis
is
a
natural
material
that
honey
bees
(Apis mellifera)
produce
from
various
botanical
sources.
The
therapeutic
activity
of
propolis,
including
antibacterial,
antifungal,
and
anti-inflammatory
effects,
have
been
known
since
antiquity.
Cancer
one
the
major
burdens
disease
worldwide,
therefore,
numerous
studies
are
being
conducted
to
develop
new
chemotherapeutic
agents
treatments
for
cancer.
rich
source
biologically
active
compounds,
which
affect
signaling
pathways
regulating
crucial
cellular
processes.
results
latest
research
show
propolis
can
inhibit
proliferation,
angiogenesis,
metastasis
cancer
cells
stimulate
apoptosis.
Moreover,
it
may
influence
tumor
microenvironment
multidrug
resistance
cancers.
This
review
briefly
summarizes
molecular
mechanisms
anticancer
its
compounds
highlights
potential
benefits
reduce
side
effects
chemotherapy
radiotherapy.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июль 5, 2024
Abstract
Cancer
stem
cells
(CSCs),
a
small
subset
of
in
tumors
that
are
characterized
by
self-renewal
and
continuous
proliferation,
lead
to
tumorigenesis,
metastasis,
maintain
tumor
heterogeneity.
continues
be
significant
global
disease
burden.
In
the
past,
surgery,
radiotherapy,
chemotherapy
were
main
cancer
treatments.
The
technology
treatments
develop
advance,
emergence
targeted
therapy,
immunotherapy
provides
more
options
for
patients
certain
extent.
However,
limitations
efficacy
treatment
resistance
still
inevitable.
Our
review
begins
with
brief
introduction
historical
discoveries,
original
hypotheses,
pathways
regulate
CSCs,
such
as
WNT/β-Catenin,
hedgehog,
Notch,
NF-κB,
JAK/STAT,
TGF-β,
PI3K/AKT,
PPAR
pathway,
their
crosstalk.
We
focus
on
role
CSCs
various
therapeutic
outcomes
resistance,
including
how
affect
content
alteration
related
molecules,
CSCs-mediated
clinical
value
targeting
refractory,
progressed
or
advanced
tumors.
summary,
efficacy,
method
is
difficult
determine.
Clarifying
regulatory
mechanisms
biomarkers
currently
mainstream
idea.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Сен. 2, 2024
Abstract
The
primary
reason
for
high
mortality
rates
among
cancer
patients
is
metastasis,
where
tumor
cells
migrate
through
the
bloodstream
from
original
site
to
other
parts
of
body.
Recent
advancements
in
technology
have
significantly
enhanced
our
comprehension
mechanisms
behind
bloodborne
spread
circulating
(CTCs).
One
critical
process,
DNA
methylation,
regulates
gene
expression
and
chromosome
stability,
thus
maintaining
dynamic
equilibrium
Global
hypomethylation
locus-specific
hypermethylation
are
examples
changes
methylation
patterns
that
pivotal
carcinogenesis.
This
comprehensive
review
first
provides
an
overview
various
processes
contribute
formation
CTCs,
including
epithelial-mesenchymal
transition
(EMT),
immune
surveillance,
colonization.
We
then
conduct
in-depth
analysis
how
modifications
within
CTCs
impact
each
these
stages
during
CTC
dissemination.
Furthermore,
we
explored
potential
clinical
implications
with
cancer.
By
understanding
epigenetic
modifications,
can
gain
insights
into
metastatic
process
identify
new
biomarkers
early
detection,
prognosis,
targeted
therapies.
aims
bridge
gap
between
basic
research
application,
highlighting
significance
context
metastasis
offering
avenues
improving
patient
outcomes.
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2021,
Номер
35(11)
Опубликована: Авг. 31, 2021
Abstract
Solid
cancers
comprise
a
large
number
of
new
cases
and
deaths
from
cancer
each
year
globally.
There
are
strategies
for
addressing
tumors
raised
solid
organs
including
surgery,
chemotherapy,
radiotherapy,
targeted
therapy,
immunotherapy,
combinational
stem
cell
extracellular
vesicle
(EV)
therapy.
Surgery,
chemotherapy
the
dominant
cures,
but
not
always
effective,
in
which
even
localized
tumor
there
is
possibility
relapse
after
surgical
resection.
Over
half
patients
will
receive
radiotherapy
as
part
their
therapeutic
schedule.
Radiotherapy
can
cause
an
abscopal
response
boosting
activity
immune
system
outside
local
field
radiation,
it
may
also
unwanted
bystander
effect,
predisposing
nonradiated
cells
into
carcinogenesis.
In
context
checkpoint
inhibition
known
standard‐of‐care,
major
concern
regard
with
cold
that
show
low
responses
to
such
Stem‐cell
therapy
be
used
send
prodrugs
toward
area;
this
strategy,
however,
has
its
own
predicaments,
attraction
other
sites
healthy
tissues
instability.
A
substitute
quite
novel
strategy
use
EVs,
by
virtue
stability
potential
cross
biological
barriers
long‐term
storage
contents.
Combination
current
focus.
Despite
advances
field,
still
unmet
concerns
area
effective
raising
challenges
opportunities
future
investigations.
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2021,
Номер
35(4)
Опубликована: Янв. 24, 2021
Abstract
Cold
tumors
generally
show
low
mutational
burden
and
infiltration
of
effector
T
cells.
The
pancreas,
prostate,
ovary,
breast,
colon
are
placed
into
the
category
cold
tumors.
In
such
tumors,
cells
either
excluded
from
tumor
area
or
taken
away
being
in
contact
with
stromal
reaction
form
desmoplasia
is
important
for
pathogenesis
like
pancreas.
Besides
acting
as
a
barrier
penetration
drugs
area,
dense
stroma
presumably
creates
an
immunosuppressive
microenvironment
(TME),
which
accounts
responses
to
immunotherapy.
Cancer
stem
(CSCs)
part
complex
within
TME.
presence
CSCs
TME
related
negatively
activity
antitumor
immune
system.
Here,
question
how
desmoplastic
aggregates
can
influence
functionality
promoting
pancreatic
immunity?
This
review
aimed
at
responding
this
question,
disruption
be
effective
strategy
improving
