Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
Год журнала:
2025,
Номер
unknown, С. 167791 - 167791
Опубликована: Март 1, 2025
Kidney
stones
represent
a
highly
prevalent
urological
disorder
worldwide,
with
high
incidence
and
recurrence
rates.
Calcium
oxalate
(CaOx)
crystal-induced
kidney
injury
serves
as
the
foundational
mechanism
for
formation
progression
of
CaOx
stones.
Regulated
cell
death
(RCD)
such
ferroptosis,
necroptosis,
pyroptosis
are
essential
in
pathophysiological
process
injury.
Ferroptosis,
newly
discovered
RCD,
is
characterized
by
its
reliance
on
iron-mediated
lipid
peroxidation.
Necroptosis,
widely
studied
programmed
necrosis,
initiates
necrotic
phenotype
that
resembles
apoptosis
appearance.
Pyroptosis,
type
RCD
involves
gasdermin
protein,
accompanied
inflammation
immune
response.
In
recent
years,
increasing
amounts
evidence
has
demonstrated
significant
processes
involved
Herein,
we
summed
up
roles
Furthermore,
delved
into
curative
potential
targeting
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1109 - 1109
Опубликована: Сен. 13, 2024
Oxidative
stress
is
the
result
of
imbalance
between
reactive
oxygen
and
nitrogen
species
(RONS),
which
are
produced
by
several
endogenous
exogenous
processes,
antioxidant
defenses
consisting
molecules
that
protect
biological
systems
from
free
radical
toxicity.
a
major
factor
in
aging
process,
contributing
to
accumulation
cellular
damage
over
time.
biomolecules,
leads
DNA
alterations,
lipid
peroxidation,
protein
oxidation,
mitochondrial
dysfunction
resulting
senescence,
immune
system
tissue
dysfunctions,
increased
susceptibility
age-related
pathologies,
such
as
inflammatory
disorders,
cardiovascular
neurodegenerative
diseases,
diabetes,
cancer.
stress-driven
mutations,
or
methylation
histone
modification,
alter
gene
expression,
key
determinants
tumor
initiation,
angiogenesis,
metastasis,
therapy
resistance.
Accumulation
genetic
epigenetic
damage,
oxidative
contributes,
eventually
unrestrained
cell
proliferation,
inhibition
differentiation,
evasion
death,
providing
favorable
conditions
for
tumorigenesis.
Colorectal,
breast,
lung,
prostate,
skin
cancers
most
frequent
aging-associated
malignancies,
implicated
their
pathogenesis
behavior.
Our
aim
shed
light
on
molecular
mechanisms
link
stress,
aging,
cancers,
highlighting
impact
both
RONS
antioxidants,
provided
diet
exercise,
immunity,
development
an
antitumor
response.
The
dual
role
ROS
physiological
regulators
signaling
responsible
well
its
use
anti-tumor
therapeutic
purposes,
will
also
be
discussed.
Managing
crucial
promoting
healthy
reducing
risk
tumors.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 3, 2025
Early
missed
abortion
is
defined
as
a
pregnancy
of
≤
12
weeks
in
which
there
cessation
life
the
developing
embryo
or
fetus,
leading
to
its
retention
within
uterine
cavity
without
being
spontaneously
expelled
promptly.
This
condition
commonly
observed
and
significantly
impacts
human
reproductive
health.
study
aimed
identify
key
genes
related
ferroptosis
that
could
serve
novel
biomarkers
for
early
abortion.
Findings
from
gene
ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
analyses
indicate
correlation
between
iron-
DEFRGS
modules
p53
signaling,
mitophagy-animal,
protein
digestion
absorption
pathways.
An
analysis
protein-protein
interaction
(PPI)
network
was
conducted
on
DEFRGs,
identifying
five
central
(TP53,
EZH2,
TIMP1,
SLC3A2,
GABARAPL2)
using
STRING
Cytohubba
ROC
curves.
The
expression
pivotal
both
missed-abortion
control
groups
verified
by
RT-qPCR.
CIBERSORT
revealed
notable
increase
infiltration
levels
CD8
+
T
lymphocytes
M2
macrophages
among
individuals
group.
Additionally,
ceRNA
constructed
predict
interactions
mRNA,
miRNA,
lncRNA
genes.
