Experimental Cell Research, Год журнала: 2024, Номер 442(2), С. 114278 - 114278
Опубликована: Окт. 1, 2024
Язык: Английский
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(9), С. 2236 - 2252
Опубликована: Янв. 1, 2024
Plant-derived exosomes (PDEs) show promising potential to be developed as a therapeutic agent against cancer, owing their multiple advantages such low toxicity, biocompatibility, availability, affordability, etc.
Язык: Английский
Процитировано
29
Drug Resistance Updates, Год журнала: 2024, Номер 73, С. 101058 - 101058
Опубликована: Янв. 19, 2024
Язык: Английский
Процитировано
22
The Journal of Liquid Biopsy, Год журнала: 2023, Номер 2, С. 100129 - 100129
Опубликована: Ноя. 26, 2023
Cancer is an unsolved health crisis worldwide. Extracellular vesicles (EVs) address this problem in a new way. In cancer, early detection highly challenging, exosomes (a subpopulation of EVs, originating from endosomes) overcome limitation. tumor-derived (TEXs) play role as signaling molecules cancer development and progression. TEXs required more detailed investigation for specific biomarkers research. Exosome heterogeneity (some the facts regulate it such exosome size, origin, inner molecular diversity) made complication liquid biopsy. Single profiling barcoding support overcoming limitation developing precision oncology. interdisciplinary approach screening specifically.
Язык: Английский
Процитировано
26
The Journal of Liquid Biopsy, Год журнала: 2024, Номер 3, С. 100138 - 100138
Опубликована: Янв. 4, 2024
Extracellular vesicles (EVs) are the cell's secreted component. It is majorly classified into microvesicles, apoptotic bodies, and exosomes. Exosomes play a significant role in cancer development progression. Its molecular signature (DNA, RNA, Proteins, lipids) has more priority profiling current decade. In prevention, most challenging part early detection. EVs-based screening develops promising platform. Multi-Omics exosomes profiling-based liquid biopsy support detection efficient way. This approach provides detailed expression data (it may be inner cargos or surface express molecules). article highlited multi-omic exosome theranostics applications cancer, technical challenges, improvisation for future improvement.
Язык: Английский
Процитировано
16
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(8), С. 8489 - 8506
Опубликована: Апрель 15, 2024
Cancer is the most challenging health complication worldwide. Scientific society has tried to decode its complications and developing a smart solution for mankind. Extracellular vesicles (EVs) are an emerging frontier in cancer research. EVs provide fresh insight into understanding of released from all active cells. classified some major classes, such as apoptotic bodies, microvesicles, exosomes. Exosomes among exciting tools current research they work cellular messengers (which reflects cell's healthy or pathological conditional status). In tumor microenvironment, regulate several complicated events uncontrolled cell growth, immune suppression, angiogenesis, extracellular matrix remodeling, metastasis, organ-specific drug therapeutic resistance, stem development. also source promising biomarkers involved both diagnosis prognosis performs role. Exosomes-based nanomedicine which application nanosize theranostics sensor orientation, supports overcoming management limitations, early therapeutics specific, effective, affordable. this review, we have highlighted integration exosomes nanotechnology cutting-edge approach precision oncology.
Язык: Английский
Процитировано
16
Life Sciences, Год журнала: 2024, Номер 354, С. 122985 - 122985
Опубликована: Авг. 14, 2024
Язык: Английский
Процитировано
12
Clinical and Translational Discovery, Год журнала: 2024, Номер 4(1)
Опубликована: Янв. 28, 2024
Abstract The epithelial–mesenchymal transition (EMT) represents a pivotal frontier in oncology, playing central role the metastatic cascade of cancer—a leading global health challenge. This comprehensive review delves into complexities EMT, process where cancer cells gain exceptional mobility, facilitating their invasion distant organs and establishment secondary malignancies. We thoroughly examine myriad factors influencing encompassing transcription factors, signalling pathways, metabolic alterations, microRNAs, long non‐coding RNAs, epigenetic changes, exosomal interactions intricate dynamics tumour microenvironment. Particularly, emphasises advanced stages crucial for development highly aggressive phenotypes. During this phase, penetrate vascular barrier exploit bloodstream to propagate life‐threatening metastases through mesenchymal–epithelial transition. also explore EMT's significant fostering dormancy, senescence, emergence stem formidable challenge therapeutic resistance. Our transcends mere inventory EMT‐inducing elements; it critically assesses current state EMT‐focused clinical trials, revealing both hurdles breakthroughs. Highlighting potential EMT research, we project its transformative impact on future therapy. exploration is aimed at paving way towards an era effectively managing relentless disease, positioning forefront innovative research strategies.
Язык: Английский
Процитировано
11
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(4), С. 2128 - 2139
Опубликована: Апрель 3, 2024
Cancer research has made significant progress in recent years, and extracellular vesicles (EVs) based cancer investigation reveals several facts about cancer. Exosomes are a subpopulation of EVs. In the present decade, exosomes is mostly highlighted for theranostic research. Tumor cell derived (TEXs) promote but there multiple sources that can be used as therapeutic agents (plant exosomes, stem cell-derived modified or synthetic exosomes). Stem cells regenerative medicine faces numerous challenges, such tumor development, cellular reprogramming etc., therefore addressing these complications becomes essential. serves an answer to problems offers better solution. Global indicates also play dual role system by either inhibiting promoting Modified which genetically engineered surface increase efficacy properties considered target above concerns. However, difficulties associated with include variations heterogenity, isolation protocols, large scale production, have managed effectively. this review, we explore biogenesis, exosome sources, drug delivery, clinical trial related challenges domain future orientation. This article may encourage researchers develop effective affordable
Язык: Английский
Процитировано
11
ACS Applied Bio Materials, Год журнала: 2023, Номер 7(1), С. 44 - 58
Опубликована: Дек. 18, 2023
Epithelial-mesenchymal transition (EMT) is a fundamental process driving cancer metastasis, transforming non-motile cells into motile population that migrates to distant organs and forms secondary tumors. In recent years, research has revealed strong connection between exosomes the EMT. Exosomes, subpopulation of extracellular vesicles, facilitate cellular communication dynamically regulate various aspects including immune cell suppression, matrix remodeling, metastasis initiation, EMT organ-specific metastasis. Tumor-derived (TEXs) their molecular cargo, comprising proteins, lipids, nucleic acids, carbohydrates, are essential components promote in cancer. TEXs miRNAs play crucial role reprogramming tumor microenvironment, while TEX surface integrins contribute Exosome-based offers deeper understanding about an effective theranostic platform development. Additionally, therapeutic sources paving way for innovative treatment this Review, we spotlight impact, aiming inspire researchers worldwide explore fascinating field more ways.
Язык: Английский
Процитировано
21
The Journal of Liquid Biopsy, Год журнала: 2024, Номер 3, С. 100139 - 100139
Опубликована: Янв. 5, 2024
Recent advances in cancer treatment emphasize the pivotal role of extracellular vesicles (EVs), especially exosomes (a subpopulation EVs, originating from endosomes). Exosomes are signaling molecules cellular system. Its molecular signature displays status cell (cell healthy or undergoing any clinical complication). frontiers upcoming theranostics era. This article highlighted exosome complex interlink, advantage exosome-base liquid biopsy, effectiveness exosome-based cell-free therapy compared to therapy, complications research, and its solution. Hope, this motivated researchers explore precision oncology
Язык: Английский
Процитировано
7