Alterations in Zinc, Copper, and Iron Levels in the Retina and Brain of Alzheimer's Disease Patients and the APP/PS1 Mouse Model DOI Creative Commons
S. Mostafa Hosseinpour-Mashkani, David Bishop, Mika T. Westerhausen

и другие.

Metallomics, Год журнала: 2024, Номер 16(12)

Опубликована: Ноя. 8, 2024

Abstract Transition metals like copper (Cu), iron (Fe), and zinc (Zn) are vital for normal central nervous system function also linked to neurodegeneration, particularly in the onset progression of Alzheimer's disease (AD). Their alterations AD, identified prior amyloid plaque aggregation, offer a unique target staging pre-amyloid AD. However, analysing their levels brain is extremely challenging, necessitating development alternative approaches. Here, we utilized laser ablation–inductively coupled plasma–mass spectrometry solution nebulization–inductively quantitatively measure Cu, Fe, Zn concentrations retina hippocampus samples obtained from human donors (i.e. AD healthy controls), precursor protein/presenilin 1 (APP/PS1) mouse model wild-type (WT) controls, aged 9 18 months. Our findings revealed significantly elevated (*P < .05, P .01, .001) *P .05) compared controls. Conversely, APP/PS1 models exhibited notably lower metal same regions WT mice—Cu, (**P **P .05). The contrasting profiles samples, yet similar patterns within each species’ brain, suggest mirrors cerebral dyshomoeostasis lay groundwork pre-AD pathophysiology through assessment transition retina.

Язык: Английский

Multi‐Targeting Phytochemicals for Alzheimer's Disease DOI Open Access

R. Bhattacharya,

Raghuraj Singh,

Archna Panghal

и другие.

Phytotherapy Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Alzheimer's disease (AD) is a type of neurodegenerative illness in which β-amyloid (Aβ) and tau protein accumulate neurons the form tangles. The pathophysiological pathway AD consists Aβ-amyloid peptides, proteins, oxidative stress increased neuro-inflammatory response. Food Drug Administration United States has authorized various drugs for effective treatment AD, include galantamine, rivastigmine, donepezil, memantine, sodium oligomannate, lecanemab, aducanumab. major disadvantage these that they only provide "symptomatic" relief. They are most early stages or mild to moderate cases disease, but not suitable long-term use. Besides conventional therapies, phytochemicals have potential stop progression AD. According research, use against gained attention due their potent anti-inflammatory, antioxidant, anti-hyperphosphorylation protein, metal chelation, anti-amyloid properties. This study seeks an up-to-date compilation current promising breakthroughs therapy using phytochemicals. It could be concluded light serve as However, more mechanistic investigations needed determine clinical implications treatment.

Язык: Английский

Процитировано

1
The role of iron transporters and regulators in Alzheimer’s disease and Parkinson’s disease: Pathophysiological insights and therapeutic prospects DOI Open Access
Siqi Tian, Bing Wang,

Yiqian Ding

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117419 - 117419

Опубликована: Сен. 8, 2024

Язык: Английский

Процитировано

6
Role of Copper and Zinc Ions in the Hydrolytic Degradation of Neurodegeneration-Related Peptides DOI Creative Commons
Valentina Pirota, Enrico Monzani, Simone Dell’Acqua

и другие.

Molecules, Год журнала: 2025, Номер 30(2), С. 363 - 363

Опубликована: Янв. 17, 2025

Spontaneous cleavage reactions normally occur in vivo on amino acid peptide backbones, leading to fragmentation products that can have different physiological roles and toxicity, particularly when the substrate of hydrolytic processes are neuronal peptides proteins highly related neurodegeneration. We report a study performed with HPLC-MS technique at temperatures (4 °C 37 °C) fragments (amyloid-β, tau, α-synuclein) conditions presence Cu2+ Zn2+ ions, two metal ions found millimolar concentrations amyloid plaques. The coordination these significantly protects their backbones toward degradation, preserving entire sequences over weeks solution, while free same buffer fully fragmented after or even shorter incubation period. Our data show is not only ruled by chemical sensitivity acids, but conformation changes induced influence reactions. enhanced stability provided increase local levels amyloidogenic species capable seeding fibril growth, resulting aberrant protein depositions deficits activity.

Язык: Английский

Процитировано

0
Investigating cuproptosis and mitochondrial dysfunction in brain cells: uncovering novel mechanisms and biomarkers for Parkinson’s disease DOI

Q. Li,

Dongliang Li, Yinghong Li

и другие.

