Diosmetin Attenuates Painful Symptoms Caused by Antineoplastics Paclitaxel and Anastrozole in Mice DOI
Samuel Felipe Atuati, Gabriela Becker, Sara Marchesan Oliveira

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

High-fat diet and neuroinflammation: the role of mitochondria DOI Creative Commons

Mingxue Song,

Yao Bai, Fuyong Song

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107615 - 107615

Published: Jan. 1, 2025

Language: Английский

Citations

3
Altered cognitive function in obese patients: relationship to gut flora DOI Creative Commons

Mengyuan Deng,

Fushan Tang, Zhaoqiong Zhu

et al.

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

Citations

2
Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice DOI Creative Commons

Mengjie He,

Mengying Hu,

Tingqiao Wang

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 8, 2025

In recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation impaired performance. The aim this study was to investigate potential effects Morinda officinalis oligosaccharides (MOO) on its symptom, dysfunction. Chronic unpredictable mild stress (CUMS)-induced model constructed, MOO abilities were evaluated. results revealed that able alleviate CUMS-induced depression-like behavior in mice, inhibit hippocampal neuron apoptosis, reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels hippocampus, modulate composition distribution gut microbiota, abundance probiotics after continuous gavage for 28 days. further confirmed dysfunction is closely related development by improving lack low performance depressed modulating disruption sex hormone secretion serum, alleviating sperm morphology functional defects epididymis. These findings provide basis exploring antidepressant mechanism, use improve hypogonadotropic symptoms, future new drug improves symptoms.

Language: Английский

Citations

0
Diosmetin Delays In Vitro Aging of Porcine Oocytes by Improving Mitochondrial Function and Reducing Oxidative Stress DOI Creative Commons
Jiajun Ren,

Xiu‐Wen Yuan,

Yuhao Zhang

et al.

Animals, Journal Year: 2025, Volume and Issue: 15(3), P. 291 - 291

Published: Jan. 21, 2025

Oocyte quality is crucial for successful fertilization and subsequent embryonic development. Post-ovulatory aging leads to reduced oocyte impaired embryogenesis, representing an unavoidable challenge in terms of certain assisted reproductive techniques. Diosmetin (DIOS), a natural flavonoid found lemons, spearmint, spider moss, exhibits antioxidant, anti-inflammatory, anti-apoptotic properties. However, its effects on the mature porcine oocytes vitro remain unexplored. This study investigated impact DIOS aging. In IVM medium, fresh were cultured 44 h, while 68 h. Following addition varying concentrations (0.01, 0.1, 1 μM) DIOS-treated group was The results demonstrated that 0.1 μM significantly improved blastocyst rates cell counts, reactive oxygen species (ROS), elevated glutathione (GSH) levels, enhanced mitochondrial function, decreased markers autophagy (LC3B), apoptosis (annexin V), endoplasmic reticulum stress (CHOP), senescence (SA-β-Gal). Furthermore, treatment upregulated expression relevant genes compared aged group. These findings suggest effectively delays

Language: Английский

Citations

0
Diosmetin Attenuates Painful Symptoms Caused by Antineoplastics Paclitaxel and Anastrozole in Mice DOI
Samuel Felipe Atuati, Gabriela Becker, Sara Marchesan Oliveira

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

Citations

0