High-fat diet and neuroinflammation: the role of mitochondria

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107615 - 107615

Опубликована: Янв. 1, 2025

Язык: Английский

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Altered cognitive function in obese patients: relationship to gut flora

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Язык: Английский

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Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice

Frontiers in Neuroscience, Год журнала: 2025, Номер 18

Опубликована: Янв. 8, 2025

In recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation impaired performance. The aim this study was to investigate potential effects Morinda officinalis oligosaccharides (MOO) on its symptom, dysfunction. Chronic unpredictable mild stress (CUMS)-induced model constructed, MOO abilities were evaluated. results revealed that able alleviate CUMS-induced depression-like behavior in mice, inhibit hippocampal neuron apoptosis, reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels hippocampus, modulate composition distribution gut microbiota, abundance probiotics after continuous gavage for 28 days. further confirmed dysfunction is closely related development by improving lack low performance depressed modulating disruption sex hormone secretion serum, alleviating sperm morphology functional defects epididymis. These findings provide basis exploring antidepressant mechanism, use improve hypogonadotropic symptoms, future new drug improves symptoms.

Язык: Английский

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Diosmetin Delays In Vitro Aging of Porcine Oocytes by Improving Mitochondrial Function and Reducing Oxidative Stress

Animals, Год журнала: 2025, Номер 15(3), С. 291 - 291

Опубликована: Янв. 21, 2025

Oocyte quality is crucial for successful fertilization and subsequent embryonic development. Post-ovulatory aging leads to reduced oocyte impaired embryogenesis, representing an unavoidable challenge in terms of certain assisted reproductive techniques. Diosmetin (DIOS), a natural flavonoid found lemons, spearmint, spider moss, exhibits antioxidant, anti-inflammatory, anti-apoptotic properties. However, its effects on the mature porcine oocytes vitro remain unexplored. This study investigated impact DIOS aging. In IVM medium, fresh were cultured 44 h, while 68 h. Following addition varying concentrations (0.01, 0.1, 1 μM) DIOS-treated group was The results demonstrated that 0.1 μM significantly improved blastocyst rates cell counts, reactive oxygen species (ROS), elevated glutathione (GSH) levels, enhanced mitochondrial function, decreased markers autophagy (LC3B), apoptosis (annexin V), endoplasmic reticulum stress (CHOP), senescence (SA-β-Gal). Furthermore, treatment upregulated expression relevant genes compared aged group. These findings suggest effectively delays

Язык: Английский

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Diosmetin Attenuates Painful Symptoms Caused by Antineoplastics Paclitaxel and Anastrozole in Mice

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Язык: Английский

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