The Journals of Gerontology Series A,
Год журнала:
2023,
Номер
79(2)
Опубликована: Окт. 5, 2023
Abstract
Aging
is
characterized
by
chronic
low-level
inflammation
and
associated
with
geriatric
syndromes
such
as
sarcopenia
frailty.
Our
aim
was
to
evaluate
the
longitudinal
variation
of
muscle
area,
quality,
strength,
relative
leukocyte-derived
markers,
assess
presence
a
pathway
associations
among
derived
leukocyte
ratios,
components
health.
The
InCHIANTI
cohort
study
aging
that
began
in
1998
follow-up
visits
every
3
years.
Out
1
453
participants
enrolled
at
baseline,
this
includes
179
complete
data.
Muscle
strength
assessed
hand
grip
test,
whereas
density
fat
area
were
considered
indirect
markers
from
peripheral
quantitative
computed
tomography
calf.
neutrophil-to-lymphocyte
ratio
(NL-ratio),
age,
gender,
comorbidities,
body
mass
index
(BMI).
over
time
inversely
BMI,
while
being
positively
monocyte-to-lymphocyte
(ML-ratio)
male
gender.
Fat
interleukine-6
(IL-6),
NL-ratio,
ML-ratio,
BMI.
Handgrip
decreased
IL-6
levels,
but
increased
male,
having
higher
In
path-analysis
model,
ML-ratio
correlates
mass,
density,
NL-ratio
only
density.
are
may
be
implicated
age-related
mechanisms
affect
composition
strength.
These
ratios
represent
link
between
immune
system
decline
health
aging.
However,
further
studies
needed
identify
their
usefulness
for
early
detection
sarcopenia,
myosteatosis,
frailty
older
adult.
Metabolites,
Год журнала:
2024,
Номер
14(12), С. 672 - 672
Опубликована: Дек. 2, 2024
Background/Objectives:
LL-37
is
associated
with
metabolic
syndrome
(MetS),
a
constellation
of
risk
factors
comprising
obesity,
insulin
resistance
(IR),
dyslipidemia,
and
hypertension,
which
elevates
the
cardiovascular
disease
type
2
diabetes.
Methods:
In
this
narrative
review,
we
analyzed
literature
focusing
on
recent
developments
in
relationship
between
cathelicidin
various
components
MetS
to
provide
comprehensive
overview.
Results:
Studies
have
shown
that
linked
inflammation
adipose
tissue
(AT)
development
IR
obesity.
Cathelicidin
can
enhance
by
activating
pro-inflammatory
genes,
as
well
modulate
inflammatory
response.
The
mechanisms
include
activation
complex
signaling
pathways
induce
reduce
adipocytes.
Toll-like
receptors
(TLRs)
stimulates
secretion
cytokines,
contributing
disruption
function
cells.
also
influences
lipid
metabolism,
research
showing
negative
levels
HDL
cholesterol.
Therefore,
involved
not
only
regulation
but
potentially
aggravating
complications
MetS.
Conclusions:
plays
crucial
role
regulating
balance
anti-inflammatory
responses
Understanding
impact
these
may
unveil
novel
approaches
for
addressing
its
complications.
Genes & Development,
Год журнала:
2023,
Номер
37(17-18), С. 781 - 800
Опубликована: Сен. 1, 2023
Adipose
tissue
exhibits
a
remarkable
capacity
to
expand,
contract,
and
remodel
in
response
changes
physiological
environmental
conditions.
Here,
we
describe
recent
advances
our
understanding
of
how
functionally
distinct
tissue-resident
mesenchymal
stromal
cell
subpopulations
orchestrate
several
aspects
pathophysiological
adipose
remodeling,
with
particular
focus
on
the
adaptations
that
occur
energy
surplus
temperature.
The
study
remodeling
provides
vehicle
understand
functional
diversity
cells
offers
lens
through
which
generalizable
reorganization
can
be
readily
observed.
Current Opinion in Clinical Nutrition & Metabolic Care,
Год журнала:
2024,
Номер
27(4), С. 325 - 330
Опубликована: Апрель 19, 2024
Obesity
is
associated
with
increased
DNA
damage,
which
may
in
turn
contribute
to
the
development
of
obesity-related
complications.
damage
can
also
affect
adipocyte
biology,
resulting
adiposity.
Carefully
managed
weight
loss
programs
reverse
this
process.