However,
interacting
miRNAs
predicted
SLC3A2
miRanda,
miRDB,
TargetScan
databases
were
limited
hsa-miR-661
hsa-miR-4311,
with
no
lncRNAs
found
spongeScan
database.
research
has
identified
be
targeted
detection
management
abortions.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8423 - 8423
Опубликована: Авг. 1, 2024
The
most
abundant
tripeptide—glutathione
(GSH)—and
the
major
GSH-related
enzymes—glutathione
peroxidases
(GPxs)
and
glutathione
S-transferases
(GSTs)—are
highly
significant
in
regulation
of
tumor
cell
viability,
initiation
development,
its
progression,
drug
resistance.
high
level
GSH
synthesis
different
cancer
types
depends
not
only
on
increasing
expression
key
enzymes
γ-glutamyl
cycle
but
also
changes
transport
velocity
precursor
amino
acids.
ability
GPxs
to
reduce
hydroperoxides
is
used
for
cellular
each
member
GPx
family
has
a
mechanism
action
site
maintaining
redox
balance.
GSTs
catalyze
conjugation
electrophilic
substances
reduction
organic
take
part
signaling
pathways.
By
catalyzing
S-glutathionylation
target
proteins,
are
involved
processes,
including
metabolism
(e.g.,
glycolysis
PPP),
signal
transduction,
transcription
regulation,
development
resistance
anticancer
drugs.
In
this
review,
recent
findings
synthesis,
roles
functions
GPxs,
GST
isoforms
discussed,
along
with
search
inhibitors
treatment.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Авг. 12, 2024
Ferroptosis
is
an
iron-dependent
form
of
cell
death
that
results
from
excess
lipid
peroxidation
in
cellular
membranes.
Within
the
last
decade,
physiological
and
pathological
roles
for
ferroptosis
have
been
uncovered
autoimmune
diseases,
inflammatory
conditions,
infection,
cancer
biology.
Excitingly,
metabolism
may
be
targeted
to
induce
by
cancers
are
resistant
other
forms
death.
sensitivity
regulated
oxidative
stress,
metabolism,
iron
which
all
influenced
tumor
microenvironment
(TME).
Whereas
some
types
shown
adapt
these
stressors,
it
not
clear
how
immune
cells
regulate
their
sensitivities
ferroptosis.
In
this
review,
we
discuss
mechanisms
different
subsets,
influences
infiltrate
TME,
interactions
can
determine
epithelial-to-mesenchymal
transition
(EMT)
metastasis.
While
much
focus
has
placed
on
inducing
cells,
important
considerations
ferroptosis-modulating
strategies
impact
anti-tumor
immunity.
From
perspective,
also
promising
immunotherapies
field
challenges
associated
with
targeting
specific
populations.
Biology,
Год журнала:
2025,
Номер
14(1), С. 61 - 61
Опубликована: Янв. 13, 2025
miRNAs
are
small
non-coding
RNA
molecules
that
play
critical
roles
in
the
regulation
of
gene
expression
and
have
been
closely
associated
with
various
diseases,
including
cancer.
These
significantly
influence
cell
cycle
tumor
cells
control
programmed
death
(apoptosis).
Currently,
research
on
has
become
a
major
focus
developing
cancer
therapies.
Osteosarcoma,
malignant
neoplasm
predominantly
occurring
during
adolescence
later
life,
is
characterized
by
high
propensity
for
metastasis.
This
review
explores
role
initiation
progression
cancer,
highlighting
their
potential
as
predictive
biomarkers
disease.
It
discusses
mechanisms
which
natural
products
modulate
miRNA
activity
to
apoptosis,
ferroptosis,
autophagy
osteosarcoma
cells,
aiming
identify
new
strategies
treatment.
Recent
studies
how
regulate
reduce
resistance
chemotherapy
also
reviewed.
Furthermore,
elaborates
m6A
modifications
expression,
thereby
exerting
antitumor
effects.
In
this
process,
interactions
between
identified,
both
jointly
influencing
tumorigenesis
progression,
offering
perspective
approaches
could
help
uncover
novel
regulatory
pathways
provide
theoretical
foundation
drugs
identifying
therapeutic
targets.
