Plant Secondary Metabolites as Modulators of Mitochondrial Health: An Overview of Their Anti-Oxidant, Anti-Apoptotic, and Mitophagic Mechanisms
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(1), С. 380 - 380
Опубликована: Янв. 4, 2025
Plant
secondary
metabolites
(PSMs)
are
a
diverse
group
of
bioactive
compounds,
including
flavonoids,
polyphenols,
saponins,
and
terpenoids,
which
have
been
recognised
for
their
critical
role
in
modulating
cellular
functions.
This
review
provides
comprehensive
analysis
the
effects
PSMs
on
mitochondrial
health,
with
particular
emphasis
therapeutic
potential.
Emerging
evidence
shows
that
these
improve
function
by
reducing
oxidative
stress,
promoting
biogenesis,
regulating
key
processes
such
as
apoptosis
mitophagy.
Mitochondrial
dysfunction,
hallmark
many
pathologies,
neurodegenerative
disorders,
cardiovascular
diseases,
metabolic
syndrome,
has
shown
to
benefit
from
protective
PSMs.
Recent
studies
show
can
dynamics,
stabilise
membranes,
enhance
bioenergetics,
offering
significant
promise
prevention
treatment
mitochondrial-related
diseases.
The
molecular
mechanisms
underlying
effects,
modulation
signalling
pathways
direct
interactions
proteins,
discussed.
integration
into
strategies
is
highlighted
promising
avenue
improving
efficacy
while
minimising
side
commonly
associated
synthetic
drugs.
also
highlights
need
future
research
elucidate
specific
roles
individual
synergistic
within
complex
plant
matrices,
may
further
optimise
utility.
Overall,
this
work
valuable
insights
health
potential
natural
agents
targeting
dysfunction.
Язык: Английский
IUPHAR Review - Novel therapeutic targets for schizophrenia treatment: a translational perspective
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107690 - 107690
Опубликована: Март 1, 2025
Schizophrenia
is
a
severe
and
debilitating
psychiatric
disorder
that
profoundly
impacts
cognitive,
emotional,
social
functioning.
Despite
its
devastating
personal
societal
toll,
current
treatments
often
provide
only
partial
relief,
underscoring
the
urgent
need
for
innovative
therapeutic
strategies.
This
review
explores
emerging
approaches
target
complex
neurobiological
underpinnings
of
schizophrenia,
moving
beyond
traditional
dopamine-centric
models.
Among
these,
some
novel
drugs
still
employ
multimodal
mechanisms,
simultaneously
targeting
dopaminergic
serotonergic
systems
to
enhance
efficacy
tolerability.
Given
well-documented
excitatory/inhibitory
imbalance
in
significant
efforts
have
been
directed
toward
addressing
NMDA
receptor
hypofunctionality.
However,
strategies
this
pathway
yet
demonstrate
consistent
clinical
efficacy.
In
contrast,
therapies
cholinergic
system
shown
greater
promise.
For
instance,
xanomeline-trospium
combination,
which
modulates
muscarinic
receptors,
has
recently
gained
approval,
other
molecules
with
similar
mechanisms
are
currently
under
development.
Beyond
these
approaches,
being
explored
pathways,
including
neuroplasticity,
neuroinflammation,
mitochondrial
dysfunction.
These
designed
as
part
combinatorial
strategy
available
antipsychotic
drugs.
progress,
challenges
remain
translating
experimental
discoveries
into
effective
applications.
Future
research
should
prioritize
biomarker-driven
precision
medicine
optimize
individualized
treatment
outcomes.
By
integrating
targets,
schizophrenia
may
evolve
more
comprehensive
personalized
approach,
disorder's
full
spectrum
symptoms
improving
patient
quality
life.
Язык: Английский
Unraveling the role of Nrf2 in dopaminergic neurons: a review of oxidative stress and mitochondrial dysfunction in Parkinson’s disease
Metabolic Brain Disease,
Год журнала:
2025,
Номер
40(2)
Опубликована: Фев. 11, 2025
Язык: Английский
Nanoparticle‐Based Therapeutics for Glioblastoma Multiforme Treatment
Advanced Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Abstract
Glioblastoma
multiforme
(GBM)
is
a
grade
4
primary
malignant
brain
neoplasm
with
poor
prognosis.
GBM
has
an
average
survival
of
12–18
months
despite
aggressive
treatments,
such
as
maximal
safe
resection,
radiation,
and
chemotherapy
temozolomide.
always
associated
high
incidences
treatment
resistance
recurrence,
which
largely
driven
by
glioma
stem
cells
presents
significant
therapeutic
challenges.
