Interaction between macrophages and ferroptosis

Cell Death and Disease, Год журнала: 2022, Номер 13(4)

Опубликована: Апрель 16, 2022

Abstract Ferroptosis, a newly discovered iron-dependent cell death pathway, is characterized by lipid peroxidation and GSH depletion mediated iron metabolism morphologically, biologically genetically different from other programmed deaths. Besides, ferroptosis usually found accompanied inflammatory reactions. So far, it has been participating in the development of many kinds diseases. Macrophages are group immune cells that widely exist our body for host defense play an important role tissue homeostasis mediating inflammation regulating iron, amino acid metabolisms through their unique functions like phagocytosis efferocytosis, cytokines secretion ROS production under polarization. According to these common points characteristics macrophages functions, it’s obvious there must be relationship between ferroptosis. Therefore, review aims at revealing interaction concerning three integrating application certain curing diseases, mostly cancer. Finally, we also provide inspirations further studies therapy some diseases targeting resident distinct tissues regulate Facts Ferroptosis considered as form its nonapoptotic hydroperoxide, metabolisms. playing crucial part various including hepatic neurological cancer, etc. phagocytic cells, existing owning such production. proved participate initiating reactions maintain balance body. Recent try treat cancer altering macrophages’ polarization which damages tumor microenvironment induces cells. Open questions How do specifically? Can use treating than cancer? What can related macrophages? Is more effective therapies when diseases?

Язык: Английский

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Identification of essential sites of lipid peroxidation in ferroptosis

Nature Chemical Biology, Год журнала: 2023, Номер 19(6), С. 719 - 730

Опубликована: Фев. 6, 2023

Язык: Английский

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Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage

Frontiers in Pharmacology, Год журнала: 2021, Номер 12

Опубликована: Март 19, 2021

Intracerebral hemorrhage (ICH) is a subtype of stroke characterized by high mortality and disability rates. To date, the exact etiology ICH-induced brain injury still unclear. Moreover, there no effective treatment to delay or prevent disease progression currently. Increasing evidence suggests that ferroptosis plays dominant role in pathogenesis ICH injury. Baicalin main active ingredient Chinese herbal medicine Scutellaria baicalensis . It has been reported exhibit neuroprotective effects against as well reduce iron deposition multiple tissues. Therefore, this study, we focused on protective mechanisms baicalin caused using hemin-induced vitro model Type IV collagenase-induced vivo model. Our results revealed enhanced cell viability suppressed rat pheochromocytoma PC12 cells treated with hemin, erastin RSL3. Importantly, showed anti-ferroptosis effect primary cortical neurons (PCN). Furthermore, alleviated motor deficits mice through inhibiting ferroptosis. Additionally, existed obvious toxicity towards liver kidney mice. Evidently, key pathological feature can development ICH. As such, potential therapeutic drug for treatment.

Язык: Английский

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Role of Ferroptosis in Stroke

Cellular and Molecular Neurobiology, Год журнала: 2022, Номер 43(1), С. 205 - 222

Опубликована: Янв. 31, 2022

Язык: Английский

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Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes

Advanced Science, Год журнала: 2023, Номер 10(24)

Опубликована: Июнь 21, 2023

Emerging evidence suggests that ferroptosis, a unique regulated cell death modality is morphologically and mechanistically different from other forms of death, plays vital role in the pathophysiological process neurodegenerative diseases, strokes. Accumulating supports ferroptosis as critical factor diseases strokes, pharmacological inhibition therapeutic target for these diseases. In this review article, core mechanisms are overviewed roles strokes described. Finally, emerging findings treating through This demonstrates by bioactive small-molecule compounds (ferroptosis inhibitors) could be effective treatments highlights potential promising avenue used to prevent article will shed light on developing novel regimens slow down progression future.

