Co-administration of coenzyme Q10 and curcumin mitigates cognitive deficits and exerts neuroprotective effects in aluminum chloride-induced Alzheimer's disease in aged mice DOI Creative Commons

N.M. Al Rasheed,

Hafiza Khushbakht Hussain,

Zohabia Rehman

и другие.

Experimental Gerontology, Год журнала: 2024, Номер 199, С. 112659 - 112659

Опубликована: Дек. 19, 2024

Aluminum chloride (AlCl3), a known neurotoxic and Alzheimerogenic metal disrupts redox homeostasis which plays pivotal role in pathophysiology of neurodegenerative disorders, particularly cognitive decline. The current study was designed to unveil the long-term neuroprotective outcomes efficacy CoQ10 curcumin low dose (100 mg/kg each) combination 18-months old geriatric male Balb/c mice subjected AlCl3-prompted memory derangements (200 water bottles) for 28 days. properties driven by antioxidant mechanisms were assessed via observing cellular pathology key-memory related brain regions including cornuammonis (CA3 DG) cortex 2/3 layer. Our revealed that AlCl3 exposure significantly reduced spatial learning memory. In contrast, combinatorial regime markedly mitigated deficits Vs. individual high-dose AlCl3-treated animals as demonstrated their improved performance neurobehavioral tests such Y-maze, novel object recognition, passive avoidance Morris-water maze test. Additionally, co-administration restored balance reducing levels oxidative stressor (MDA) increasing anti-oxidant capacity (SOD,GPx). AchE is an enzyme involved acetylcholine breakdown negatively impacts function. elevated brains vs. treatment. This neurochemical alteration notably reversed dual-treatment group. Furthermore, ameliorated AlCl3-induced neurotoxicity preserving neuronal cytoarchitecture both cortical hippocampal regions. conclusion, might attenuate loss induced AlCl3-intoxication restoring aberrant activity, enhanced defenses salvaging deleterious damage.

Язык: Английский

Enhancement of Cognitive Benefits and Anti-Anxiety Effects of Phytolacca americana Fruits in a Zebrafish (Danio rerio) Model of Scopolamine-Induced Memory Impairment DOI Creative Commons

Lucia‐Florina Popovici,

Ion Brinza, Florentina Gatea

и другие.

Antioxidants, Год журнала: 2025, Номер 14(1), С. 97 - 97

Опубликована: Янв. 15, 2025

Phytolacca americana fruits exhibit a wide range of biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. This study aims to investigate the phenolic profile hydroethanolic extracts from both fresh (PEC) dried (PEU) P. using high-performance liquid chromatography (HPLC) evaluate their impact on anxiety-like behavior, memory, oxidative stress, cholinergic status in zebrafish (Danio rerio, Tübingen strain) treated with scopolamine (SCO, 100 μM). Acute administration PEC PEU (0.1, 0.5, 1 mg/L) was conducted for one hour per day. In silico analyses were performed pharmacokinetic characteristics compounds discerned two extracts, platforms such as SwissAdme, Molinspiration, ProToX-III, AdmetLab 3.0, PKCSM, PASS. Anxiety-like behavior memory performance assessed through specific behavioral assays, novel tank test (NTT), light/dark (LD), approach (NAT), Y-maze, object recognition (NOR). Subsequently, activity acetylcholinesterase (AChE) extent stress brain investigated. Our findings suggest that possess anxiolytic effects, alleviating SCO-induced anxiety enhancing cognitive amnesic zebrafish. Furthermore, these demonstrated ability mitigate deficits by inhibiting AChE supporting antioxidant defense mechanisms increased enzymes reduced lipid protein peroxidation. These results highlight potential use fruit managing impairments related dementia conditions.

Язык: Английский

Процитировано

1
Shenghui Decoction inhibits neuronal cell apoptosis to improve Alzheimer's disease through the PDE4B/cAMP/CREB signaling pathway DOI

Gai Gao,

Xiaowei Zhang,

Zheng-hao Cui

и другие.

Phytomedicine, Год журнала: 2025, Номер 137, С. 156366 - 156366

Опубликована: Янв. 2, 2025

Язык: Английский

Процитировано

0
Ginsenosides Rg1, Rb1 and rare ginsenosides: promising candidate agents for Parkinson's disease and Alzheimer's disease and network pharmacology analysis DOI Creative Commons

Mingchun Jiang,

Jiaxin Chi,

Yifan Qiao

и другие.

