Circulating tumor cells in the early detection of human cancers DOI Creative Commons

Zixin Feng,

Junyu Wu, Yuanjun Lu

et al.

International Journal of Biological Sciences, Journal Year: 2022, Volume and Issue: 18(8), P. 3251 - 3265

Published: Jan. 1, 2022

Cancer is a severe disease with high morbidity and mortality globally.Thus, early detection emerging as an important topic in modern oncology.Although the strategies for have developed rapidly recent decades, they remain challenging due to subtle symptoms initial stage of primary tumor.Currently, tumor biomarkers, imaging, specific screening tests are widely used various cancer types; however, each method has limitations.The harms even overweight against benefits some cases.Therefore, approaches should be improved urgently.Liquid biopsy, now, convenient non-invasive way compared traditional tissue biopsy diagnosis.Circulating cells (CTCs) vital liquid play central role dissemination metastases.They promising potential biomarkers detection.This review updates knowledge biology CTC; it also highlights CTC enrichment technologies their applications several human cancers.

Language: Английский

Angiogenesis as a hallmark of solid tumors - clinical perspectives DOI
Jamal Majidpoor, Keywan Mortezaee

Cellular Oncology, Journal Year: 2021, Volume and Issue: 44(4), P. 715 - 737

Published: April 9, 2021

Language: Английский

Citations

191
The efficacy of PD-1/PD-L1 blockade in cold cancers and future perspectives DOI
Jamal Majidpoor, Keywan Mortezaee

Clinical Immunology, Journal Year: 2021, Volume and Issue: 226, P. 108707 - 108707

Published: March 1, 2021

Language: Английский

Citations

172
Cancer cell plasticity during tumor progression, metastasis and response to therapy DOI
Andrea Pérez-González, Kevin Bévant, Cédric Blanpain

et al.

Nature Cancer, Journal Year: 2023, Volume and Issue: 4(8), P. 1063 - 1082

Published: Aug. 3, 2023

Language: Английский

Citations

143
Anticancer Activity of Propolis and Its Compounds DOI
Ewa Forma, Magdalena Bryś

Nutrients, Journal Year: 2021, Volume and Issue: 13(8), P. 2594 - 2594

Published: July 28, 2021

Propolis is a natural material that honey bees (Apis mellifera) produce from various botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and anti-inflammatory effects, have been known since antiquity. Cancer one the major burdens disease worldwide, therefore, numerous studies are being conducted to develop new chemotherapeutic agents treatments for cancer. rich source biologically active compounds, which affect signaling pathways regulating crucial cellular processes. results latest research show propolis can inhibit proliferation, angiogenesis, metastasis cancer cells stimulate apoptosis. Moreover, it may influence tumor microenvironment multidrug resistance cancers. This review briefly summarizes molecular mechanisms anticancer its compounds highlights potential benefits reduce side effects chemotherapy radiotherapy.

Language: Английский

Citations

130
Cancer stem cells: advances in knowledge and implications for cancer therapy DOI Creative Commons

Xianjing Chu,

Wentao Tian,

Jiaoyang Ning

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 5, 2024

Abstract Cancer stem cells (CSCs), a small subset of in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, maintain tumor heterogeneity. continues be significant global disease burden. In the past, surgery, radiotherapy, chemotherapy were main cancer treatments. The technology treatments develop advance, emergence targeted therapy, immunotherapy provides more options for patients certain extent. However, limitations efficacy treatment resistance still inevitable. Our review begins with brief introduction historical discoveries, original hypotheses, pathways regulate CSCs, such as WNT/β-Catenin, hedgehog, Notch, NF-κB, JAK/STAT, TGF-β, PI3K/AKT, PPAR pathway, their crosstalk. We focus on role CSCs various therapeutic outcomes resistance, including how affect content alteration related molecules, CSCs-mediated clinical value targeting refractory, progressed or advanced tumors. summary, efficacy, method is difficult determine. Clarifying regulatory mechanisms biomarkers currently mainstream idea.

Language: Английский

Citations

85
Circulating tumor cells: from new biological insights to clinical practice DOI Creative Commons
Xuyu Gu, Shiyou Wei,

Xin Lv

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 2, 2024

Abstract The primary reason for high mortality rates among cancer patients is metastasis, where tumor cells migrate through the bloodstream from original site to other parts of body. Recent advancements in technology have significantly enhanced our comprehension mechanisms behind bloodborne spread circulating (CTCs). One critical process, DNA methylation, regulates gene expression and chromosome stability, thus maintaining dynamic equilibrium Global hypomethylation locus-specific hypermethylation are examples changes methylation patterns that pivotal carcinogenesis. This comprehensive review first provides an overview various processes contribute formation CTCs, including epithelial-mesenchymal transition (EMT), immune surveillance, colonization. We then conduct in-depth analysis how modifications within CTCs impact each these stages during CTC dissemination. Furthermore, we explored potential clinical implications with cancer. By understanding epigenetic modifications, can gain insights into metastatic process identify new biomarkers early detection, prognosis, targeted therapies. aims bridge gap between basic research application, highlighting significance context metastasis offering avenues improving patient outcomes.