This
article
surveys
new
data
that
support
these
contentions.
Immunometabolism,
Год журнала:
2024,
Номер
6(3), С. e00046 - e00046
Опубликована: Июль 1, 2024
In
recent
decades,
obesity
has
become
a
worldwide
epidemic.
As
result,
the
importance
of
adipose
tissue
(AT)
as
metabolically
active
storage
depot
for
lipids
and
key
mediator
body-wide
metabolism
energy
balance
been
increasingly
recognized.
Emerging
from
studies
AT
in
metabolic
disease
is
recognition
adipocyte
progenitor
cell
(APC)
population
being
gatekeeper
function.
APCs
have
capability
to
self-renew
undergo
adipogenesis
propagate
new
adipocytes
capable
lipid
storage,
which
important
maintaining
healthy
fat
pad,
devoid
dysfunctional
droplet
hypertrophy,
inflammation,
fibrosis,
linked
diseases,
including
type
2
diabetes.
Like
other
dividing
cells,
are
at
risk
undergoing
senescence,
state
irreversible
proliferation
arrest
that
occurs
under
variety
stress
conditions,
DNA
damage
telomere
attrition.
APC
controlled
by
factors,
paracrine
endocrine
quality
timing
intake,
circadian
clock
system.
Therefore,
alteration
any
underlying
signaling
pathways
resulting
excessive
can
lead
premature
senescence.
Better
understanding
senescence
mechanisms
will
interventions
extending
health.
AJP Cell Physiology,
Год журнала:
2024,
Номер
327(3), С. C698 - C715
Опубликована: Июль 1, 2024
Type
2
diabetes
(T2D)
constitutes
a
major
public
health
problem,
and
despite
prevention
efforts,
this
pandemic
disease
is
one
of
the
deadliest
diseases
in
world.
In
2022,
6.7
million
patients
with
T2D
died
prematurely
from
vascular
complications.
Indeed,
increases
risk
myocardial
infarction
or
stroke
eightfold.
The
identification
molecular
factors
involved
occurrence
cardiovascular
complications
their
are
therefore
axes.
Our
hypothesis
that
brought
into
play
during
physiological
aging
appear
progression.
study
focused
on
extracellular
matrix
(ECM),
element
maintenance
homeostasis.
We
characterized
morphological
functional
aspects
aorta,
focus
collagen
elastic
fibers
diabetic
mice
aged
6
mo
to
nondiabetic
20
mo.
comparison
two
models
(young
old)
highlighted
an
exacerbated
activity
proteases,
which
could
explain
disturbance
accumulation
excessive
degradation
fibers.
Moreover,
generation
circulating
elastin-derived
peptides
reflects
premature
ECM.
These
elements
contribute
appearance
rigidity,
often
origin
pathologies
such
as
hypertension
atherosclerosis.
conclusion,
we
show
present
same
characteristics
ECM
wear
those
observed
This
accelerated
aortic
wall
remodeling
then
early
onset
and,
therefore,
death
T2D.
Metabolites,
Год журнала:
2023,
Номер
14(1), С. 4 - 4
Опубликована: Дек. 20, 2023
Obesity
affects
more
than
one
billion
people
worldwide
and
often
leads
to
cardiometabolic
chronic
comorbidities.
It
induces
senescence-related
alterations
in
adipose
tissue,
senescence
is
closely
linked
obesity.
Fully
elucidating
the
pathways
through
which
vitamin
D
exerts
anti-inflammatory
effects
may
improve
our
understanding
of
local
tissue
inflammation
pathogenesis
metabolic
disorders.
In
this
narrative
review,
we
compiled
analyzed
literature
from
diverse
academic
sources,
focusing
on
recent
developments
provide
a
comprehensive
overview
effect
associated
with
obesity
senescence.
The
article
reveals
that
activation
NF-κB
(nuclear
factor
kappa
B
subunit
1)
NLRP3
inflammasome
(nucleotide-binding
domain,
leucine-rich-containing,
pyrin
domain-containing-3)
toll-like
receptors,
increases
oxidative
stress
cytokine
release,
common
mechanism
underlying
senescence,
it
discusses
potential
beneficial
alleviating
development
subclinical
inflammation.
Investigating
main
target
cells
action
could
help
uncover
complex
mechanisms
cellular
This
review
summarizes
significant
findings
related
opportunities
for
improving
health.
