Cyborg and Bionic Systems,
Год журнала:
2024,
Номер
5
Опубликована: Янв. 1, 2024
Depression
is
a
common
and
severely
debilitating
neuropsychiatric
disorder.
Multiple
studies
indicate
strong
correlation
between
the
occurrence
of
immunological
inflammation
presence
depression.
The
basolateral
amygdala
(BLA)
crucial
in
cognitive
physiological
processing
control
emotion.
However,
due
to
lack
detection
tools,
neural
activity
BLA
during
depression
not
well
understood.
In
this
study,
microelectrode
array
(MEA)
based
on
shape
anatomical
location
brain
was
designed
manufactured.
Rats
were
injected
with
lipopolysaccharide
(LPS)
for
7
consecutive
days
induce
depressive
behavior.
We
used
MEA
detect
before
modeling,
after
LPS
administration
days.
results
showed
that
treatment,
spike
firing
neurons
region
rats
gradually
became
more
intense,
local
field
potential
power
also
increased
progressively.
Further
analysis
revealed
administration,
predominantly
theta
rhythm,
obvious
periodic
characteristics
appearing
d
relative
band
significantly
increased.
summary,
our
suggest
enhanced
related
state
rats,
providing
valuable
guidance
research
into
mechanisms
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9695 - 9695
Опубликована: Сен. 7, 2024
The
research
in
neuroimmunomodulation
aims
to
shed
light
on
the
complex
relationships
that
exist
between
immune
and
neurological
systems
how
they
affect
human
body.
This
multidisciplinary
field
focuses
way
responses
are
influenced
by
brain
activity
neural
function
is
impacted
immunological
signaling.
provides
important
insights
into
a
range
of
medical
disorders.
Targeting
both
pathways,
neuroimmunomodulatory
approaches
used
clinical
pain
management
address
chronic
pain.
Pharmacological
therapies
aim
modulate
neuroimmune
interactions
reduce
inflammation.
Furthermore,
bioelectronic
techniques
like
vagus
nerve
stimulation
offer
non-invasive
control
these
systems,
while
neuromodulation
transcranial
magnetic
modify
neuronal
Within
context
aging,
analyzes
ways
which
alterations
brought
aging
contribute
cognitive
decline
neurodegenerative
illnesses.
Restoring
homeostasis
through
strategies
shows
promise
reducing
age-related
decline.
Research
mood
disorders
dysregulation
relates
illnesses
including
anxiety
depression.
Immune
system
fluctuations
increasingly
recognized
for
their
impact
function,
leading
novel
treatments
target
interactions.
review
emphasizes
interdisciplinary
cooperation
continuous
necessary
better
understand
relationship
systems.
World Journal of Psychiatry,
Год журнала:
2022,
Номер
12(5), С. 722 - 738
Опубликована: Май 13, 2022
Depression
is
the
most
common
type
of
depressive
disorder.
The
sleep
disorder
associated
with
depression
insomnia.
Insomnia
and
are
closely
related.To
investigate
relationship
designed
questionnaire
items
depression,
analyze
related
factors
depression.Questionnaire
included
Patient
Health
Questionnaire-9
(PHQ-9)
Pittsburgh
quality
index
(PSQI),
12
kinds
diseases,
8
general
characteristics,
20
insomnia
totally
56
were
filled
out
by
411
patients
enrolled.All
9
PHQ-9,
6
components
PSQI
(except
duration),
education,
living
situation,
exercise,
years
insomnia,
western
medicine
treatment,
Chinese
psychotherapy,
treatment
expected
to
treat
psychological
counseling,
habit
1
h
before
bed,
lunch
break,
diagnosed
coronary
heart
disease,
mental
illness
showed
significant
difference
between
without
group.
By
univariate
analysis
multivariate
analysis.
odds
ratio
disease
(P
=
0.01)
difference.
