Research progress on NUSAP1 and its role in digestive system neoplasms DOI Creative Commons
Siqing Fu, Yuting Zhuo, Tao Yu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: June 4, 2025

Nucleolar spindle-associated protein 1 (NUSAP1) is a microtubule-binding critical in the mitotic cell cycle. Its primary functions encompass maintaining microtubule stability, facilitating spindle assembly, regulating chromosome alignment, and modulating multiple signaling pathways. The incidence mortality rates of digestive system neoplasms are among highest all malignant tumors. Therefore, identifying effective biological targets for targeted cancer control treatment strategies critical. Recent studies have demonstrated that NUSAP1 highly expressed various tumors plays pivotal role initiation, progression, treatment, prognosis these by mitosis key distinctive function positions it as central molecule linking dysregulation with tumorigenesis, exhibiting dual potential both diagnostic marker therapeutic target. This article primarily reviews structural characteristics, functional mechanisms, related pathways NUSAP1, focusing on exploring mechanisms neoplasms. objective to offer new research perspectives into diagnosis, evaluation

Language: Английский

Recent advances in DNA nanotechnology for cancer detection and therapy: A review DOI

Donya Esmaeilpour,

Matineh Ghomi, Ehsan Nazarzadeh Zare‬

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142136 - 142136

Published: March 1, 2025

Language: Английский

Citations

0
Molecular mechanisms and clinical significance of perineural invasion in malignancies: the pivotal role of tumor-associated Schwann cells in cancer progression and metastasis DOI

Noura A. A. Ebrahim,

Soliman M. A. Soliman,

Maha Othman

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: April 21, 2025

Language: Английский

Citations

0
Stimuli-responsive smart nanomaterials for theranostics of urological cancers DOI

Yi Xu,

Madineh Moradialvand, Francesca Della Sala

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 539, P. 216745 - 216745

Published: May 1, 2025

Language: Английский

Citations

0
Functional Nanoparticle Developments for 3D-Printed Biodegradable Implants- A Comprehensive Review DOI Creative Commons
Mohammad Jakir Hossain, Md Istiaq Mohhamad Shuvo, Safiullah Khan

et al.

Results in Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: 19, P. 100541 - 100541

Published: May 1, 2025

Language: Английский

Citations

0
Research progress on NUSAP1 and its role in digestive system neoplasms DOI Creative Commons
Siqing Fu, Yuting Zhuo, Tao Yu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: June 4, 2025

Nucleolar spindle-associated protein 1 (NUSAP1) is a microtubule-binding critical in the mitotic cell cycle. Its primary functions encompass maintaining microtubule stability, facilitating spindle assembly, regulating chromosome alignment, and modulating multiple signaling pathways. The incidence mortality rates of digestive system neoplasms are among highest all malignant tumors. Therefore, identifying effective biological targets for targeted cancer control treatment strategies critical. Recent studies have demonstrated that NUSAP1 highly expressed various tumors plays pivotal role initiation, progression, treatment, prognosis these by mitosis key distinctive function positions it as central molecule linking dysregulation with tumorigenesis, exhibiting dual potential both diagnostic marker therapeutic target. This article primarily reviews structural characteristics, functional mechanisms, related pathways NUSAP1, focusing on exploring mechanisms neoplasms. objective to offer new research perspectives into diagnosis, evaluation

Language: Английский

Citations

0