Unlocking cancer vaccine potential: What are the key factors?

Human Vaccines & Immunotherapeutics, Год журнала: 2024, Номер 20(1)

Опубликована: Апрель 2, 2024

Cancer is a global health challenge, with changing demographics and lifestyle factors producing an increasing burden worldwide. Screening advancements are enabling earlier diagnoses, but current cancer immunotherapies only induce remission in small proportion of patients come at high cost. vaccines may offer solution to these challenges, they have been mired by poor results past decades. Greater understanding tumor biology, coupled the success vaccine technologies during COVID-19 pandemic, has reinvigorated development. With first signs efficacy being reported, be beginning fulfill their potential. Solid tumors, however, present different hurdles than infectious diseases. Combining insights from previous clinical development contemporary knowledge immunology, we ask: who 'right' patients, what targets, which modalities maximize chances success?

Язык: Английский

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Advances in Therapeutic Cancer Vaccines, Their Obstacles, and Prospects Toward Tumor Immunotherapy

Molecular Biotechnology, Год журнала: 2024, Номер unknown

Опубликована: Апрель 16, 2024

Язык: Английский

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Recent Advances and Prospects of Nucleic Acid Therapeutics for Anti-Cancer Therapy

Molecules, Год журнала: 2024, Номер 29(19), С. 4737 - 4737

Опубликована: Окт. 7, 2024

Nucleic acid therapeutics are promising alternatives to conventional anti-cancer therapy, such as chemotherapy and radiation therapy. While therapies have limitations, high side effects, low specificity, drug resistance, nucleic work at the gene level eliminate cause of disease. treat diseases in various forms using different mechanisms, including plasmid DNA (pDNA), small interfering RNA (siRNA), anti-microRNA (anti-miR), microRNA mimics (miRNA mimic), messenger (mRNA), aptamer, catalytic (CNA), CRISPR cas9 guide (gRNA). In addition, acids many advantages nanomaterials, biocompatibility, design flexibility, immunogenicity, size, relatively price, easy functionalization. can a therapeutic effect by being used combination with nanostructures, inorganic nanoparticles, lipid nanoparticles (LNPs), etc. overcome physiological stability cell internalization efficiency. The field has advanced remarkably recent decades, more been approved, they already demonstrated their potential diseases, cancer. This review paper introduces current status advances therapy for treatment discusses tasks prospects ahead.

Язык: Английский

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Effect of neutrophils on tumor immunity and immunotherapy resistance with underlying mechanisms

Cancer Communications, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Neutrophils are key mediators of the immune response and play essential roles in development tumors evasion. Emerging studies indicate that neutrophils also a critical role immunotherapy resistance cancer. In this review, firstly, we summarize novel classification phenotypes describe regulatory relationships between tumor metabolism, flora microecology, neuroendocrine therapy from new perspective. Secondly, review mechanisms by which affect drug aspects microenvironment, antigens, epigenetics. Finally, propose several promising strategies for overcoming targeting provide research ideas area.

Язык: Английский

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Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways

Medical Oncology, Год журнала: 2023, Номер 40(11)

Опубликована: Окт. 19, 2023

Язык: Английский

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