Pharmacological Research, Год журнала: 2025, Номер 212, С. 107578 - 107578

Опубликована: Янв. 5, 2025

Ginseng has been commonly used as a traditional Chinese medicine in Asian countries for thousands of years. Ginsenosides are the main pharmacologically active ingredients isolated from ginseng and have neuroprotective effects treatment neurodegenerative disorders, such Parkinson's disease (PD) Alzheimer's (AD). To summarise investigate protective roles ginsenosides their underlying mechanisms PD AD, we ''Ginsenoside", ''Parkinson's disease", ''Alzheimer's ''anti-inflammatory", ''antioxidant", ''apoptosis" keywords to search extract relevant literature information scientific databases Elsevier, PubMed, Google Scholar databases. In particular, network pharmacology identify potential targets Rg1 Rb1 AD. By analysing existing research advances results, found that ginsenosides, primarily mediated through anti-inflammation, anti-apoptosis anti-oxidative stress, etc, may be associated with PI3K/Akt, BDNF/TrkB, MAPKs, NF-κB, Nrf2 Wnt/β-catenin signalling pathways. This review systematically summarises different Rg1, Rb1, rare AD provides new strategies disorders. Network paradigm using Rb1.

Язык: Английский

Процитировано

0
Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis DOI Creative Commons
Jiaxuan He,

Peiye Xu,

Ting Xu

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 16

Опубликована: Янв. 7, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder, with amyloid-beta (Aβ) aggregation playing key role in its pathogenesis. Aβ-induced oxidative stress leads to neuronal damage, mitochondrial dysfunction, and apoptosis, making antioxidative strategies promising for AD treatment. This study investigates the effects of hydrogen-rich water (HRW) zebrafish model. Zebrafish were exposed aluminum chloride induce AD-like pathology then treated HRW using nanobubble device. Behavioral assays, ELISA, Hematoxylin-eosin (H&E) staining, reactive oxygen species (ROS) neutrophil fluorescence labeling employed assess HRW's impact. Additionally, 16S rRNA sequencing analyzed effect on gut microbiota. can significantly improve cognitive impairment depression-like behavior model, reduce Aβ deposition (p < 0.0001), regulate liver Soluble epoxide hydrolase (sEH) levels 0.05), neuroinflammation, stress. Furthermore, reduced number harmful bacteria linked by restoring balance microbiota gut. These findings suggest that has potential as therapeutic strategy targeting stress, inflammation, gut-brain axis modulation.

Язык: Английский

Процитировано

0
Toll-Like Receptor 4-Mediated Neuroinflammation: Updates on Pathological Roles and Therapeutic Strategies in Chronic Cerebral Hypoperfusion DOI

Nuttapong Yawoot,

Jiraporn Tocharus, Chainarong Tocharus

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Язык: Английский

Процитировано

0
Novel Insights into the Efficacy, Optimal Active Constituents, And Pharmacological Mechanisms of Arisaema Heterophyllum Blume Against Alzheimer's Disease Through Multi-Model and Phytochemical Analysis DOI
Ruidie Shi, Yuqing Li,

Lei Mou

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Co-administration of coenzyme Q10 and curcumin mitigates cognitive deficits and exerts neuroprotective effects in aluminum chloride-induced Alzheimer's disease in aged mice DOI Creative Commons

N.M. Al Rasheed,

Hafiza Khushbakht Hussain,

Zohabia Rehman

и другие.

Experimental Gerontology, Год журнала: 2024, Номер 199, С. 112659 - 112659

Опубликована: Дек. 19, 2024

Aluminum chloride (AlCl3), a known neurotoxic and Alzheimerogenic metal disrupts redox homeostasis which plays pivotal role in pathophysiology of neurodegenerative disorders, particularly cognitive decline. The current study was designed to unveil the long-term neuroprotective outcomes efficacy CoQ10 curcumin low dose (100 mg/kg each) combination 18-months old geriatric male Balb/c mice subjected AlCl3-prompted memory derangements (200 water bottles) for 28 days. properties driven by antioxidant mechanisms were assessed via observing cellular pathology key-memory related brain regions including cornuammonis (CA3 DG) cortex 2/3 layer. Our revealed that AlCl3 exposure significantly reduced spatial learning memory. In contrast, combinatorial regime markedly mitigated deficits Vs. individual high-dose AlCl3-treated animals as demonstrated their improved performance neurobehavioral tests such Y-maze, novel object recognition, passive avoidance Morris-water maze test. Additionally, co-administration restored balance reducing levels oxidative stressor (MDA) increasing anti-oxidant capacity (SOD,GPx). AchE is an enzyme involved acetylcholine breakdown negatively impacts function. elevated brains vs. treatment. This neurochemical alteration notably reversed dual-treatment group. Furthermore, ameliorated AlCl3-induced neurotoxicity preserving neuronal cytoarchitecture both cortical hippocampal regions. conclusion, might attenuate loss induced AlCl3-intoxication restoring aberrant activity, enhanced defenses salvaging deleterious damage.

Язык: Английский

Процитировано

0