Increased serum anti-angiogenic factor levels in insulin-resistant obese children and adolescents with or without liver steatosis (NAFL) DOI

Samed Emre Darılmaz,

Melike Zeynep Tugrul Aksakal,

Gözde Ceylan

et al.

Scandinavian Journal of Clinical and Laboratory Investigation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 6

Published: May 14, 2025

This study aimed to investigate the effect of obesity on angiogenesis and its relationship with liver steatosis in obese children adolescents. The ıncluded 81 ın chıldren 30 healthy controls. Obese subjects were subdıvıded by ultrasound ınto three groups: no steatosıs, grade 1 lıver steatosıs (NAFL), 2 NAFL. individuals, regardless presence NAFL, exhibited significant insulin resistance (p < .01) compared their lean counterparts. All showed elevated serum ALT, wıth a sıgnıfıcantly greater those Marked dyslipidemia decreased high-density lipoprotein (HDL) levels triglycerides, was observed individuals angiopoietin-1 (Ang-1) vascular endothelial growth factor-165b (VEGF165b) measured as anti-angiogenic markers, while factor-A (VEGF-A), fibroblast factor-2 (FGF-2) P-selectin assessed pro-angiogenic factors. Compared normal-weight (5558 ± 674 pg/mL), Ang-1 significantly all subgroups (8861 1026; 8105 615; 7388 924, respectıvely). However, differences among subgroups. VEGF165b higher insulin-resistant (7575 747 pg/mL 293 44.4 pg/mL, respectively) insulin-sensitive (6143 557 179 31.4 respectively). These findings suggest that is associated altered angiogenic signaling. factors between groups without

Language: Английский

Epidemiological dynamics of burden and health inequalities in metabolic dysfunction-associated steatotic liver disease in adolescents at global, regional, and national levels, 1990-2021 DOI

Xiaohui Sui,

Junde Zhao, Yuxin Yang

et al.

Journal of Clinical and Experimental Hepatology, Journal Year: 2025, Volume and Issue: unknown, P. 102537 - 102537

Published: Feb. 1, 2025

Language: Английский

Citations

0
Increased serum anti-angiogenic factor levels in insulin-resistant obese children and adolescents with or without liver steatosis (NAFL) DOI

Samed Emre Darılmaz,

Melike Zeynep Tugrul Aksakal,

Gözde Ceylan

et al.

Scandinavian Journal of Clinical and Laboratory Investigation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 6

Published: May 14, 2025

This study aimed to investigate the effect of obesity on angiogenesis and its relationship with liver steatosis in obese children adolescents. The ıncluded 81 ın chıldren 30 healthy controls. Obese subjects were subdıvıded by ultrasound ınto three groups: no steatosıs, grade 1 lıver steatosıs (NAFL), 2 NAFL. individuals, regardless presence NAFL, exhibited significant insulin resistance (p < .01) compared their lean counterparts. All showed elevated serum ALT, wıth a sıgnıfıcantly greater those Marked dyslipidemia decreased high-density lipoprotein (HDL) levels triglycerides, was observed individuals angiopoietin-1 (Ang-1) vascular endothelial growth factor-165b (VEGF165b) measured as anti-angiogenic markers, while factor-A (VEGF-A), fibroblast factor-2 (FGF-2) P-selectin assessed pro-angiogenic factors. Compared normal-weight (5558 ± 674 pg/mL), Ang-1 significantly all subgroups (8861 1026; 8105 615; 7388 924, respectıvely). However, differences among subgroups. VEGF165b higher insulin-resistant (7575 747 pg/mL 293 44.4 pg/mL, respectively) insulin-sensitive (6143 557 179 31.4 respectively). These findings suggest that is associated altered angiogenic signaling. factors between groups without

Language: Английский

Citations

0