Язык: Английский

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Role and mechanism of ferroptosis in neurological diseases

Molecular Metabolism, Год журнала: 2022, Номер 61, С. 101502 - 101502

Опубликована: Апрель 19, 2022

Ferroptosis, as a new form of cell death, is different from other deaths such autophagy or senescence. Ferroptosis involves in the pathophysiological progress several diseases, including cancers, cardiovascular nervous system and kidney damage. Since oxidative stress iron deposition are broad pathological features neurological role ferroptosis diseases has been widely explored. mainly characterized by changes homeostasis, iron-dependent lipid peroxidation, glutamate toxicity accumulation, which can be specifically reversed inducers inhibitors. The regulated metabolism iron, lipids amino acids through System Xc−, voltage-dependent anion channels, p53, p62-Keap1-Nrf2, mevalonate pathways. This review also focus on regulatory pathways its research diseases. current researches mostly key ferroptosis. At same time, was found playing bidirectional regulation Therefore, specific mechanisms still need to further explored provide perspectives for application treatment

Язык: Английский

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Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury

Cell Death and Disease, Год журнала: 2022, Номер 13(5)

Опубликована: Май 30, 2022

Abstract Progressive retinal ganglion cells (RGCs) death that triggered by ischemia reperfusion (IR), leads to irreversible visual impairment and blindness, but our knowledge of post-IR neuronal related mechanisms is limited. In this study, we first demonstrated apart from necroptosis, which occurs before apoptosis, ferroptosis, characterized iron deposition lipid peroxidation, involved in the whole course IR mice. Correspondingly, all three types RGCs were found retina samples human glaucoma donors. Further, inhibitors ferroptosis (z-VAD-FMK, Necrostatin-1, Ferrostatin-1, respectively) exhibited marked RGC protection against both mice primary cultured RGCs, with Ferrostatin-1 conferring best therapeutic effect, suggesting plays a more prominent role process death. We also activated microglia, Müller cells, immune responses, intracellular reactive oxygen species accumulation following significantly mitigated after each inhibitor treatment, albeit varying degrees. Moreover, combination z-VAD-FMK Necrostatin-1 prevented IR-induced better than any alone. These findings stand advance cascade guide future therapy for protection.

Язык: Английский

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GPX4, ferroptosis, and diseases

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116512 - 116512

Опубликована: Апрель 3, 2024

GPX4 (Glutathione peroxidase 4) serves as a crucial intracellular regulatory factor, participating in various physiological processes and playing significant role maintaining the redox homeostasis within body. Ferroptosis, form of iron-dependent non-apoptotic cell death, has gained considerable attention recent years due to its involvement multiple pathological processes. is closely associated with ferroptosis functions primary inhibitor this process. Together, contribute pathophysiology several diseases, including sepsis, nervous system ischemia reperfusion injury, cardiovascular cancer. This review comprehensively explores roles impacts development progression these aim providing insights for identifying potential therapeutic strategies future.

Язык: Английский

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Ferroptosis in life: To be or not to be

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 159, С. 114241 - 114241

Опубликована: Янв. 10, 2023

Ferroptosis is a novel type of programmed cell death, characterized by dysregulated iron metabolism and accumulation lipid peroxides. It features the alteration mitochondria aberrant excessive as well loss cysteine-glutathione-GPX4 axis. Eventually, accumulated peroxides result in lethal damage to cells. induced overloading ROS can be inhibited activation GPX4 pathway, FS1-CoQ10 GCH1-BH4 DHODH it also regulated oncogenes tumor suppressors. involves various physiological pathological processes, increasing evidence indicates that ferroptosis play critical role cancers other diseases. inhibits proliferation malignant cells types inducing may become new method cancer treatment. Many inhibitors targeting key factors such SLC7A11, GPX4, overload have been developed. The application mainly divided into two directions, i.e. avoid healthy selectively induce cancers. In this review, we provide analysis concept, regulation pathways explored its roles diseases, summarized compounds ferroptosis, aiming promote speed clinical use induction

Язык: Английский

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Iron homeostasis imbalance and ferroptosis in brain diseases

MedComm, Год журнала: 2023, Номер 4(4)

Опубликована: Июнь 26, 2023

Brain iron homeostasis is maintained through the normal function of blood-brain barrier and regulation at systemic cellular levels, which fundamental to brain function. Excess can catalyze generation free radicals Fenton reactions due its dual redox state, thus causing oxidative stress. Numerous evidence has indicated diseases, especially stroke neurodegenerative are closely related mechanism imbalance in brain. For one thing, diseases promote accumulation. another, accumulation amplifies damage nervous system exacerbates patients' outcomes. In addition, triggers ferroptosis, a newly discovered iron-dependent type programmed cell death, neurodegeneration received wide attention recent years. this context, we outline metabolism focus on current stroke, Alzheimer's disease, Parkinson's disease. Meanwhile, also discuss ferroptosis simultaneously enumerate drugs for chelators inhibitors.

Язык: Английский

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