Epigenetic and Posttranslational Regulation of Ferroptosis DOI
Yilei Zhang,

Jingwen Xiong,

Minglin Wang

и другие.

Springer eBooks, Год журнала: 2023, Номер unknown, С. 383 - 403

Опубликована: Янв. 1, 2023

Язык: Английский

Amino acid transporters within the solute carrier superfamily: Underappreciated proteins and novel opportunities for cancer therapy DOI Creative Commons
Kiavash Hushmandi, Behzad Einollahi, Seyed Hassan Saadat

и другие.

Molecular Metabolism, Год журнала: 2024, Номер 84, С. 101952 - 101952

Опубликована: Май 3, 2024

Solute carrier (SLC), a diverse family of membrane proteins, are instrumental in orchestrating the intake and efflux nutrients including amino acids, vitamins, ions, nutrients, etc, across cell membranes. This dynamic process is critical for sustaining metabolic demands cancer cells, promoting their survival, proliferation, adaptation to tumor microenvironment. Amino acids fundamental building blocks playing essential roles not only protein synthesis but also nutrient sensing, signaling pathways that can promote tumorigenesis. As key transporters SLCs have emerged as crucial players maintaining cellular acid homeostasis, dysregulation implicated various types. Thus, understanding intricate connections between SLCs, pivotal unraveling novel therapeutic targets strategies. uptake by positively affects progression. However, some studies revealed suppressor function SLCs. Although body evaluated SLC7A11 SLC1A5, SLC proteins studied sufficiently cancer. In this review, we delve into significant impact carriers on growth progression explore current state knowledge field, shedding light molecular mechanisms underlie these relationships highlighting potential avenues future research clinical interventions. comprehensive review provides insights rapidly evolving area biology focusing one most important materials cells need, within superfamily.

Язык: Английский

Процитировано

15

Insights into the Roles of Epigenetic Modifications in Ferroptosis DOI Creative Commons

Jinghua Kong,

Hao Lyu, Qian Ouyang

и другие.

Biology, Год журнала: 2024, Номер 13(2), С. 122 - 122

Опубликована: Фев. 15, 2024

Ferroptosis is a non-apoptotic mode of cell death driven by membrane lipid peroxidation and characterized elevated intracellular levels Fe

Язык: Английский

Процитировано

7

Targeting ferroptosis regulators by natural products in colorectal cancer DOI Creative Commons
Yiping Zhang, Jun Xie

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 27, 2024

Colorectal cancer (CRC) poses a significant global health challenge, ranking as the third most diagnosed and second leading cause of cancer-related deaths. Despite advancements in treatment, challenges such delayed diagnosis, multidrug resistance, limited therapeutic effectiveness persist, emphasizing need for innovative approaches. This review explores potential natural products, nutraceuticals, phytochemicals targeting ferroptosis-related regulators novel strategy CRC. Ferroptosis, form regulated cell death characterized by iron-dependent lethal lipid peroxide accumulation, holds substantial importance CRC progression therapy resistance. Natural known their diverse bioactive effects favorable safety profiles, emerge promising candidates to induce ferroptosis cells. Exploring amino acid, iron, metabolism regulators, oxidative stress reveals avenues inducing comprehensive provides insights into multifaceted products on proteins integral regulation, including GPX4, SLC7A11, ACSL4, NCOA4, HO-1. By elucidating intricate mechanisms through which modulate these proteins, this lays foundation

Язык: Английский

Процитировано

7

Demethylases in tumors and the tumor microenvironment: Key modifiers of N6-methyladenosine methylation DOI Creative Commons

Junchen Guo,

Liang Zhao,

Meiqi Duan

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116479 - 116479

Опубликована: Март 26, 2024

RNA methylation modifications are widespread in eukaryotes and prokaryotes, with N

Язык: Английский

Процитировано

5

Targeting RNA modifications with pharmacological agents: New frontiers in cancer therapy DOI Creative Commons
Angel Guan, Justin Wong

Cancer Medicine, Год журнала: 2024, Номер 13(7)

Опубликована: Март 28, 2024

Abstract The N6‐methyladenosine (m6A) RNA modification has gained significant prominence as a new layer of regulatory mechanism that governs gene expression. Over the past decade, various m6A regulators responsible for introducing, eliminating, and recognising methylation have been identified. Notably, these often exhibit altered expression patterns in cancer, occasionally offering prognostic value. Nonetheless, complex roles human cancer pathology remain enigmatic, with conflicting outcomes reported different studies.In recent years, multitude inhibitors activators targeting reported. Several compounds demonstrated promising efficacy both vitro vivo models. These findings collectively underscore dynamic landscape regulation biology, revealing its potential therapeutic target indicator.

Язык: Английский

Процитировано

4

Ferroptosis: a critical mechanism of N6-methyladenosine modification involved in carcinogenesis and tumor progression DOI
Qingqing Wei,

Changning Xue,

Mengna Li

и другие.

Science China Life Sciences, Год журнала: 2024, Номер 67(6), С. 1119 - 1132

Опубликована: Фев. 28, 2024

Язык: Английский

Процитировано

4

Impact of curcumin on ferroptosis‐related genes in colorectal cancer: Insights from in‐silico and in‐vitro studies DOI Open Access
Ali Ahmadizad Firouzjaei, Seyed Hamid Aghaee‐Bakhtiari,

Ali Tafti

и другие.

Cell Biochemistry and Function, Год журнала: 2023, Номер 41(8), С. 1488 - 1502

Опубликована: Ноя. 28, 2023

Colorectal cancer (CRC) is responsible for a significant number of cancer-related fatalities worldwide. Researchers are investigating the therapeutic potential ferroptosis, type iron-dependent controlled cell death, in context CRC. Curcumin, natural compound found turmeric, exhibits anticancer properties. This study explores effects curcumin on genes related to ferroptosis (FRGs) To gather CRC data, we used Gene Expression Profiling Interactive Analysis (GEPIA) and Omnibus (GEO) databases, while FRGs were obtained from FerrDb database PubMed. We identified 739 differentially expressed (DEGs) discovered 39 that common between DEGs. The DEGs enriched with various biological processes molecular functions, including regulation signal transduction glucose metabolism. Using Drug Interaction Database (DGIdb), predicted drugs targeting CRC-DEGs 17 drug targets. Additionally, eight essential proteins CRC, MYC, IL1B, SLC1A5. Survival analysis revealed alterations gene expression CDC25A, DDR2, FABP4, SNCA, TFAM associated prognosis patients. In SW480 human cells, treatment decreased EZH2 mRNA, simultaneously increasing SLCA5 CAV1. findings this suggest could regulate have be utilized as agent treating

Язык: Английский

Процитировано

9

Correlation between RNA N6-methyladenosine and ferroptosis in cancer: current status and prospects DOI Creative Commons

Qianzi Liu,

Linxi Lv,

Xueding Cai

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Март 13, 2024

N 6 -methyladenosine (m A) is the most abundant chemical modification in eukaryotic cells. It a post-transcriptional of mRNA, dynamic reversible process catalyzed by methyltransferase, demethylase, and binding proteins. Ferroptosis, unique iron-dependent cell death, regulated various metabolic events, including many disease-related signaling pathways. And different ferroptosis inducers or inhibitors have been identified that can induce inhibit onset through targets mechanisms. They potential clinical value treatment diverse diseases. Until now, it has shown several cancer diseases m A be involved regulation ferroptosis, which impact subsequent treatment. This paper focuses on concept, function, biological role methylation interaction between to provide new therapeutic strategies for treating malignant protecting organism targeting regulate ferroptosis.

Язык: Английский

Процитировано

3

Fluoride exposure-induced gut microbiota alteration mediates colonic ferroptosis through N6-methyladenosine (m6A) mediated silencing of SLC7A11 DOI Creative Commons

Haonan Huang,

Yu Lin,

Jinge Xin

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 283, С. 116816 - 116816

Опубликована: Авг. 2, 2024

Fluoride exposure is widespread worldwide and poses a significant threat to organisms, particularly their gastrointestinal tracts. However, due limited knowledge of the mechanism fluoride induced intestinal injury, it has been challenging develop an effective treatment. To address this issue, we used series molecular biology in vitro vivo experiments. NaF triggered m

Язык: Английский

Процитировано

3

Role of N6‐methyladenosine RNA modification in cancer DOI Creative Commons
Yi Qu, Nannan Gao, Shengwei Zhang

и другие.

MedComm, Год журнала: 2024, Номер 5(9)

Опубликована: Сен. 1, 2024

Abstract N6‐methyladenosine (m6A) is the most abundant modification of RNA in eukaryotic cells. Previous studies have shown that m6A pivotal diverse diseases especially cancer. corelates with initiation, progression, resistance, invasion, and metastasis However, despite these insights, a comprehensive understanding its specific roles mechanisms within complex landscape cancer still elusive. This review begins by outlining key regulatory proteins their posttranslational modifications (PTMs), as well role chromatin accessibility transcriptional activity Additionally, it highlights impact progression modulating programmed cell death affecting tumor microenvironment through various cancer‐associated immune Furthermore, discusses how microorganisms can induce enduring epigenetic changes oncogenic effect microorganism‐associated cancers altering modifications. Last, delves into immunotherapy, encompassing therapy, checkpoint blockade, cytokine adoptive transfer direct targeting regulators. Overall, this clarifies multifaceted explores targeted therapies aimed at manipulating modification, aiming to advance research improve patient outcomes.

Язык: Английский

Процитировано

3