Bioengineering,
Год журнала:
2022,
Номер
9(10), С. 526 - 526
Опубликована: Окт. 6, 2022
The
purpose
of
this
study
was
to
clarify
the
role
saturated
fats
from
cocoa
butter
(plant
source)
compared
with
lard
(animal
on
alcoholic
liver
damage
in
rats.
Male
Wistar
rats
were
fed
either
a
control
diet
(C)
or
an
ethanol
(E),
and
dietary
(corn
oil,
olive
safflower
oil)
these
two
diets
further
replaced
by
(CL,
EL)
(CC,
EC).
After
8-week
feeding,
plasma
aspartate
aminotransferase
(AST)
alanine
(ALT)
activities,
hepatic
triglyceride
(TG)
levels,
intercellular
adhesion
molecular
(ICAM)-1
cytochrome
P450
2E1
(CYP2E1)
protein
expression,
interleukin
(IL)-1β
significantly
increased
E
group
C
group.
In
addition,
histopathological
scores
fatty
changes,
inflammatory
cell
infiltration,
degeneration
necrosis
higher
those
However,
changes
inhibited
only
EC
as
well
degeneration,
being
lower
EL
groups.
Plasma
ICAM-1
tumor
factor
(TNF)-α,
IL-1β,
IL-6,
IL-10
levels
groups
than
Moreover,
correlation
analysis
showed
that
positively
correlated
erythrocytic
oleic
acid
(C18:1)
negatively
linoleic
(C18:2).
conclusion,
protected
against
lipid
accumulation
inflammation
chronically
ethanol.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 26, 2025
Background
The
QingGan
LiDan
capsule
(QGLD)
consists
of
five
traditional
Chinese
herbs,
which
have
been
used
for
hepatobiliary
diseases
such
as
jaundice.
However,
the
effects
and
mechanisms
by
QGLD
prevent
alcoholic
liver
(ALD)
remain
unknown.
Aim
study
Investigate
therapeutic
potential
Lidan
in
alleviating
alcohol-induced
injury.
Materials
Methods
Acute
injury
model
chronic
Binge
ethanol
Feeding
Model
(NIAAA)
were
established.
Mice
administered
(360,
720,
1,440
mg/kg)
or
vehicle.
Liver
function
indicators
(ALT,
AST),
serum
lipid
(TC,
TG),
antioxidant
markers
(SOD,
GSH,
MDA),
metabolism/transport
genes
relative
expression
levels,
ileal
villus
morphology
analyzed.
Network
pharmacology
analysis
was
also
performed
to
identify
targets
pathways
QGLD.
Results
reduced
ALT,
AST,
hepatic
TC,
TG,
droplet
accumulation
both
models.
It
upregulated
enzymes
GSH)
downregulated
MDA.
regulated
mRNA
levels
related
NRF2/KEAP1
pathway
transport.
identified
221
targets.
Conclusion
mitigates
reducing
accumulation,
regulating
transport
enhancing
capacity.
This
supports
its
application
ALD
management.
Hepatology Communications,
Год журнала:
2023,
Номер
7(7)
Опубликована: Июнь 28, 2023
Fatty
liver
diseases,
including
alcohol-associated
disease
(ALD)
and
nonalcoholic
fatty
(NAFLD),
affect
a
large
number
of
people
worldwide
become
one
the
major
causes
end-stage
disease,
such
as
cirrhosis
hepatocellular
carcinoma
(HCC).
Unfortunately,
there
are
currently
no
approved
pharmacological
treatments
for
ALD
or
NAFLD.
This
situation
highlights
urgent
need
to
explore
new
intervention
targets
discover
effective
therapeutics
The
lack
properly
validated
preclinical
models
is
obstacle
development
clinical
therapies.
NAFLD
have
been
in
decades,
but
still
that
recapitulate
full
spectrum
Throughout
this
review,
we
summarize
current
vitro
vivo
used
research
on
diseases
discuss
advantages
limitations
these
models.
