Pathology - Research and Practice, Год журнала: 2024, Номер 266, С. 155747 - 155747
Опубликована: Ноя. 28, 2024
Язык: Английский
Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 23, 2025
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
Extracellular vesicles (EVs) are critical mediators of intercellular communication, carrying bioactive cargo and displaying diverse surface components that reflect their cellular origins functions. The EV surface, composed proteins, lipids, glycocalyx elements, plays a pivotal role in targeting recipient cells, mediating biological interactions, enabling selective delivery. This review comprehensively examined the molecular architecture surfaces, linking biogenesis to functional diversity, highlights therapeutic diagnostic potential diseases such as cancer cardiovascular disorders. Additionally, we explore emerging applications EVs, including machine-learning-assisted analysis, chemical integration, cross-system combinations. also discusses some key challenges clinical translation EV-related technologies.
Язык: Английский
Процитировано
1
RSC Advances, Год журнала: 2024, Номер 14(42), С. 30807 - 30829
Опубликована: Янв. 1, 2024
Modified exosomes are a smart tool for the upcoming precision cancer therapeutic era.
Язык: Английский
Процитировано
7
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 249, С. 114500 - 114500
Опубликована: Янв. 6, 2025
Язык: Английский
Процитировано
0
Brain Research Bulletin, Год журнала: 2025, Номер 222, С. 111256 - 111256
Опубликована: Фев. 12, 2025
Multiple sclerosis (MS) is a chronic autoimmune illness characterized by inflammation and demyelination of the central nervous system (CNS). The effective delivery therapeutic agents to CNS continues be an important barrier in MS treatment due blood-brain limited access affected areas. Exosome-based drug systems have become attractive option for targeted therapy MS. Exosomes, small extracellular vesicles derived from various cell types, possess unique biological properties that make them ideal nanocarriers delivering cargo specific populations CNS. In this study, we supply comprehensive overview current advances future perspectives exosome-based We discuss biogenesis exosomes, strategies loading, engineering approaches enhance their targeting capabilities, potential clinical applications exosome-mediated therapy. Additionally, explore preclinical studies animal models demonstrate effectiveness ameliorating pathology. By highlighting challenges opportunities utilizing exosomes as vehicles, review aims contribute growing body knowledge field nanomedicine Considering accessibility, specificity, therapies while minimizing off-target effects might change scenario
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 12, 2025
As we progress into the 21st century, cancer stands as one of most dreaded diseases. With approximately in every four individuals facing a lifetime risk developing cancer, remains serious health challenges worldwide. Its multifaceted nature makes it an arduous and tricky problem to diagnose treat. Over years, researchers have explored plenty approaches avenues improve management. One notable strategy includes study extracellular vesicles (EVs) potential biomarkers therapeutics. Among these EVs, exosomes emerged particularly promising candidates due their unique characteristic properties functions. They are small membrane-bound secreted by cells carrying cargo biomolecules such proteins, nucleic acids, lipids. These play crucial roles intercellular communication, facilitating transfer biological information between cell-to-cell communication. Exosomes transport cargoes DNA, RNA, lipids involved cellular reprogramming promoting cancer. In this review, explore molecular composition exosomes, significance chemistry development, its theranostic application well research complications solutions.
Язык: Английский
Процитировано
0
Clinical and Translational Discovery, Год журнала: 2024, Номер 4(4)
Опубликована: Июль 21, 2024
Abstract Exosomes are signalling molecules related to cell‐to‐cell communication. Based on sources (plants, stem cells, and immune cells derived exosomes) it offers promising therapeutic activity against cancer. Plant‐derived exosomes (PDEs) natural extracellular vesicles (EVs) that potent provide organic precision nanomedicine cancer therapeutics including targeted drug delivery. PDEs gaining attention due their safety efficacy. There plenty of different in nature. This article explores various plants such as carrots, ginger, lemons, cabbages, blueberries, oranges, tomatoes, grapefruits, tea leaves, which with distinct properties, anti‐inflammatory, antioxidant, anticancer activities. exhibit significant potential Ongoing research clinical trials predict will become effective, affordable solutions for treatment.
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6489 - 6489
Опубликована: Июнь 12, 2024
Gap injuries to the peripheral nervous system result in pain and loss of function, without any particularly effective therapeutic options. Within this context, mesenchymal stem cell (MSC)-derived exosomes have emerged as a potential option. Thus, focus study was review currently available data on MSC-derived exosome-mounted scaffolds nerve regeneration order identify most promising exosome sources field regeneration. We conducted systematic following PRISMA 2020 guidelines. Exosome origins varied (adipose-derived MSCs, bone marrow gingival MSC, induced pluripotent cells purified product) similarly materials (Matrigel, alginate silicone, acellular graft [ANG], chitosan, chitin, hydrogel fibrin glue). The compound muscle action (CMAP), sciatic functional index (SFI), gastrocnemius wet weight histological analyses were used main outcome measures. Overall, showed better than alone. Functionally, both exosome-enriched chitin ANG significant improvement over time sciatica index, CMAP weight. best outcomes found scaffold with high increase axonal diameter cross-section area. Further studies are needed confirm efficacy
Язык: Английский
Процитировано
2
Sustainable Food Technology, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Fruit exosomes are the source of natural cancer therapeutic tools.
Язык: Английский
Процитировано
2
Clinical and Translational Discovery, Год журнала: 2024, Номер 4(3)
Опубликована: Июнь 1, 2024
Abstract Extracellular vesicles (EVs), including exosomes, ectosomes, and apoptotic bodies, play crucial roles in cellular communication disease processes. Among these, exosomes are particularly significant for diagnosing, cancer (which remains a leading cause of death worldwide). Exosomes offer cutting‐edge approaches nanomedicine, biomarkers investigation (diagnosis prognosis), therapeutic. found several body fluids (Blood, plasma, serum, urine, saliva, sweat, CSF, tear). It transforms the liquid biopsy method with more specificity. Exosome‐based sensor (electrochemical aptamer‐based) developers were effective sensitive scanning. Therapeutic prospect stem cell‐derived plant‐derived become promising. Due to its non‐toxicity (depending on source), non‐immunogenic, biocompatibility ability cross biological membranes. an exciting nano‐drug transporter Current time‐modified support development effective, efficient, cost‐effective nanomedicine against cancer. Advanced nanotechnology exosome combining (single profiling, barcoding)transform theranostics approaches. introduce new horizon nanomedicine.
Язык: Английский
Процитировано
0