The
blood–brain
barrier
(BBB)
the
most
obstacle
in
treating
since
it
restricts
delivery
agents
to
tumor
site.
Recent
advancements
nanotechnology
offer
promising
alternatives
overcome
restrictions,
enabling
targeted
drug
significantly
reducing
systemic
toxicity.
Additionally,
discussing
various
types
nanoparticles
liposomes,
lipid‐based,
dendrimers,
polymeric,
metallic
that
have
shown
promise
preclinical
models
for
become
pertinent.
These
can
attach
glioblastoma
using
antigens
membrane
receptors
site‐directed
targeting.
Furthermore,
potential
cross
BBB,
enhancing
minimizing
off‐target
effects.
This
review
explores
latest
nanoparticle‐based
therapies
their
revolutionize
treatment,
particularly
through
precise
targeting
controlled
release
within
microenvironment.
Язык: Английский
Update on the correlation between mitochondrial function and osteonecrosis of the femoral head osteocytes
Redox Report,
Год журнала:
2025,
Номер
30(1)
Опубликована: Апрель 18, 2025
Mitochondrial
health
is
maintained
in
a
steady
state
through
mitochondrial
dynamics
and
autophagy
processes.
Recent
studies
have
identified
healthy
mitochondria
as
crucial
regulators
of
cellular
function
survival.
This
process
involves
adenosine
triphosphate
(ATP)
synthesis
by
oxidative
phosphorylation
(OXPHOS),
regulation
calcium
metabolism
inflammatory
responses,
intracellular
stress
management.
In
the
skeletal
system,
they
participate
behaviors
responses
osteoblasts,
osteoclasts,
chondrocytes,
osteocytes
to
external
stimuli.
Indeed,
damage
or
dysfunction
occurs
development
few
bone
diseases.
For
example,
may
lead
an
imbalance
osteoblasts
resulting
osteoporosis,
osteomalacia,
poor
production,
chondrocyte
death
infiltration
osteoarthritis
are
main
causes
cartilage
degeneration
due
damage.
However,
opposite
exists
for
osteosarcoma,
where
overactive
able
accelerate
proliferation
migration
osteosarcoma
cells,
which
major
disease
feature.
Bone
dynamic
organ
play
fundamental
role
all
regions
tissue
involved
regulating
integrity.
review
examines
impact
physiological
on
osteocyte
summarizes
microscopic
molecular
mechanisms
underlying
its
effects.
It
highlights
that
targeted
therapies
focusing
be
beneficial
survival,
providing
new
insight
diagnosis,
prevention,
treatment
diseases
associated
with
death.
Язык: Английский
Mitochondrial Protective Effects of Black Goji Berry Anthocyanins in Caenorhabditis elegans: Defenses Against Oxidative Stress
Food Bioscience,
Год журнала:
2024,
Номер
unknown, С. 105721 - 105721
Опубликована: Дек. 1, 2024
Язык: Английский
Extraction, Detection, Bioactivity, and Product Development of Luteolin: A Review
Fajian Ren,
Ying Li,
Hanyuan Luo
и другие.
Heliyon,
Год журнала:
2024,
Номер
10(24), С. e41068 - e41068
Опубликована: Дек. 1, 2024
Luteolin
is
a
kind
of
natural
flavonoid,
widely
existing
in
variety
plants,
has
been
revealed
to
have
wide
range
biological
activities.
In
recent
years,
the
research
results
luteolin
are
abundant.
Here
we
review
latest
order
provide
new
ideas
for
further
and
development
luteolin.
this
paper,
focus
search
was
published
between
2010
2024
on
extraction
determination
luteolin,
activities,
application
products.
A
comprehensive
using
keyword
"luteolin"
conducted
PubMed,
Web
Science
WIPO
databases.
Through
collection
related
literature,
paper
summarized
techniques
including
immersion
extraction,
solvent
ultrasonic-assisted
supercritical
fluid
so
on.
The
methods
include:
thin
layer
chromatography
(TLC),
high
performance
liquid
(HPLC),
capillary
electrophoresis
(CE),
electrochemical
method
(ED)
addition,
activities
antioxidant,
anti-inflammatory,
anti-tumor,
antibacterial,
analgesic
on,
were
described.
And
as
main
component
product
being
gradually
developed,
used
field
food,
medicine
cosmetics.
This
provides
reference
study
Язык: Английский