Exploring the Role of Apigenin in Neuroinflammation: Insights and Implications
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(9), С. 5041 - 5041
Опубликована: Май 6, 2024
Neuroinflammation,
a
hallmark
of
various
central
nervous
system
disorders,
is
often
associated
with
oxidative
stress
and
neuronal
or
oligodendrocyte
cell
death.
It
therefore
very
interesting
to
target
neuroinflammation
pharmacologically.
One
therapeutic
option
the
use
nutraceuticals,
particularly
apigenin.
Apigenin
present
in
plants:
vegetables
(parsley,
celery,
onions),
fruits
(oranges),
herbs
(chamomile,
thyme,
oregano,
basil),
some
beverages
(tea,
beer,
wine).
This
review
explores
potential
apigenin
as
an
anti-inflammatory
agent
across
diverse
neurological
conditions
(multiple
sclerosis,
Parkinson's
disease,
Alzheimer's
disease),
cancer,
cardiovascular
diseases,
cognitive
memory
toxicity
related
trace
metals
other
chemicals.
Drawing
upon
major
studies,
we
summarize
apigenin's
multifaceted
effects
underlying
mechanisms
neuroinflammation.
Our
underscores
promise
calls
for
further
investigation
into
its
clinical
applications.
Язык: Английский
Neuroprotective effects of Shenghui decoction via inhibition of the JNK/p38 MAPK signaling pathway in an AlCl3-induced zebrafish (Danio rerio) model of Alzheimer's disease
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
328, С. 117993 - 117993
Опубликована: Фев. 27, 2024
Язык: Английский
Daidzein ameliorates nonmotor symptoms of manganese‐induced Parkinsonism in zebrafish model: Behavioural and biochemical approach
British Journal of Pharmacology,
Год журнала:
2024,
Номер
181(16), С. 2947 - 2963
Опубликована: Апрель 28, 2024
Abstract
Background
and
Purpose
Parkinson's
disease
(PD)
is
a
prevalent
neurodegenerative
movement
disorder
characterized
by
motor
dysfunction.
Environmental
factors,
especially
manganese
(Mn),
contribute
significantly
to
PD.
Existing
therapies
are
focused
on
coordination,
whereas
nonmotor
features
such
as
neuropsychiatric
symptoms
often
neglected.
Daidzein
(DZ),
phytoestrogen,
has
piqued
interest
due
its
antioxidant,
anti‐inflammatory,
anxiolytic
properties.
Therefore,
we
anticipate
that
DZ
might
be
an
effective
drug
alleviate
the
of
Mn‐induced
Parkinsonism.
Experimental
Approach
Naïve
zebrafish
were
exposed
2
mM
Mn
for
21
days
intervened
with
DZ.
Nonmotor
anxiety,
social
behaviour,
olfactory
function
assessed.
Acetylcholinesterase
(AChE)
activity
antioxidant
enzyme
status
measured
from
brain
tissue
through
biochemical
assays.
Dopamine
levels
histology
performed
elucidate
neuroprotective
mechanism
Key
Results
exhibited
effects
in
novel
environment
also
improved
intra
inter
fish
behaviour.
response
amino
acid
stimuli
reduced
oxidative
stress
AChE
prevented
neuronal
damage.
increased
DA
level
brain,
collectively
contributing
neuroprotection.
Conclusion
Implications
demonstrated
promising
effect
alleviating
anxiety
dysfunction,
mitigation
cellular
These
findings
underscore
therapeutic
potential
addressing
neurotoxicity
induced
heavy
metals,
particularly
context
Язык: Английский
Protective Effect of Sulfur-Containing Heterocyclic Analogs Against Acrylamide-Induced Behavioral and Biochemical Alterations in Zebrafish
Molecular Neurobiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 20, 2024
Язык: Английский
Ferroptosis involvement in the neurotoxicity of flunitrazepam in zebrafish
Aquatic Toxicology,
Год журнала:
2024,
Номер
unknown, С. 107128 - 107128
Опубликована: Окт. 1, 2024
Язык: Английский
Mechanisms by which Ganglioside GM1, a specific type of glycosphingolipid, ameliorates BMAA-induced neurotoxicity in early-life stage of zebrafish embryos
Food Research International,
Год журнала:
2024,
Номер
200, С. 115502 - 115502
Опубликована: Дек. 9, 2024
Язык: Английский
The Beneficial Effects of Combined Exercise and Polyphenols in Alzheimer's Disease
Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
Regular
exercise
enhances
life
quality,
lowers
the
risk
of
cognitive
damage,
and
slows
advancement
Alzheimer's
disease
(AD).
Natural
compounds
rich
in
polyphenols
have
garnered
attention
as
a
non-pharmacological
means
treating
preventing
AD.
The
primary
component
wine,
grape
seeds,
nuts
is
polyphenols.
Research
suggests
that
slow
down
rate
neurodegeneration
AD
lessen
learning
impairment.
Furthermore,
brain
impairments
related
to
cognition.
Additionally,
can
specifically
restructure
amyloid-β
(Aβ)
structures
soluble
oligomers
into
non-toxic
alternative
species.
They
also
been
revealed
increase
brain-derived
neurotrophic
factors
expression,
suggesting
they
positive
impact
on
creation
neurotrophins.
benefits
polyphenol
supplementation
exercise,
which
both
provide
neuroprotection,
not
well
studied
patients.
This
review
aimed
investigate
effects
combined
inflammation,
several
conformational
toxic
species
Aβ,
Aβ-induced
apoptosis
Язык: Английский