Background
Metabolic
reprogramming
has
emerged
as
a
key
hallmark
of
cancer
progression,
though
its
role
in
tumor
aggressiveness
is
still
evolving.
Here,
using
pan-cancer
genome
approach,
we
aimed
to
comprehensively
assess
the
metabolic
involved
carcinomas
and
identify
hubs
which
can
be
therapeutically
targeted
treat
aggressive
tumors
clinic.
Methods
In
this
study,
employed
stringent
multi-omic
metabolism-targeted
differential
expression
approach
regulating
aggressiveness.
mRNA,
miRNA,
DNA
methylation
mutation
profiling
data
representing
14
different
types
was
downloaded
from
TCGA
database.
Cell
line
drug
response
CCLE
Pathway
enrichment,
GSEA,
String
protein-protein
interaction,
miRNA-mRNA
prediction,
network
random-walk
analyses
were
carried
out.
Results
We
identified
downregulated
enzymes
oxidative
phosphorylation
common
factor
across
carcinomas,
aligning
with
Warburg
effect.
Additionally,
established
that
decreased
dependence
on
driven
by
elevated
miR-199
family
miRNAs
inhibit
their
at
post-transcriptional
level.
Furthermore,
epithelial-to-mesenchymal
transition-related
transcription
factor,
TWIST1,
master
regulator
controlling
miR-199a-3p
-5p
expression.
Random
walk
analysis
NDUFA2,
DLD,
COX15,
NDUFB5,
TIMM13
crucial
become
aggressive.
Drug
suggested
targeting
PDGFR
signaling
may
offer
novel
therapeutic
counteract
loss
phosphorylation.
Conclusion
TWIST1/miR-199a
axis
mediated
suppression
major
contributor
towards
carcinomas.
These
insights
underscore
critical
interplay
between
aggressiveness,
opening
avenues
for
potential
therapies
clinical
settings.
Abstract
Aging
is
an
inevitable
physiological
process
in
organisms,
and
the
development
of
tumors
closely
associated
with
cellular
senescence.
This
article
initially
examines
role
senescence
tumorigenesis,
emphasizing
correlation
between
telomere
length—a
marker
senescence—and
tumor
risk.
Concurrently,
study
explores
expression
levels
senescence-associated
markers,
such
as
p16,
p53,
mTOR,
context
development.
Additionally,
investigates
impact
on
organismal
senescence,
including
effects
immune
system
function
metabolic
processes.
Ultimately,
discussion
potential
application
anti-aging
strategies
therapy
considers
possibility
utilizing
mechanisms
a
novel
therapeutic
approach
for
tumors.
research
provides
insights
into
complex
interplay
development,
suggesting
future
preventative
measures
interventions.
Nanotechnology Reviews,
Год журнала:
2025,
Номер
14(1)
Опубликована: Янв. 1, 2025
Abstract
Osteosarcoma
(OS)
is
the
most
frequent
primary
malignant
bone
tumor
in
adolescents
and
young
adults.
Despite
advances
therapy,
OS
remains
an
ominous
problem
because
of
its
high
metastatic
potential,
resistance
to
standard
great
physical,
psychological,
financial
burden
on
patients.
Available
treatment
options
like
surgery
high-dose
chemotherapy
are
limited
by
chemotoxicity,
multimed
resistance,
adverse
effects
quality
life
Extrapolated
from
wide
array
vitro
vivo
studies,
application
kinase
inhibitors
targeting
oncogenic
signaling
pathways,
such
as
insulin-like
growth
factor
1
receptor,
PDGFR,
PI3K/AKT/mTOR
pathway,
appears
quite
promising.
However,
patients
plagued
with
challenges
poor
bioavailability,
off-target
effects,
mechanisms,
which
prevent
clinical
application.
This
review
explores
how
nanotechnology
beginning
meet
these
challenges.
Liposomes,
polymeric
nanoparticles,
metallic
nanoparticles
among
that
provide
new
solutions
for
delivery
bioavailability
inhibitors,
reducing
systemic
toxicity
enhancing
therapeutic
accuracy.
Active
or
passive
enabled
nanocarriers,
enable
drugs
specifically
act
tissues
while
minimizing
healthy
cells.
Additionally,
diagnostic
functionalities
combined
into
theranostic
platforms
through
pave
way
personalized
medicine
approaches.
Nanoparticle-based
have
shown
efficacy
preclinical
setting
overcome
drug
improve
targeting,
sustained
release
drug.
These
dramatic
improving
outcomes
at
much
less
than
currently
available
treatments.
shows
need
further
exploration
bridge
exciting
findings
practice.
Future
studies
should
seek
optimize
nanoparticle
design
evade
enhance
target
specificity,
reduce
time-dependent
toxicity.
Further,
incorporation
a
strategy
has
possibility
changing
treated
bringing
promise
better
patient
life.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 17, 2024
Photoaffinity
labeling
is
a
widely
used
technique
for
studying
ligand-protein
and
protein-protein
interactions.
Traditional
photoaffinity
labels
utilize
nonspecific
C-H
bond
insertion
reactions
mediated
by
highly
reactive
intermediate.
Despite
being
the
most
labels,
diazirines
exhibit
limited
compatibility
with
downstream
organic
suffer
from
storage
stability
concerns.
This
study
introduces
oxadiazolines
as
innovative
complementary
photoactivatable
addition
to
toolbox
demonstrates
their
application
in
vitro
through
Journal of Applied Polymer Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
Abstract
Dasatinib
(DAS)
has
recently
gained
significant
interest
for
its
anticancer
potential.
Yet,
the
lipophilicity
inherent
in
DAS
limited
potential
use
as
a
chemotherapeutic
drug.
This
study
aimed
to
examine
effectiveness
of
polyethylene
glycol‐polycaprolactone
(PEG‐PCL)
nanocarrier
increase
capabilities.
The
DAS‐loaded
PEG‐PCL
nanoparticles
(termed
DAS@PEG‐PCL
NPs)
were
characterized
using
Fourier
transform
infrared
(FTIR),
scanning
electron
microscopy
(SEM),
transmission
(TEM),
and
dynamic
light
scattering
(DLS).
Morphological
staining
MTT
tests
employed
investigate
drug‐loaded
nanoparticles'
apoptotic
anti‐proliferative
effects.
assay
demonstrated
that
incorporating
onto
NPs
resulted
dose‐dependent
cytotoxicity
A549
(lung
cancer)
HeLa
(cervical
cells.
cancer
cells
analyzed
their
morphology
acridine
orange/ethidium
bromide
(AO/EB)
DAPI
techniques.
Overall,
these
findings
demonstrate
polymeric
nanoparticle
systems
hold
great
novel
therapeutic
strategy
treatment.
Pharmaceutics,
Год журнала:
2024,
Номер
16(11), С. 1428 - 1428
Опубликована: Ноя. 9, 2024
The
development
of
therapies
targeting
unregulated
Src
signaling
through
selective
kinase
inhibition
using
small-molecule
inhibitors
presents
a
significant
challenge
for
the
scientific
community.
Among
these
inhibitors,
pyrazolo[3,4-
