Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 7, 2025

Exosomes are small extracellular vesicles of endocytic origin released by various cell types. They consist lipid bilayers containing macromolecules such as lipids, proteins, microRNAs, growth factors, cytokines, and carbohydrates. play a critical role in the diagnosis treatment diseases. For instance, exosome contents have been utilized biomarkers body fluids (urine, saliva, serum) to identify cancers, autoimmune diseases, inflammatory conditions sepsis. Due their size ability reach tumor microenvironments, exosomes also used carriers for chemotherapeutic drugs drug delivery systems. Furthermore, evidence indicates that malignant cells release into microenvironment, influencing immune paracrine manner. Additionally, cell-derived exosomes, those from Natural Killer (NK) or cytotoxic T lymphocytes (CTLs), show potential therapeutic agents treating malignancies like leukemia. This review discusses diagnostic hematological explores these

Язык: Английский

Exosomes and their roles in major depressive disorder: an overview of the research progress and perspectives

Deleted Journal, Год журнала: 2025, Номер unknown, С. 100035 - 100035

Опубликована: Март 1, 2025

Язык: Английский