Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 9, 2025

Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, potentially cancer. This closely associated with disorders driven overnutrition, key pathological processes dysregulation, impaired autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, local inflammation. While hepatic metabolism in well-documented, further research into communication mechanisms crucial for deeper understanding of progression. review delves intrahepatic networks tissue-specific signaling mediators involved pathogenesis, emphasizing their impact on distal organs.

Язык: Английский

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Risk factors for decreased bone mineral density in patients with metabolic dysfunction-associated steatotic liver disease: A cross-sectional study at a health examination center

Clinical Nutrition, Год журнала: 2024, Номер 43(6), С. 1425 - 1432

Опубликована: Апрель 29, 2024

Background & Aims Steatotic liver disease (SLD) is often detected in health examinations. However, although individuals with metabolic dysfunction-associated SLD (MASLD) may have decreased bone mineral density (BMD), the specific risk factors remain unclarified. The objective of this study was to identify associated BMD patients MASLD. Methods Individuals who underwent abdominal ultrasonography and measurements at our healthcare center were included. calcaneus assessed using an AOS-10SA densitometer. Decreased defined as a T-score below -1.0 SD or administration osteoporosis treatment. diagnosed based on ultrasonographic criteria. Results A total 1,410 median age 52 years. Multivariate analysis logistic regression model revealed that independent predictors low body mass index (BMI) small waist circumference (odds ratio (OR): 0.48, 95% confidence interval (CI): 0.34–0.67), hypertriglyceridemia (OR: 1.29, CI: 1.00–1.65), weak grip strength 0.98, 0.97–1.00). Subgroup analyses aged 50 years older, men, FIB-4 1.3 greater absence high BMI large BMD. subgroup men weaker Conclusion present suggested several potential for abovementioned should be encouraged undergo measurement from perspective preventive medicine.

Язык: Английский

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Associations of metabolic dysfunction-associated fatty liver disease and hepatic fibrosis with bone mineral density and risk of osteopenia/osteoporosis in T2DM patients

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Дек. 4, 2023

Background Existing evidence on the associations of liver steatosis and fibrosis with bone mineral density (BMD) risk osteopenia/osteoporosis was limited conflicting results. We aimed to evaluate metabolic dysfunction-associated fatty disease (MAFLD) hepatic BMD in type 2 diabetes mellitus (T2DM) patients. Methods Baseline information an ongoing cohort 249 T2DM patients Xiamen, China analyzed. MAFLD defined as presence [diagnosed by either ultrasonography scanning or index (FLI) score >60] for measured using dual-energy x-ray absorptiometry at total lumbar (L2–4), femur neck (FN), hip (TH) categorized normal (T ≥ −1.0), osteopenia (−2.5 < T osteoporosis ≤ −2.5) according its minimum T-score. Results Among patients, prevalence rates MAFLD, osteopenia, were 57.8%, 50.6%, 17.7%, respectively. Patients had significantly higher T-scores L2–4, FN, TH well lower than without MAFLD. Hepatic indices, including FLI score, (FLI 60 scanning), positively associated all T-scores, while FIB-4 but not NAFLD (NFS), negatively T-scores. decreased unadjusted odds ratios (ORs) (95% CI) 0.565 (0.324–0.987) 0.434 (0.224–0.843) (both p -values 0.05), As fibrosis, NFS, elevated OR per SD increase 1.446 (1.080–1.936, -value = 0.013). Adjusting potential confounding variables, especially body mass index, multivariable regression analyses, indices statistically significant. Conclusion independent obesity. Nevertheless, screening management still important prevention fracture

Язык: Английский

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Association of chronic liver disease with bone diseases and muscle weakness

Journal of Bone and Mineral Metabolism, Год журнала: 2024, Номер 42(4), С. 399 - 412

Опубликована: Фев. 1, 2024

Язык: Английский

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The relationship between advanced liver fibrosis and osteoporosis in type 2 diabetes patients with MAFLD

Endocrine, Год журнала: 2024, Номер 85(1), С. 206 - 221

Опубликована: Фев. 17, 2024

Язык: Английский

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Effects of Metabolic Dysfunction-Associated Steatotic Liver Disease on Bone Density and Fragility Fractures: Associations and Mechanisms

Journal of Obesity & Metabolic Syndrome, Год журнала: 2024, Номер 33(2), С. 108 - 120

