Recent Development of Fluoroquinolone Derivatives as Anticancer Agents

Molecules, Год журнала: 2024, Номер 29(15), С. 3538 - 3538

Опубликована: Июль 27, 2024

Cancer is the second leading cause of death in world following cardiovascular disease. Its treatment, including radiation therapy and surgical removal tumour, based on pharmacotherapy, which prompts a constant search for new more effective drugs. There are high costs associated with designing, synthesising, marketing substances. Drug repositioning an attractive solution. Fluoroquinolones make up group synthetic antibiotics broad spectrum activity bacterial diseases. Moreover, those compounds particular interest to researchers as result reports their antiproliferative effects cells most lethal cancers. This article presents current progress development fluoroquinolone derivatives potential anticancer cytotoxic activity, well structure-activity relationships, along possible directions further development.

Язык: Английский

Unraveling the Curcumin's Molecular Targets and Its Potential in Suppressing Skin Inflammation Using Network Pharmacology and In Vitro Studies

Drug Development Research, Год журнала: 2025, Номер 86(1)

Опубликована: Фев. 1, 2025

ABSTRACT Curcumin, a polyphenol compound derived from turmeric, has garnered attention for its anti‐inflammatory and antioxidant properties, making it promising candidate treating skin inflammation. Despite potential, the underlying pharmacological effects to inflammation remain unclear. Therefore, this study aimed reveal curcumin's molecular targets potential in suppressing using network pharmacology vitro experiments. A total of 7,393 239 related curcumin inflammation, respectively, were obtained public databases. By drawing Venn diagram, 216 common identified as targets. These subjected gene function pathway enrichment analyses, protein‐protein interaction was established investigate impact on The functions mainly associated with inflammatory response, membrane raft, serine‐type endopeptidase activity. NF‐κB MAPK pathways could be major through which acts Ten treatment identified: AKT1, TNF, EGFR, APP, MMP9, STAT3, HIF1A, PTGS2, EP300, GSK3B. Molecular docking analysis results showed high binding affinity GSK3B, may contribute inhibitory effect In experiments confirmed by reducing expression levels NO, IL‐1β, IL‐6 LPS‐induced HaCaT cells. Taken together, reveals paving way invivo clinical investigations.

Язык: Английский

Network Pharmacology Combined with Bioinformatics Analysis to Texplore the Potential Mechanism of Phellodendri Chinensis Cortex Against Bladder Cancer

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер 82(4), С. 3317 - 3331

Опубликована: Июль 18, 2024

Язык: Английский