Springer eBooks, Год журнала: 2023, Номер unknown, С. 383 - 403
Опубликована: Янв. 1, 2023
Язык: Английский
Molecular Metabolism, Год журнала: 2024, Номер 84, С. 101952 - 101952
Опубликована: Май 3, 2024
Solute carrier (SLC), a diverse family of membrane proteins, are instrumental in orchestrating the intake and efflux nutrients including amino acids, vitamins, ions, nutrients, etc, across cell membranes. This dynamic process is critical for sustaining metabolic demands cancer cells, promoting their survival, proliferation, adaptation to tumor microenvironment. Amino acids fundamental building blocks playing essential roles not only protein synthesis but also nutrient sensing, signaling pathways that can promote tumorigenesis. As key transporters SLCs have emerged as crucial players maintaining cellular acid homeostasis, dysregulation implicated various types. Thus, understanding intricate connections between SLCs, pivotal unraveling novel therapeutic targets strategies. uptake by positively affects progression. However, some studies revealed suppressor function SLCs. Although body evaluated SLC7A11 SLC1A5, SLC proteins studied sufficiently cancer. In this review, we delve into significant impact carriers on growth progression explore current state knowledge field, shedding light molecular mechanisms underlie these relationships highlighting potential avenues future research clinical interventions. comprehensive review provides insights rapidly evolving area biology focusing one most important materials cells need, within superfamily.
Язык: Английский
Процитировано
15
Biology, Год журнала: 2024, Номер 13(2), С. 122 - 122
Опубликована: Фев. 15, 2024
Ferroptosis is a non-apoptotic mode of cell death driven by membrane lipid peroxidation and characterized elevated intracellular levels Fe
Язык: Английский
Процитировано
7
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Май 27, 2024
Colorectal cancer (CRC) poses a significant global health challenge, ranking as the third most diagnosed and second leading cause of cancer-related deaths. Despite advancements in treatment, challenges such delayed diagnosis, multidrug resistance, limited therapeutic effectiveness persist, emphasizing need for innovative approaches. This review explores potential natural products, nutraceuticals, phytochemicals targeting ferroptosis-related regulators novel strategy CRC. Ferroptosis, form regulated cell death characterized by iron-dependent lethal lipid peroxide accumulation, holds substantial importance CRC progression therapy resistance. Natural known their diverse bioactive effects favorable safety profiles, emerge promising candidates to induce ferroptosis cells. Exploring amino acid, iron, metabolism regulators, oxidative stress reveals avenues inducing comprehensive provides insights into multifaceted products on proteins integral regulation, including GPX4, SLC7A11, ACSL4, NCOA4, HO-1. By elucidating intricate mechanisms through which modulate these proteins, this lays foundation
Язык: Английский
Процитировано
7
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116479 - 116479
Опубликована: Март 26, 2024
RNA methylation modifications are widespread in eukaryotes and prokaryotes, with N
Язык: Английский
Процитировано
5
Cancer Medicine, Год журнала: 2024, Номер 13(7)
Опубликована: Март 28, 2024
Abstract The N6‐methyladenosine (m6A) RNA modification has gained significant prominence as a new layer of regulatory mechanism that governs gene expression. Over the past decade, various m6A regulators responsible for introducing, eliminating, and recognising methylation have been identified. Notably, these often exhibit altered expression patterns in cancer, occasionally offering prognostic value. Nonetheless, complex roles human cancer pathology remain enigmatic, with conflicting outcomes reported different studies.In recent years, multitude inhibitors activators targeting reported. Several compounds demonstrated promising efficacy both vitro vivo models. These findings collectively underscore dynamic landscape regulation biology, revealing its potential therapeutic target indicator.
Язык: Английский
Процитировано
4
Science China Life Sciences, Год журнала: 2024, Номер 67(6), С. 1119 - 1132
Опубликована: Фев. 28, 2024
Язык: Английский
Процитировано
4
Cell Biochemistry and Function, Год журнала: 2023, Номер 41(8), С. 1488 - 1502
Опубликована: Ноя. 28, 2023
Colorectal cancer (CRC) is responsible for a significant number of cancer-related fatalities worldwide. Researchers are investigating the therapeutic potential ferroptosis, type iron-dependent controlled cell death, in context CRC. Curcumin, natural compound found turmeric, exhibits anticancer properties. This study explores effects curcumin on genes related to ferroptosis (FRGs) To gather CRC data, we used Gene Expression Profiling Interactive Analysis (GEPIA) and Omnibus (GEO) databases, while FRGs were obtained from FerrDb database PubMed. We identified 739 differentially expressed (DEGs) discovered 39 that common between DEGs. The DEGs enriched with various biological processes molecular functions, including regulation signal transduction glucose metabolism. Using Drug Interaction Database (DGIdb), predicted drugs targeting CRC-DEGs 17 drug targets. Additionally, eight essential proteins CRC, MYC, IL1B, SLC1A5. Survival analysis revealed alterations gene expression CDC25A, DDR2, FABP4, SNCA, TFAM associated prognosis patients. In SW480 human cells, treatment decreased EZH2 mRNA, simultaneously increasing SLCA5 CAV1. findings this suggest could regulate have be utilized as agent treating
Язык: Английский
Процитировано
9
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Март 13, 2024
N 6 -methyladenosine (m A) is the most abundant chemical modification in eukaryotic cells. It a post-transcriptional of mRNA, dynamic reversible process catalyzed by methyltransferase, demethylase, and binding proteins. Ferroptosis, unique iron-dependent cell death, regulated various metabolic events, including many disease-related signaling pathways. And different ferroptosis inducers or inhibitors have been identified that can induce inhibit onset through targets mechanisms. They potential clinical value treatment diverse diseases. Until now, it has shown several cancer diseases m A be involved regulation ferroptosis, which impact subsequent treatment. This paper focuses on concept, function, biological role methylation interaction between to provide new therapeutic strategies for treating malignant protecting organism targeting regulate ferroptosis.
Язык: Английский
Процитировано
3
Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 283, С. 116816 - 116816
Опубликована: Авг. 2, 2024
Fluoride exposure is widespread worldwide and poses a significant threat to organisms, particularly their gastrointestinal tracts. However, due limited knowledge of the mechanism fluoride induced intestinal injury, it has been challenging develop an effective treatment. To address this issue, we used series molecular biology in vitro vivo experiments. NaF triggered m
Язык: Английский
Процитировано
3
MedComm, Год журнала: 2024, Номер 5(9)
Опубликована: Сен. 1, 2024
Abstract N6‐methyladenosine (m6A) is the most abundant modification of RNA in eukaryotic cells. Previous studies have shown that m6A pivotal diverse diseases especially cancer. corelates with initiation, progression, resistance, invasion, and metastasis However, despite these insights, a comprehensive understanding its specific roles mechanisms within complex landscape cancer still elusive. This review begins by outlining key regulatory proteins their posttranslational modifications (PTMs), as well role chromatin accessibility transcriptional activity Additionally, it highlights impact progression modulating programmed cell death affecting tumor microenvironment through various cancer‐associated immune Furthermore, discusses how microorganisms can induce enduring epigenetic changes oncogenic effect microorganism‐associated cancers altering modifications. Last, delves into immunotherapy, encompassing therapy, checkpoint blockade, cytokine adoptive transfer direct targeting regulators. Overall, this clarifies multifaceted explores targeted therapies aimed at manipulating modification, aiming to advance research improve patient outcomes.
Язык: Английский
Процитировано
3