Global burden of metabolic diseases, 1990–2021

Metabolism, Год журнала: 2024, Номер 160, С. 155999 - 155999

Опубликована: Авг. 14, 2024

Язык: Английский

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Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1354 - 1354

Опубликована: Окт. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Язык: Английский

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Global burden and risk factors of MASLD: trends from 1990 to 2021 and predictions to 2030

Internal and Emergency Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Abstract The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing globally, posing a major public health issue. This study analyzes the global, regional, and national burden MASLD its risk factors from 1990 to 2021, with projections 2030. We obtained data on prevalence, deaths, disability-adjusted life years (DALYs) Global Burden Disease 2021 for 204 countries. Counts rates per 100,000 population were calculated, trends 2030 predicted using Bayesian Age-Period-Cohort model. In there 1,267.9 million cases 138.3 thousand deaths 3667.3 DALYs. global age-standardized death, DALY 15,018.1, 1.6, 42.4 population, by 24.3%, 5.5%, 5.5% since 1990. North Africa Middle East had highest while Andean Central Latin America death rates. Men aged 15–69 90–94 higher rates, women 70–89 95+ A reversed V-shaped association was found between sociodemographic index rate. High fasting plasma glucose (5.9%) smoking (2.4%) factors. Public efforts should prioritize early detection management in younger populations develop targeted strategies older adults, especially women, reduce burden. Effective policies address high can mitigate MASLD’s impact.

Язык: Английский

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Causal link between dietary antioxidant vitamins intake, oxidative stress injury biomarkers and colorectal cancer: A Mendelian randomization study

Medicine, Год журнала: 2025, Номер 104(7), С. e41531 - e41531

Опубликована: Фев. 14, 2025

Oxidative stress and reactive oxygen species play a pivotal role in carcinogenesis. Recent studies have indicated potential reduction cancer incidence associated with antioxidant intake; however, these results remain controversial. We performed 2-sample Mendelian randomization (MR) analysis to explore the causal relationship between dietary vitamins (retinol, carotene, vitamin C, E), oxidative injury biomarkers (GST, CAT, SOD, GPX), risk of colorectal (CRC). The genetic instrumental variants (IVs) that had previously shown significant association were screened from UK Biobank relevant published studies. genome-wide study (GWAS) data for total colorectal, colon, rectal obtained FinnGen cohort. primary MR employed inverse-variance-weighted (IVW) method. Furthermore, sensitivity was assess heterogeneity horizontal pleiotropy. revealed no associations vitamins, biomarkers, CRC. odds ratios (ORs) as follows: 1.22 (95% confidence interval (CI): 0.65–2.28, P = .53) retinol, 0.77 CI: 0.50–1.18, .24) 0.82 0.42–1.63, .58) 1.20 0.86–1.68, .28) E. Regarding ORs 0.99 0.93–1.06, .88) GST, 0.93–1.05, .65) 1.02 0.95–1.09, .57) 1.01 0.95–1.07, .76) GPX. Likewise, stratified by tumor site beneficial effects colon cancers. Our findings indicate elevated levels diet-related well injury, do not provide protective effect against CRC risk.

Язык: Английский

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Dual etiology vs. MetALD: how MAFLD and MASLD address liver diseases coexistence

Metabolism and Target Organ Damage, Год журнала: 2025, Номер 5(1)

Опубликована: Март 27, 2025

Fatty liver disease associated with metabolic dysfunction has emerged as a significant global health challenge. This condition often coexists other diseases, such alcohol-related and viral hepatitis, complicating both diagnosis management. To address the limitations of non-alcoholic fatty (NAFLD) classification, two alternative frameworks have been proposed: dysfunction-associated (MAFLD) in 2020 steatotic (MASLD) 2023. A key difference between these definitions is how they consider relation to coexistence conditions. MAFLD adopts dual etiology concept, creating unified classification system that aligns contemporary clinical epidemiological needs. In contrast, MASLD introduces new term, MetALD (metabolic alcohol-related/associated disease), describe patients who excessive alcohol intake. review critically examines clinical, research, implications differing approaches MASLD, offering insights into their potential enhance understanding management multi-etiology diseases.