Language: Английский

Citations

29
Pre-metastatic niche: formation, characteristics and therapeutic implication DOI Creative Commons
Yuhang Wang,

Jiachi Jia,

Fuqi Wang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 25, 2024

Language: Английский

Citations

22
VEGFA Gene Expression in Breast Cancer Is Associated With Worse Prognosis, but Better Response to Chemotherapy and Immunotherapy DOI Open Access

Pia Sharma,

Kohei Chida, Rongrong Wu

et al.

World Journal of Oncology, Journal Year: 2025, Volume and Issue: 16(1), P. 120 - 130

Published: Jan. 14, 2025

Vascular endothelial growth factor-A (VEGFA) is a key inducer of angiogenesis, responsible for generating new blood vessels in the tumor microenvironment (TME) and facilitating metastasis. Notably, Avastin, which targets VEGFA, failed to demonstrate any significant benefit clinical trials breast cancer (BC). This study aimed investigate relevance VEGFA gene expression BC. A total 7,336 BC patients across eight independent cohorts: ISPY2 (GSE173839), Sweden Cancerome Analysis Network-Breast (SCAN-B) (GSE96058), Molecular Taxonomy Breast Cancer International Consortium (METABRIC), GSE25066, GSE163882, GSE34138, GSE20194, The Genome Atlas (TCGA), were analyzed. calculated median level was used stratify these cohorts into high low groups. High associated with worse disease-free, disease-specific, overall survival METABRIC cohort, findings supported by SCAN-B also showed (all P < 0.02). seen triple-negative (TNBC) but not lymph node Additionally, there correlation between higher silent non-silent mutations, single-nucleotide variant (SNV) neoantigens, homologous recombination defect, intratumoral heterogeneity, TCGA cohort. In TCGA, METABRIC, cohorts, cell proliferation: Ki67 expression, Nottingham histological grade, consistent enrichment all Hallmark proliferation-related sets. Unexpectedly, angiogenesis set enriched no association infiltrations lymphatic or vascular cells besides pericytes. had significantly less infiltration anti-cancer immune pro-cancer cohorts. Interestingly, BC, pathological complete response (pCR) after anthracycline- taxane-based neoadjuvant therapy, heightened both estrogen receptor (ER)+/human epidermal factor 2 (HER2)- TNBC subtypes GSE25066 cohort immunotherapy ER+/ HER2- subtype, Our research indicates that confers proliferation, reduced infiltration, poorer survival, allows better chemotherapy, immunotherapy.

Language: Английский

Citations

2
The current knowledge concerning solid cancer and therapy DOI
Masoud Najafi, Jamal Majidpoor, Heidar Toolee

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2021, Volume and Issue: 35(11)

Published: Aug. 31, 2021

Abstract Solid cancers comprise a large number of new cases and deaths from cancer each year globally. There are strategies for addressing tumors raised solid organs including surgery, chemotherapy, radiotherapy, targeted therapy, immunotherapy, combinational stem cell extracellular vesicle (EV) therapy. Surgery, chemotherapy the dominant cures, but not always effective, in which even localized tumor there is possibility relapse after surgical resection. Over half patients will receive radiotherapy as part their therapeutic schedule. Radiotherapy can cause an abscopal response boosting activity immune system outside local field radiation, it may also unwanted bystander effect, predisposing nonradiated cells into carcinogenesis. In context checkpoint inhibition known standard‐of‐care, major concern regard with cold that show low responses to such Stem‐cell therapy be used send prodrugs toward area; this strategy, however, has its own predicaments, attraction other sites healthy tissues instability. A substitute quite novel strategy use EVs, by virtue stability potential cross biological barriers long‐term storage contents. Combination current focus. Despite advances field, still unmet concerns area effective raising challenges opportunities future investigations.

Language: Английский

Citations

93
Enriched cancer stem cells, dense stroma, and cold immunity: Interrelated events in pancreatic cancer DOI
Keywan Mortezaee

Journal of Biochemical and Molecular Toxicology, Journal Year: 2021, Volume and Issue: 35(4)

Published: Jan. 24, 2021

Abstract Cold tumors generally show low mutational burden and infiltration of effector T cells. The pancreas, prostate, ovary, breast, colon are placed into the category cold tumors. In such tumors, cells either excluded from tumor area or taken away being in contact with stromal reaction form desmoplasia is important for pathogenesis like pancreas. Besides acting as a barrier penetration drugs area, dense stroma presumably creates an immunosuppressive microenvironment (TME), which accounts responses to immunotherapy. Cancer stem (CSCs) part complex within TME. presence CSCs TME related negatively activity antitumor immune system. Here, question how desmoplastic aggregates can influence functionality promoting pancreatic immunity? This review aimed at responding this question, disruption be effective strategy improving

Language: Английский

Citations

79