Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Июнь 4, 2025

Nucleolar spindle-associated protein 1 (NUSAP1) is a microtubule-binding critical in the mitotic cell cycle. Its primary functions encompass maintaining microtubule stability, facilitating spindle assembly, regulating chromosome alignment, and modulating multiple signaling pathways. The incidence mortality rates of digestive system neoplasms are among highest all malignant tumors. Therefore, identifying effective biological targets for targeted cancer control treatment strategies critical. Recent studies have demonstrated that NUSAP1 highly expressed various tumors plays pivotal role initiation, progression, treatment, prognosis these by mitosis key distinctive function positions it as central molecule linking dysregulation with tumorigenesis, exhibiting dual potential both diagnostic marker therapeutic target. This article primarily reviews structural characteristics, functional mechanisms, related pathways NUSAP1, focusing on exploring mechanisms neoplasms. objective to offer new research perspectives into diagnosis, evaluation

Язык: Английский