Electrical stimulation for therapeutic approach

Deleted Journal, Год журнала: 2023, Номер 1(2)

Опубликована: Апрель 1, 2023

Abstract Electrical stimulation as a therapeutic approach is widely applicable in terms of target tissues or effects. This method can be an alternative to conventional therapies for patients who are resistant drugs ineligible surgical operations. In addition, researchers have actively studied how adjust the parameters electrical order improve effectiveness, many already received treatments with stimulation. With respect devices stimulation, recent studies focused on developing reliability safe and long‐term From point view engineers, comprehensive understanding modulates biological system essential develop advanced strategies that provide effective results. Herein, fundamental mechanisms delivering reviewed along requirements need qualified by electrodes. Furthermore, latest advances discussed followed introduction representative applications

Язык: Английский

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Anti-neuroinflammatory agent rhein lysinate-based self-assembled injectable hydrogel loaded with ZL006 for promoting post-stroke functional recovery

Biomaterials, Год журнала: 2025, Номер unknown, С. 123124 - 123124

Опубликована: Янв. 1, 2025

Язык: Английский

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A Bibliometric Analysis of the Application of Brain-Computer Interface in Rehabilitation Medicine Over the Past 20 Years

Journal of Multidisciplinary Healthcare, Год журнала: 2025, Номер Volume 18, С. 1297 - 1317

Опубликована: Март 1, 2025

This study aims to conduct a bibliometric analysis of the application brain- computer interface (BCI) in rehabilitation medicine, assessing current state, developmental trends, and future potential this field. By systematically analyzing relevant literature, we seek identify key research themes enhance understanding BCI technology rehabilitation. We utilized tools such as VOSviewer CiteSpace screen analyze 426 articles from Web Science Core Collection (WoSCC) database. quantitatively evaluated citation patterns, publication collaboration networks institutions authors uncover hotspots frontier dynamics The findings indicate continuous increase publications since 2003, with notable peak occurring between 2019 2021. revealed that motor imagery, recovery, signal processing are predominant themes. Furthermore, United States China leading volume related medicine. Key include University Tübingen New York State Department Health, significant contributions scholars like Niels Birbaumer. Although on medicine shows efficacy, further exploration certain directions is needed, along promotion interdisciplinary comprehensively address complex real-world issues function impairment. Future should focus optimizing training models, enhancing technical feasibility, exploring home applications facilitate broader adoption

Язык: Английский

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3D printing of functional bioengineered constructs for neural regeneration: a review

International Journal of Extreme Manufacturing, Год журнала: 2023, Номер 5(4), С. 042004 - 042004

Опубликована: Июль 7, 2023

Highlights Various 3D printing techniques for neural tissue-engineered scaffolds or living cell-laden constructs are summarized and compared. Strategies by integrating topographical, biochemical electroactive cues inside 3D-printed functional regeneration were introduced. The typical applications of bioengineered demonstrated. challenges future outlook associated with in various categories discussed.

Язык: Английский

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Conductive nerve conduit with piezoelectric properties for enhanced PC12 differentiation

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Июль 25, 2023

Restoration of nerve tissue remains highly challenging, mainly due to the limited regeneration capacity nervous system and development fibrosis. This limitation necessitates designing new guidance channel promote repairing. In this study, we developed a novel core/shell conduit induce PC12 differentiation. Co-electrospinning method was utilized produce fibrous shell containing polycaprolactone/polyvinylidene fluoride PCL/PVDF, gelatin polyaniline/graphene (PAG) nanocomposite. The core section filled with chitosan-gelatin hydrogel PAG ZnO nanoparticles. Such shows antibacterial activity, electrical conductivity piezoelectric property. effect such engineered on differentiation investigated by analyzing markers Nestin microtubule-associated protein 2 (MAP2) through immunocytochemistry PCR-RT techniques. result revealed that could significantly MAP2 gene expression in cells and, thus, it is viable option for effective cell regeneration.

Язык: Английский

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Functional-oriented, portable brain–computer interface training for hand motor recovery after stroke: a randomized controlled study

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Май 11, 2023

Brain-computer interfaces (BCIs) have been proven to be effective for hand motor recovery after stroke. Facing kinds of dysfunction the paretic hand, task BCIs rehabilitation is relatively single, and operation many BCI devices complex clinical use. Therefore, we proposed a functional-oriented, portable equipment explored efficiency stroke.Stroke patients were randomly assigned group control group. The received BCI-based grasp/open training, while task-oriented guidance training. Both groups 20 sessions training in 4 weeks, each session lasted 30 min. Fugl-Meyer assessment upper limb (FMA-UE) was applied outcomes, EEG signals obtained processing.The progress FMA-UE between [10.50 (5.75, 16.50)] [5.00 (4.00, 8.00)] significantly different (Z = -2.834, P 0.005). Meanwhile, both improved (P < 0.001). A total 24 achieved minimal clinically important difference (MCID) with an rate 80%, 16 MCID, 51.6%. lateral index open decreased -2.704, 0.007). average accuracy stroke 70.7%, which by 5.0% final compared first session.Targeted movement two modes, namely grasp open, design may suitable dysfunction. can promote stroke, it expected widely used practice. change inter-hemispheric balance mechanism recovery.ChiCTR2100044492.

