Evaluation of Antimicrobial Properties and Antioxidant Activity of Rosmarinic Acid-Loaded Resomer RG 502 H-Based Nanoparticles Against Tert-Butyl Hydroperoxide-Induced Oxidative Stress: A detailed formulation, characterization and efficacy determination study

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106721 - 106721

Опубликована: Фев. 1, 2025

Язык: Английский

NMR Metabolomic Profiling of Differentiated SH-SY5Y Neuronal Cells: Amyloid-β Toxicity and Protective Effects of Galantamine and Lycorine

Cells, Год журнала: 2025, Номер 14(7), С. 525 - 525

Опубликована: Апрель 1, 2025

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by metabolic dysregulation, oxidative stress, amyloid-β (Aβ) aggregation, metal dyshomeostasis, and mitochondrial dysfunction. Current treatments provide only symptomatic relief, highlighting the need for novel therapeutic strategies. This study investigates effects of alkaloids galantamine (GAL) lycorine (LYC) in differentiated SH-SY5Y neuroblastoma cells, an established vitro model AD, which acquire neuronal phenotype upon differentiation. Using untargeted targeted NMR-based metabolomics combined with multivariate statistical analysis, we analyzed extracellular profiles under basal conditions following Aβ42 exposure, both presence absence GAL LYC. Our findings reveal distinct responses to Aβ toxicity, significant alterations pyruvate glutamine metabolism. Both LYC contributed restoration lysine homeostasis, but had more pronounced effect, better sustaining cellular energy balance function. Unlike LYC, treatment was associated accumulation, response between two compounds. These variations may reflect mechanisms action, potentially influencing their roles counteracting Aβ-induced toxicity. highlights value profiling assessing neuroprotective agents reinforces potential natural this context.

Язык: Английский

Reevaluating Alzheimer’s disease treatment: Can phytochemicals bridge the therapeutic Gap?

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский