Parkinson's
disease
(PD)
is
the
second
most
common
neurodegenerative
disorder
after
Alzheimer's
disease.
Ageing
considered
to
be
greatest
risk
factor
for
PD,
with
a
complex
interplay
between
genetics
and
environment.
With
population
ageing,
prevalence
of
PD
expected
escalate
worldwide;
thus,
it
utmost
importance
reduce
burden
PD.
To
date,
there
are
no
therapies
cure
disease,
current
treatment
strategies
focus
on
management
symptoms.
Older
adults
often
have
multiple
chronic
diseases
geriatric
syndromes,
which
further
complicates
Healthcare
systems
care
models
necessary
address
broad
needs
older
patients
largely
unavailable.
In
this
New
Horizon
article,
we
discuss
various
aspects
from
an
ageing
perspective,
including
management.
We
highlight
recent
advancements
in
new
potential
improve
patient's
quality
life.
ACS Omega,
Год журнала:
2025,
Номер
10(2), С. 1864 - 1892
Опубликована: Янв. 8, 2025
Parkinson's
disease
(PD)
is
a
progressive
neurodegenerative
disorder
that
primarily
affects
movement.
It
occurs
due
to
gradual
deficit
of
dopamine-producing
brain
cells,
particularly
in
the
substantia
nigra.
The
precise
etiology
PD
not
fully
understood,
but
it
likely
involves
combination
genetic
and
environmental
factors.
therapies
available
at
present
alleviate
symptoms
do
stop
disease's
advancement.
Research
endeavors
are
currently
directed
inventing
disease-controlling
aim
inherent
mechanisms
PD.
biomarker
breakthroughs
hold
enormous
potential:
earlier
diagnosis,
better
monitoring,
targeted
treatment
based
on
individual
response
could
significantly
improve
patient
outcomes
ease
burden
this
disease.
research
an
active
evolving
field,
focusing
understanding
mechanisms,
identifying
biomarkers,
developing
new
treatments,
improving
care.
In
report,
we
explore
data
from
CAS
Content
Collection
outline
progress
We
analyze
publication
landscape
offer
perspective
into
latest
expertise
advancements.
Key
emerging
concepts
reviewed
strategies
fight
evaluated.
Pharmacological
targets,
risk
factors,
as
well
comorbid
diseases
explored,
clinical
usage
products
against
with
their
production
pipelines
trials
for
drug
repurposing
examined.
This
review
aims
comprehensive
overview
advancing
current
about
PD,
define
challenges,
assess
growth
prospects
stimulate
efforts
battling
Frontiers in Aging Neuroscience,
Год журнала:
2021,
Номер
13
Опубликована: Июнь 3, 2021
Parkinson's
disease
(PD)
is
the
most
common
neurodegenerative
movement
disorder,
and
it
characterized
by
selective
loss
of
dopaminergic
(DA)
neurons
in
substantia
nigra
pars
compacta
(SNpc),
as
well
presence
intracellular
inclusions
with
α-synuclein
main
component
surviving
DA
neurons.
Emerging
evidence
suggests
that
imbalance
proteostasis
a
key
pathogenic
factor
for
PD.
Endoplasmic
reticulum
(ER)
stress-induced
unfolded
protein
response
(UPR)
autophagy,
two
major
pathways
maintaining
proteostasis,
play
important
roles
PD
pathology
are
considered
attractive
therapeutic
targets
treatment.
However,
although
ER
stress/UPR
autophagy
appear
to
be
independent
cellular
processes,
they
closely
related
each
other.
In
this
review,
we
focused
on
molecular
cross-links
between
pathology.
We
systematically
reviewed
summarized
recent
advances
regulation
their
cross-linking
mechanisms.
also
discussed
mechanisms
coexisting
activation
dysregulated
lesion
regions
patients,
underlying
crosslinks
neurodegeneration
induced
PD-associated
genetic
factors
PD-related
neurotoxins.
Finally,
indicate
combined
would
more
effective
treatment
rather
than
regulating
one
these
conditions
alone.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(20), С. 12289 - 12289
Опубликована: Окт. 14, 2022
The
bidirectional
interaction
between
the
gut
microbiota
(GM)
and
Central
Nervous
System,
so-called
brain
axis
(GMBA),
deeply
affects
function
has
an
important
impact
on
development
of
neurodegenerative
diseases.
In
Parkinson’s
disease
(PD),
gastrointestinal
symptoms
often
precede
onset
motor
non-motor
manifestations,
alterations
in
GM
composition
accompany
pathogenesis.
Several
studies
have
been
conducted
to
unravel
role
dysbiosis
intestinal
permeability
PD
progression,
but
therapeutic
diagnostic
applications
modifying
approaches
remain
be
fully
elucidated.
After
a
brief
introduction
involvement
GMBA
disease,
we
present
evidence
for
leaky
patients.
According
these
data,
then
review
potential
GM-based
signatures
serve
as
biomarkers
highlight
emerging
probiotics,
prebiotics,
antibiotics,
dietary
interventions,
fecal
transplantation
supportive
PD.
Finally,
analyze
mutual
influence
commonly
prescribed
medications
gut-microbiota,
offer
insights
also
nasal
oral
pathology,
thus
providing
comprehensive
up-to-date
overview
microbial
features
diagnosis
treatment.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(7), С. 6354 - 6354
Опубликована: Март 28, 2023
The
term
"neurodegenerative
diseases"
(NDs)
identifies
a
group
of
heterogeneous
diseases
characterized
by
progressive
loss
selectively
vulnerable
populations
neurons,
which
progressively
deteriorates
over
time,
leading
to
neuronal
dysfunction.
Protein
aggregation
and
have
been
considered
the
most
characteristic
hallmarks
NDs,
but
growing
evidence
confirms
that
significant
dysregulation
innate
immune
pathways
plays
crucial
role
as
well.
NDs
vary
from
multiple
sclerosis,
in
autoimmune
inflammatory
component
is
predominant,
more
"classical"
such
Parkinson's
disease,
Alzheimer's
amyotrophic
lateral
spinal
muscular
atrophy.
Of
interest,
many
clinical
differences
reported
seem
be
closely
linked
sex,
may
justified
changes
mechanisms
between
affected
females
males.
In
this
review,
we
examined
some
studied
looking
at
their
pathogenic
phenotypical
features
highlight
sex-related
discrepancies,
if
any,
with
particular
interest
individuals'
responses
treatment.
We
believe
pointing
out
these
practice
help
achieve
successful
precision
personalized
care.
Archives of Toxicology,
Год журнала:
2023,
Номер
98(1), С. 95 - 119
Опубликована: Ноя. 15, 2023
Abstract
Life
expectancy
has
increased
immensely
over
the
past
decades,
bringing
new
challenges
to
health
systems
as
advanced
age
increases
predisposition
for
many
diseases.
One
of
those
is
burden
neurologic
disorders.
While
hypotheses
have
been
placed
explain
aging
mechanisms,
it
widely
accepted
that
increasing
pro-inflammatory
status
with
or
“inflammaging”
a
main
determinant
biological
aging.
Furthermore,
inflammaging
at
cornerstone
age-related
diseases
and
its
involvement
in
disorders
an
exciting
hypothesis.
Indeed,
development
elderly
seem
share
some
basic
pathways
fundamentally
converge
on
inflammation.
Peripheral
inflammation
significantly
influences
brain
function
contributes
neurological
disorders,
including
Alzheimer’s
disease,
Parkinson’s
multiple
sclerosis.
Understanding
role
pathogenesis
progressive
crucial
importance
developing
effective
treatments
interventions
can
slow
down
prevent
disease
progression,
therefore,
decreasing
social
economic
burden.