Язык: Английский

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Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease

Antioxidants, Год журнала: 2024, Номер 13(11), С. 1386 - 1386

Опубликована: Ноя. 14, 2024

Background: The gut microbiota constitutes a complex microorganism community that harbors bacteria, viruses, fungi, protozoa, and archaea. human bacterial has been extensively proven to participate in metabolism, immunity, nutrient absorption. Its imbalance, namely “dysbiosis”, linked disordered metabolism. Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the features deranged metabolism leading cause cirrhosis hepatocellular carcinoma. Thus, there pathophysiological link between dysbiosis MASLD. Aims Methods: We aimed review literature data on composition its MASLD describe concept “gut–liver axis”. Moreover, we reviewed approaches for modulation treatment. Results: There consolidated evidence particular associated with stages. model explaining relationship bidirectional organization, physiopathology Oxidative stress keystones pathophysiology fibrosis generation. promising efficacy pre- probiotics reversing patients, therapeutic effects. Few yet encouraging fecal transplantation (FMT) are available literature. Conclusions: characteristic key target reversal treatment via diet, pre/probiotics, FMT remains treatment, prevention, reversal.

Язык: Английский

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The association between working hours and working type with non-alcoholic fatty liver disease: results from the NHANES 1999-2014

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 14, 2025

Background Previous research has indicated that long working hours are connected to a variety of health conditions, including nonalcoholic fatty liver disease (NAFLD). However, this association which been observed in more population is limited. Our designed evaluate the between hours, type, and NAFLD. Methods The study comprised adults with complete details on NAFLD from NHANES 1999-2014. We employed hepatic steatosis index (HSI) examined relationship or type using weighted multiple-variable regression models restricted cubic spline (RCS) analysis. In addition, further subgroup analysis was performed based sex, age, ratio family income poverty (PIR), education, diabetes. Results Long were significantly linked an elevated risk (OR: 1.57, 95%CI: 1.21-2.05), even after controlling for confounding factors. RCS suggested there no nonlinear them. When weekly > 50, likelihood among heightened 57% increased 99% female population. As increasing physical intensity work associated higher risk, but only heavy manual labor continued show significance adjustment (OR:1.39, 1.06-1.81). significant older male populations. Conclusion results indicate engaging independent factors increase individuals engage extended periods, developing rises.

Язык: Английский

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The Impact of Incidental Hepatocellular Carcinoma in Liver Transplantation: A Growing Concern

Clinics and Research in Hepatology and Gastroenterology, Год журнала: 2025, Номер 49(3), С. 102550 - 102550

Опубликована: Фев. 6, 2025

Язык: Английский

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Insulin resistance and cancer: molecular links and clinical perspectives

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 15, 2025

Язык: Английский

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Dynamic Status of Systemic Immune Inflammation Index Is Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease: An Evidence From a Ten-Year Prospective Longitudinal Cohort Study

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 4595 - 4606

Опубликована: Апрель 1, 2025

Previous research studies have linked the systemic immune inflammation index (SII), derived from a complete blood count, to metabolic dysfunction-associated steatotic liver disease (MASLD). However, evidence on relationship between longitudinal changes in SII and MASLD remains limited. This study aimed explore distinct trajectories their association with incidence. A analyzed 25,600 individuals who underwent periodic health assessments at Dalian City hospital 2014 2023. was diagnosed via ultrasound. The calculated using formula = (platelet count × neutrophil count) / lymphocyte count. Group-based trajectory modeling used identify trajectories, restricted cubic spline (RCS) analysis employed assesse dose-response relationship. Stratified analyses sensitivity were also conducted. Three identified: "low stable" (50.6%), "moderate (35.1%), "high (8.9%). After adjustments, hazard ratios (HR) for incidence 1.118 (95% CI: 1.057-1.182, P<0.001) group 1.284 1.172-1.408, group. These associations persisted after adjusting lifestyle factors. significant non-linear risk found both overall population among different genders. Subgroup consistently confirmed these findings. Elevated levels are significantly associated an increased of MASLD, particularly under 45 women. Regular monitoring may improve stratification facilitate targeted prevention strategies those higher MASLD.

Язык: Английский

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