Lipid metabolism, remodelling and intercellular transfer in the CNS
Nature reviews. Neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Язык: Английский
Effect of Dietary Phospholipid on the Behavior in C57BL/6J Mice
Journal of Evolutionary Biochemistry and Physiology,
Год журнала:
2024,
Номер
60(1), С. 409 - 419
Опубликована: Янв. 1, 2024
Язык: Английский
Low-Dose Radiation Induces Alterations in Fatty Acid and Tyrosine Metabolism in the Mouse Hippocampus: Insights from Integrated Multiomics
Rekha Koravadi Narasimhamurthy,
Babu Santhi Venkidesh,
Sampara Vasishta
и другие.
ACS Chemical Neuroscience,
Год журнала:
2024,
Номер
15(18), С. 3311 - 3320
Опубликована: Авг. 26, 2024
In
recent
years,
there
has
been
a
drastic
surge
in
neurological
disorders
with
sporadic
cases
contributing
more
than
ever
to
their
cause.
Radiation
exposure
through
diagnostic
or
therapeutic
routes
often
results
injuries
that
may
lead
neurodegenerative
pathogenesis.
However,
the
underlying
mechanisms
regulating
impact
of
near-low
doses
ionizing
radiation
are
not
known.
particular,
changes
caused
by
metabolomic
reprogramming
have
yet
elucidated.
Hence,
present
study,
C57BL/6
mice
were
exposed
single
whole-body
X-ray
dose
0.5
Gy,
and
14
days
post-treatment,
hippocampus
was
subjected
analysis.
The
irradiated
animals
showed
significant
alterations
15
metabolites,
which
aligned
altered
tyrosine,
phenylalanine,
alpha-linolenic
acid
metabolism
biosynthesis
unsaturated
fatty
acids.
Furthermore,
multiomics
interaction
network
comprising
metabolomics
RNA
sequencing
data
analysis
provided
insights
into
gene-metabolite
interactions.
Tyrosine
revealed
be
most
altered,
demonstrated
several
crucial
genes
metabolites.
study
regulation
low-dose
radiation-induced
neurotoxicity
at
level
its
implications
for
pathogenesis
disorders.
also
provides
novel
pathways
following
near-low-dose
IR
link
diseases
such
as
Alzheimer's
disease
Parkinson's
disease.
Язык: Английский
Phospholipid supplementation inhibits male and female odor discrimination in mice
Frontiers in Behavioral Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Июль 25, 2024
Dietary
phospholipids
(PLs)
are
promising
supplements
that
commonly
found
as
natural
food
ingredients
and
emulsifier
additives.
The
present
study
aimed
to
evaluate
the
effect
of
major
PLs
in
on
social
behavior
mice.
In
this
study,
short-term
high
dietary
PL
content
was
studied
terms
odor
discrimination
interactions
with
male
female
intruders
We
used
habituation
tests
demonstrate
PL-fed
mice
tend
lose
preference
toward
fail
discriminate
against
socially
significant
scents.
At
same
time,
test
animals
recognize
non-social
odors.
also
affected
males,
who
behave
indiscriminately
during
direct
contact.
Brain
metabolomic
profiling
revealed
no
changes
intermediary
metabolism
or
neurotransmitter
biosynthesis.
intranasal
application
resembled
effects
supplementation.
These
data
suggest
certain
might
suppress
pheromone
perception
olfactory
system
affect
sense
important
cues.
Язык: Английский
Effect of dietary phospholipid on the behavior in C57BL/6J mice
Российский физиологический журнал им И М Сеченова,
Год журнала:
2024,
Номер
110(2), С. 254 - 267
Опубликована: Авг. 2, 2024
Nowadays
phospholipids
are
widely
used
as
hepatoprotective,
neuroprotective
and
anti-stress
drugs,
well
the
dietary
supplements.
Besides,
lecithin
consisting
up
to
70%
of
mixture:
phosphatidylcholine,
phosphatidylethanolamine,
phosphatidylinositol
phosphatidic
acid,
is
often
component
food
production
an
emulsifier.
Dose
these
biologically
active
substances
in
modern
human
diet
could
be
quite
high.
Previously
we
have
shown
that
chronic
intestinal
inflammation
Muc2-knockout
mice
induces
behavioral
changes
along
with
significant
increase
content
epithelial
cells,
particularly,
phosphatidylserine
acid.
Here
investigate
effects
long-term
administration
a
mixture
phospholipids,
soy
on
patterns
laboratory
mice.
Animals
taken
phospholipid
shows
no
normally
observed
preference
towards
females
two
intruders
test
(with
female
male).
In
social
odor
test,
they
also
did
not
distinguish
male
odors,
while
non-social
odors
discrimination
preserved.
addition,
identified
decrease
anxiety,
obsessive
traits,
schizophrenia-like
behavior
traits
animals.
Soy
supplementation
had
similar
compulsive
increased
aggression
males.
Thus,
perinatal
either
(phosphatidylcholine,
acid)
or
can
influence
various
aspects
Язык: Английский