Metabolic Brain Disease, Год журнала: 2025, Номер 40(3)

Опубликована: Март 12, 2025

Язык: Английский

Процитировано

0
Nanomaterial-based approaches to neurotoxin neutralization in neurodegenerative diseases DOI
Meng Cheng, Yan Dou

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 13

Опубликована: Апрель 3, 2025

Neurodegenerative diseases (NDs) are intricately linked to the accumulation of various neurotoxins, mainly including toxic proteins, inflammatory mediators, excess metal ions, and viral pathogens. Biological neutralization strategies that use agents competitively bind harmful substances thus inhibit their pathogenic activity hold promise for direct removal neurotoxins but face many limitations challenges in NDs. Nanomaterials provide a potential solution neurotoxin NDs due unique physicochemical biological properties. This review summarizes recent advancements nanomaterial-based approaches NDs, highlighting diverse design principles mechanisms action. We also discuss critical role targeted delivery optimize efficiency advantages combining different or introducing other therapeutic components exert synergistic effects. Furthermore, we reveal current future research directions aimed at paving way nanomedicine development based on treatment

Язык: Английский

Процитировано

0
BIOMETALS IN NEURODEGENERATIVE DISEASES: THEIR BENEFICIAL AND DETRIMENTAL ROLES IN BRAIN HEALTH. DOI Open Access

TOBILOLA ODUNAYO AKINGBADE,

ELIJAH AYODELE OJO,

OPEYEMI PETER ADEBISI

и другие.

Greener Journal of Biomedical and Health Sciences, Год журнала: 2025, Номер 8(1), С. 16 - 27

Опубликована: Март 10, 2025

Biometals are essential to many physiological functions, including the normal functioning and development of brain. Notably, altered levels these biometals in body have been observed patients living with neurodegenerative conditions like Alzheimer’s, Huntington’s, Parkinson’s, Amyotrophic Lateral Sclerosis. This review will establish how can enter accumulate mechanisms for exhibiting neurotoxic effects. Correlations between level other non-essential metals existence diseases make them worthy study. Researchers looked toward biometal homeostasis as potential sources biomarkers, diagnostic breakthroughs, therapeutic solutions conditions. In addition, we explore benefit brain health, their role conditions, next frontiers biometal-based diagnostics therapy research.

Язык: Английский

Процитировано

0
Protective Contribution of Rosmarinic Acid in Rosemary Extract Against Copper-Induced Oxidative Stress DOI Creative Commons
Arian Kola, Ginevra Vigni, Stefania Lamponi

и другие.

Antioxidants, Год журнала: 2024, Номер 13(11), С. 1419 - 1419

Опубликована: Ноя. 19, 2024

Rosemary extract (

Язык: Английский

Процитировано

3
NMR-Based Structural Insights on Folic Acid and Its Interactions with Copper(II) Ions DOI Creative Commons
Arian Kola, Daniela Valensin

Inorganics, Год журнала: 2024, Номер 12(9), С. 248 - 248

Опубликована: Сен. 12, 2024

Folic acid (FA) is an essential vitamin involved in crucial metabolic processes, while copper(II) ions play significant roles various biological functions. This study aims to investigate the interaction between FA and Cu2+ using 1H 13C NMR spectroscopy under different pH levels concentrations. The research employed detailed analysis explore how binds FA, focusing on changes chemical shifts, diffusion coefficients, copper-induced paramagnetic effects. key findings reveal that predominantly coordinates with pteridine ring (PTE) of minimal involvement from glutamic (Glu) moiety. strongly concentration-dependent: at lower concentrations, effectively PTE ring, higher intermolecular interactions among molecules hinder copper binding. also observed pronounced effects p-aminobenzoic protons, negligible Glu signals. These results provide new insights into structural characteristics FA-Cu2+ complexes, contributing a better understanding their biochemical implications for folate metabolism.

Язык: Английский

Процитировано

1
AI/ML-driven nanocarriers for the management of neurodegeneration DOI

N. Vishal Gupta,

M Murugan,

Smruta Shanbhag

и другие.

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 361 - 372

Опубликована: Ноя. 29, 2024

Язык: Английский

Процитировано

1
Alterations in Zinc, Copper, and Iron Levels in the Retina and Brain of Alzheimer's Disease Patients and the APP/PS1 Mouse Model DOI Creative Commons
S. Mostafa Hosseinpour-Mashkani, David Bishop, Mika T. Westerhausen

и другие.

Metallomics, Год журнала: 2024, Номер 16(12)

Опубликована: Ноя. 8, 2024

Abstract Transition metals like copper (Cu), iron (Fe), and zinc (Zn) are vital for normal central nervous system function also linked to neurodegeneration, particularly in the onset progression of Alzheimer's disease (AD). Their alterations AD, identified prior amyloid plaque aggregation, offer a unique target staging pre-amyloid AD. However, analysing their levels brain is extremely challenging, necessitating development alternative approaches. Here, we utilized laser ablation–inductively coupled plasma–mass spectrometry solution nebulization–inductively quantitatively measure Cu, Fe, Zn concentrations retina hippocampus samples obtained from human donors (i.e. AD healthy controls), precursor protein/presenilin 1 (APP/PS1) mouse model wild-type (WT) controls, aged 9 18 months. Our findings revealed significantly elevated (*P < .05, P .01, .001) *P .05) compared controls. Conversely, APP/PS1 models exhibited notably lower metal same regions WT mice—Cu, (**P **P .05). The contrasting profiles samples, yet similar patterns within each species’ brain, suggest mirrors cerebral dyshomoeostasis lay groundwork pre-AD pathophysiology through assessment transition retina.

Язык: Английский

Процитировано

0