Their
ratios
0.71
(0.55,
0.93),
2.09
(1.32,
3.31),
0.76
(0.63,
0.91),
0.89
(0.81,
0.98),
0.32
(0.17,
0.60),
0.43
(0.23,
0.79).We
demonstrated
that
affect
depression.
PLoS ONE,
Год журнала:
2022,
Номер
17(2), С. e0264404 - e0264404
Опубликована: Фев. 25, 2022
Background
Many
studies
have
predicted
major
depressive
disorder
(MDD)
as
the
leading
cause
of
global
health
by
2030
due
to
its
high
prevalence,
disability,
and
illness.
However,
actual
pathophysiological
mechanism
behind
depression
is
unknown.
Scientists
consider
alterations
in
cytokines
might
be
tools
for
understanding
pathogenesis
treatment
MDD.
Several
past
on
several
inflammatory
cytokine
expressions
MDD
reveal
that
an
process
activated,
although
precise
causes
changes
levels
are
unclear.
Therefore,
we
aimed
investigate
resistin
G-CSF
patients
controls
explore
their
role
development
depression.
Methods
We
included
220
participants
this
study.
Among
them,
108
112
age-sex
matched
healthy
control
(HCs).
used
DSM-5
evaluate
study
participants.
Also,
applied
Ham-D
rating
scale
assess
severity
patients.
Serum
were
measured
using
ELISA
kits
(BosterBio,
USA).
Results
The
present
observed
increased
serum
compared
HCs
(13.82
±
1.24ng/mL
6.35
0.51ng/mL,
p
<0.001).
did
not
find
such
between
groups.
scores
showed
a
significant
correlation
with
but
patient
group.
Furthermore,
ROC
analysis
fairly
predictive
performance
(AUC
=
0.746).
Conclusion
findings
suggest
higher
associated
pathophysiology
This
elevated
level
may
serve
early
risk
assessment
indicator
still
unclear
despite
neuroprotective
anti-inflammatory
effects.
Psychiatry and Clinical Neurosciences,
Год журнала:
2023,
Номер
77(5), С. 252 - 263
Опубликована: Янв. 15, 2023
A
third
of
people
suffering
from
major
depressive
disorder
do
not
experience
a
significant
improvement
in
their
symptoms
even
after
adequate
treatment
with
two
different
antidepressant
medications.
This
common
condition,
termed
treatment-resistant
depression
(TRD),
severely
affects
the
quality
life
millions
worldwide,
causing
long-lasting
interpersonal
problems
and
social
costs.
Given
its
epidemiological
clinical
relevance
little
consensus
on
whether
neurobiological
underpinnings
TRD
differ
treatment-sensitive
(TSD),
we
sought
to
highlight
convergent
morphometric
functional
neuroimaging
correlates
TRD.
Cyborg and Bionic Systems,
Год журнала:
2024,
Номер
5
Опубликована: Янв. 1, 2024
Depression
is
a
common
and
severely
debilitating
neuropsychiatric
disorder.
Multiple
studies
indicate
strong
correlation
between
the
occurrence
of
immunological
inflammation
presence
depression.
The
basolateral
amygdala
(BLA)
crucial
in
cognitive
physiological
processing
control
emotion.
However,
due
to
lack
detection
tools,
neural
activity
BLA
during
depression
not
well
understood.
In
this
study,
microelectrode
array
(MEA)
based
on
shape
anatomical
location
brain
was
designed
manufactured.
Rats
were
injected
with
lipopolysaccharide
(LPS)
for
7
consecutive
days
induce
depressive
behavior.
We
used
MEA
detect
before
modeling,
after
LPS
administration
days.
results
showed
that
treatment,
spike
firing
neurons
region
rats
gradually
became
more
intense,
local
field
potential
power
also
increased
progressively.
Further
analysis
revealed
administration,
predominantly
theta
rhythm,
obvious
periodic
characteristics
appearing
d
relative
band
significantly
increased.
summary,
our
suggest
enhanced
related
state
rats,
providing
valuable
guidance
research
into
mechanisms
