A review of the pathogenesis of epilepsy based on the microbiota-gut-brain-axis theory DOI Creative Commons

Wentao Yang,

Hua Cui,

Chaojie Wang

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Окт. 3, 2024

The pathogenesis of epilepsy is related to the microbiota-gut-brain axis, but mechanism has not been clarified. axis divided into (upward pathways) and brain-gut-microbiota (downward according direction conduction. Gut microorganisms are involved in pathological physiological processes human body participate epileptogenesis through neurological, immunological, endocrine, metabolic pathways, as well gut barrier blood brain mediated upward pathways. After epilepsy, downward pathway by HPA autonomic nerves triggers "leaky "and gut," resulting formation microbial structures enterobacterial metabolites associated with epileptogenicity, re-initiating seizures via pathway. Characteristic changes pathways epileptic patients provide new targets for clinical prevention treatment Based on these changes, this review further redescribes provides a its treatment.

Язык: Английский

Gut Microbiota-Bile Acid Metabolic Disorder Involved in the Cognitive Impairments in Epilepsy through HO-1 Dependent Ferroptosis DOI Creative Commons
Xinyu Li,

Jia Ji,

Jing Li

и другие.

Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101291 - 101291

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Lipid metabolism: Novel approaches for managing idiopathic epilepsy DOI
Chao Wang, Jinxia Zhai,

Xuemei Zhou

и другие.

Neuropeptides, Год журнала: 2024, Номер 108, С. 102475 - 102475

Опубликована: Сен. 30, 2024

Язык: Английский

Процитировано

1
The role of gut microbiota and metabolomic pathways in modulating the efficacy of SSRIs for major depressive disorder DOI Creative Commons
Ying Jiang,

Yucai Qu,

Lingyi Shi

и другие.

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 18, 2024

Язык: Английский

Процитировано

1
Potential causal link between dietary intake and epilepsy: a bidirectional and multivariable Mendelian randomization study DOI Creative Commons

Shenglong Lai,

Yazhou Xing,

Haiyang Li

и другие.

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Авг. 30, 2024

Epilepsy is a common neurological disease, and dietary intake has been suggested as potential modifiable risk factor. However, the causality of associations between epilepsy remains uncertain. This study aimed to investigate causal relationships various intakes using Mendelian randomization (MR) analysis.

Язык: Английский

Процитировано

0
A review of the pathogenesis of epilepsy based on the microbiota-gut-brain-axis theory DOI Creative Commons

Wentao Yang,

Hua Cui,

Chaojie Wang

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Окт. 3, 2024

The pathogenesis of epilepsy is related to the microbiota-gut-brain axis, but mechanism has not been clarified. axis divided into (upward pathways) and brain-gut-microbiota (downward according direction conduction. Gut microorganisms are involved in pathological physiological processes human body participate epileptogenesis through neurological, immunological, endocrine, metabolic pathways, as well gut barrier blood brain mediated upward pathways. After epilepsy, downward pathway by HPA autonomic nerves triggers "leaky "and gut," resulting formation microbial structures enterobacterial metabolites associated with epileptogenicity, re-initiating seizures via pathway. Characteristic changes pathways epileptic patients provide new targets for clinical prevention treatment Based on these changes, this review further redescribes provides a its treatment.

Язык: Английский

Процитировано

0