Epidemiological dynamics of burden and health inequalities in metabolic dysfunction-associated steatotic liver disease in adolescents at global, regional, and national levels, 1990-2021
Journal of Clinical and Experimental Hepatology,
Год журнала:
2025,
Номер
unknown, С. 102537 - 102537
Опубликована: Фев. 1, 2025
Язык: Английский
Increased serum anti-angiogenic factor levels in insulin-resistant obese children and adolescents with or without liver steatosis (NAFL)
Samed Emre Darılmaz,
Melike Zeynep Tugrul Aksakal,
Gözde Ceylan
и другие.
Scandinavian Journal of Clinical and Laboratory Investigation,
Год журнала:
2025,
Номер
unknown, С. 1 - 6
Опубликована: Май 14, 2025
This
study
aimed
to
investigate
the
effect
of
obesity
on
angiogenesis
and
its
relationship
with
liver
steatosis
in
obese
children
adolescents.
The
ıncluded
81
ın
chıldren
30
healthy
controls.
Obese
subjects
were
subdıvıded
by
ultrasound
ınto
three
groups:
no
steatosıs,
grade
1
lıver
steatosıs
(NAFL),
2
NAFL.
individuals,
regardless
presence
NAFL,
exhibited
significant
insulin
resistance
(p
<
.01)
compared
their
lean
counterparts.
All
showed
elevated
serum
ALT,
wıth
a
sıgnıfıcantly
greater
those
Marked
dyslipidemia
decreased
high-density
lipoprotein
(HDL)
levels
triglycerides,
was
observed
individuals
angiopoietin-1
(Ang-1)
vascular
endothelial
growth
factor-165b
(VEGF165b)
measured
as
anti-angiogenic
markers,
while
factor-A
(VEGF-A),
fibroblast
factor-2
(FGF-2)
P-selectin
assessed
pro-angiogenic
factors.
Compared
normal-weight
(5558
±
674
pg/mL),
Ang-1
significantly
all
subgroups
(8861
1026;
8105
615;
7388
924,
respectıvely).
However,
differences
among
subgroups.
VEGF165b
higher
insulin-resistant
(7575
747
pg/mL
293
44.4
pg/mL,
respectively)
insulin-sensitive
(6143
557
179
31.4
respectively).
These
findings
suggest
that
is
associated
altered
angiogenic
signaling.
factors
between
groups
without
Язык: Английский
Draft Clinical Guidelines for the Diagnosis and Treatment of Metabolically Associated Fatty Liver Disease in Children (Non-Alcoholic Fatty Liver Disease)
Педиатрическая фармакология,
Год журнала:
2025,
Номер
22(2), С. 147 - 163
Опубликована: Май 23, 2025
The
authors
present
modern
epidemiological
data
and
features
of
the
etiopathogenesis
metabolically
associated
fatty
liver
disease
in
children
(non-alcoholic
disease),
provide
clinical
characteristics
various
variants
this
nosology.
Information
is
provided
on
laboratory,
instrumental
morphological
signs
children,
as
well
methods
prevention,
treatment
rehabilitation
accordance
with
developed
guidelines.
Язык: Английский