Язык: Английский

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tVNS in Stroke: A Narrative Review on the Current State and the Future

Stroke, Год журнала: 2023, Номер 54(10), С. 2676 - 2687

Опубликована: Авг. 30, 2023

Ischemic stroke is a leading cause of disability and there paucity therapeutic strategies that promote functional recovery after stroke. Transcutaneous vagus nerve stimulation (tVNS) has shown promising evidence as tool to reduce infarct size in animal models hyperacute In chronic stroke, tVNS paired with limb movements been enhance neurological recovery. this review, we summarize the current for preclinical clinical trials humans. We highlight mechanistic pathways involved beneficial effects tVNS. critically evaluate gaps knowledge recommend key areas research required translate into practice acute

Язык: Английский

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Harnessing the uninjured hemisphere for treatment of the stroke or brain-injured patient – evolution of the contralateral C7 transfer

Journal of Hand Surgery (European Volume), Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

This article presents a comprehensive review of contralateral C7 (cC7) transfer surgery, tracing its evolution from treating brachial plexus injuries to ipsilateral surgery in upper motor neurone injuries. The cC7 was initially postulated restore function by replacing injured nerves at the peripheral level, but dynamic cortical reorganization has since been demonstrated post-surgery, which potentially allows harnessing procedure expand span control uninjured hemisphere conditions like hemiplegic stroke. By integrating principles nerve regeneration and brain plasticity through phased rehabilitation programmes, published clinical results have significant improvements limb function, confirming procedure’s safety efficacy, with donor site morbidity that is typically mild transient. may play major role future restoring patients who suffered lesions.

Язык: Английский

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Chinese herbal medicine for the treatment of children with cerebral palsy: a meta-analysis of randomized controlled trials with core herbs exploration

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 26, 2025

Chinese herbal medicine (CHM) taken orally is frequently utilized to enhance functional ability and independence in cerebral palsy (CP); nonetheless, there a lack of current evidence regarding the efficacy oral CHM treating CP. Additionally, general complexities prescriptions often obscure underlying mechanisms. Our study aims assess CP, meta-analysis will be conducted on randomized clinical trials (RCTs). We searched Cochrane Library, PubMed, Embase, Scopus, PubMed Central, ClinicalTrials.gov, China National Knowledge Infrastructure (CNKI), from 1990 2022. The primary outcome was improvement Effectiveness rate (ER). secondary motor function (GMFM). Subgroup analysis trial sequential (TSA) were confirm results consistency. Core CHMs investigated through system pharmacology analysis. Seventeen RCTs analyzed, which with Standard treatment (ST) compared ST alone. All participants aged <11 years. More group achieved prominent ER (RR: 1.21, 95% CI: 1.13-1.30, p-value < 0.001, I2 = 32%) higher GMFM (SMD: 1.49; 1.33-1.65, 92%). TSA also showed similar proper statistical power. CHMs, such as Glycyrrhiza uralensis Fisch. Ex DC., Poria cocos (Schw.) Wolf, Paeonia lactiflora Pall., processed Rehmannia glutinosa (Gaertn.) Astragalus mongholicus Bunge, Angelica sinensis (Oliv.) Diels, exerted effects immune modulation metabolism systems. subgroup using core or longer duration, studies enrolling CP spastic mixed type, mild-to-moderate severity had better outcomes groups less heterogeneity. may have positive impact managing pediatric CP; however, potential bias design should improved. Identifier CRD42023424754.

Язык: Английский

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Effect of robot-assisted training for lower limb rehabilitation on lower limb function in stroke patients: a systematic review and meta-analysis

Frontiers in Human Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Март 5, 2025

The effectiveness of lower extremity rehabilitation robots in rehabilitating stroke patients is still controversial. With this systematic review, the aim to analyze whether assisted training limb robot more effective promoting function compared with traditional physical therapy. We conducted a thorough search nine databases for relevant randomized controlled trials published between time their construction and February 2024. Cochrane Collaboration tool was used assess risk bias each included literature, meta-analyses subgroup analyses were carried out Revman 5.4 software. This study followed PRIMA reporting statement provided by EQUATOR. meta-analysis includes 12 articles 651 patients. Lower robot-assisted significantly improved motor function, walking ability, ability balance However, effect on gait coordination not statistically significant. Robot-assisted may considerably enhance capacity, while also providing novel option recuperate. http://www.crd.york.ac.uk/prospero/#recordDetails, identifier CRD-42024504930.

Язык: Английский

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