Опубликована: Май 14, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) has profound adverse effects on bone health and homeostasis. MASLD appears to be associated with changes in mineral density (BMD) fracture rate. However, the data are ambiguous conflicting. Although several studies have shown that children adolescents decreased BMD, prevalence of fragility fractures among scarce. In adults, increasing evidence suggests decreases BMD increases risk fractures, which due deterioration architecture addition a decrease BMD. Effects may also age- race-specific. does not seem increase but elderly men, especially those Asian origin. From mechanistic perspective, remodeling is continuous process between osteoblasts (bone-forming) osteoclasts (bone-resorbing), any imbalance resulting metabolic disease. individuals MASLD, loss anabolic insulin receptor signaling (insulin resistance) increased activator nuclear factor κB (RANK)/RANK ligand (proinflammatory cytokines) swings pendulum toward accelerated loss. These processes further complicated by concomitant presence obesity, type 2 diabetes mellitus, or sarcopenia MASLD. This study reviews current literature children/adolescents adults. review discusses pathomechanisms link fractures.

Язык: Английский

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Association Between Liver Fibrosis (FIB-4) Index and Vertebral Fracture in Middle-aged and Older Adults in the United States: A Cross-Sectional Study of NHANES 2013-2014

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Objective This study was to examine the association between FIB-4(fibrosis index based on four factors) and occurrence of vertebral fractures in Middle-aged Older Americans. Methods Patients ⩾45years age from 2013–2014 NHANES database were selected for this study. Restricted cubic spline models weighted logistic regression used assess FIB-4 The predictive value assessed using receiver operating characteristic curves (ROC). To robustness main findings, a sensitivity analysis conducted. Results A total 2188 patients included analysis, whole 147 suffered fractures. Fully adjusted showed significant linear relationship fracture Americans (P < 0.05),with observed risk Additionally, demonstrated good performance incidence Conclusions found that index, as novel non-invasive liver fibrosis biomarker, can predict middle-aged older Americans, which has clinical significance prevention management

Язык: Английский

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Association between liver fibrosis and osteoporosis in adults aged 50 and older: insights from the Bushehr Elderly Health Program

Journal of Diabetes & Metabolic Disorders, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 6, 2025

Язык: Английский

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Multifaceted environmental factors linked to metabolic dysfunction-associated fatty liver disease: an environment-wide association study

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 20, 2025

Environmental factors, or exposome, are non-negligible contributors to the occurrence and progression of metabolic dysfunction-associated fatty liver disease (MAFLD). Therefore, this environment-wide association study (EWAS) aimed investigate associations between multifarious environmental factors MAFLD among general adult population in United States. Eligible participants were obtained from National Health Nutrition Examination Survey 2005-2020 cycles. Survey-weighted multivariate logistic regression models constructed identify tentatively validate MAFLD-associated factors. The least absolute shrinkage selection operator (LASSO) was conducted validated with stronger MAFLD. Moreover, importance, discrimination power, correlation patterns, subgroup-specific differences, survey cycle heterogeneity identified further examined by multiple statistical strategies. A total 14,416 included EWAS. Among 511 candidate 167 validated, 45 preserved after LASSO evaluation. In study, most previously known replicated reduced bias, several poorly studied discovered, for example, upper leg length, access care, mid-upper arm circumference, trabecular bone score. Their ability, pairwise correlations, subgroup variations, across cycles systematically rigorously evaluated. This EWAS comprehensively explored a panoramic perspective. findings may provide clues understanding promote early prevention risk prediction strategies future.

Язык: Английский

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The association between the AST/ALT ratio and osteopenia or osteoporosis in patients with type 2 diabetes mellitus

Endocrine Connections, Год журнала: 2025, Номер 14(5)

Опубликована: Апрель 25, 2025

The aim of this study was to investigate the relationship between AST/ALT ratio and osteopenia or osteoporosis in patients with type 2 diabetes mellitus (T2DM). A total 589 T2DM were divided into two groups based on T-score: T-score ≥ -1.0 group, normal bone mineral density < (OP). association osteopenia/OP evaluated by multivariate analyses. receiver operating characteristic (ROC) curves used estimate diagnostic performance according area under ROC curve (AUC). group showed significantly higher level than those (0.93 ± 0.16 vs 1.17 0.24, P 0.001). According interquartile range ratio, participants four groups: Q1 (0.650, 0.874), Q2 (0.875, 0.999), Q3 (1.000, 1.173) Q4 (1.174, 1.917). After adjustment for confounding factors, compared level, subjects remained more likely have (Q3, OR 3.478, 95% CI 1.641-7.411; Q4, 15.278, 6.377-36.837). provided an AUC value 0.81 (95% 0.77-0.84) T2DM. An elevated is associated risk a practical cost-effective biomarker, may be potential predictor

Язык: Английский

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