Bioengineering,
Год журнала:
2022,
Номер
9(10), С. 526 - 526
Опубликована: Окт. 6, 2022
The
purpose
of
this
study
was
to
clarify
the
role
saturated
fats
from
cocoa
butter
(plant
source)
compared
with
lard
(animal
on
alcoholic
liver
damage
in
rats.
Male
Wistar
rats
were
fed
either
a
control
diet
(C)
or
an
ethanol
(E),
and
dietary
(corn
oil,
olive
safflower
oil)
these
two
diets
further
replaced
by
(CL,
EL)
(CC,
EC).
After
8-week
feeding,
plasma
aspartate
aminotransferase
(AST)
alanine
(ALT)
activities,
hepatic
triglyceride
(TG)
levels,
intercellular
adhesion
molecular
(ICAM)-1
cytochrome
P450
2E1
(CYP2E1)
protein
expression,
interleukin
(IL)-1β
significantly
increased
E
group
C
group.
In
addition,
histopathological
scores
fatty
changes,
inflammatory
cell
infiltration,
degeneration
necrosis
higher
those
However,
changes
inhibited
only
EC
as
well
degeneration,
being
lower
EL
groups.
Plasma
ICAM-1
tumor
factor
(TNF)-α,
IL-1β,
IL-6,
IL-10
levels
groups
than
Moreover,
correlation
analysis
showed
that
positively
correlated
erythrocytic
oleic
acid
(C18:1)
negatively
linoleic
(C18:2).
conclusion,
protected
against
lipid
accumulation
inflammation
chronically
ethanol.
Employing
network
pharmacology
and
molecular
docking,
the
study
predicts
active
compounds
in
garlic
elucidates
their
mechanism
inhibiting
development
of
alcoholic
liver
disease
(ALD).
ALD
is
a
global
chronic
with
potential
for
hepatocellular
carcinoma
progression.
Applied Sciences,
Год журнала:
2023,
Номер
13(8), С. 5112 - 5112
Опубликована: Апрель 20, 2023
Acute
alcoholic
liver
injury
is
an
important
health
problem
worldwide.
Apples
are
rich
in
many
nutrients
and
have
a
variety
of
biological
activities,
including
antioxidant,
anti-inflammatory,
anti-tumor,
therefore
the
potential
to
be
natural
protective
agent
against
acute
injury.
This
study
evaluated
effect
apples
(Malus
pumila
Mill)
on
rats.
Male
Wistar
rats
were
randomly
assigned
four
groups:
control
group
(C),
that
was
fed
fresh
(CA),
ethanol-treated
(E),
(EA).
Rats
treated
with
continuous
forced
gavage
40°
ethanol
(4
mL/kg)
for
one
week
simulate
human
alcoholism.
Liver
assessed
based
changes
serum
levels
alanine
aminotransferase
(ALT)
aspartate
(AST),
as
well
histological
analysis.
The
terms
alcohol
metabolism,
oxidative
stress,
inflammation,
lipid
synthesis,
tissue
fibrosis.
results
showed
apple
consumption
protected
injury,
indicated
by
decreased
ALT
AST
levels,
reduced
peroxidation,
improved
histopathology.
Moreover,
increased
antioxidant
enzyme
activity
inflammatory
cytokine
liver.
These
findings
suggest
may
ethanol-induced
rats,
possibly
through
its
anti-inflammatory
properties.
Bioengineering,
Год журнала:
2022,
Номер
9(10), С. 526 - 526
Опубликована: Окт. 6, 2022
The
purpose
of
this
study
was
to
clarify
the
role
saturated
fats
from
cocoa
butter
(plant
source)
compared
with
lard
(animal
on
alcoholic
liver
damage
in
rats.
Male
Wistar
rats
were
fed
either
a
control
diet
(C)
or
an
ethanol
(E),
and
dietary
(corn
oil,
olive
safflower
oil)
these
two
diets
further
replaced
by
(CL,
EL)
(CC,
EC).
After
8-week
feeding,
plasma
aspartate
aminotransferase
(AST)
alanine
(ALT)
activities,
hepatic
triglyceride
(TG)
levels,
intercellular
adhesion
molecular
(ICAM)-1
cytochrome
P450
2E1
(CYP2E1)
protein
expression,
interleukin
(IL)-1β
significantly
increased
E
group
C
group.
In
addition,
histopathological
scores
fatty
changes,
inflammatory
cell
infiltration,
degeneration
necrosis
higher
those
However,
changes
inhibited
only
EC
as
well
degeneration,
being
lower
EL
groups.
Plasma
ICAM-1
tumor
factor
(TNF)-α,
IL-1β,
IL-6,
IL-10
levels
groups
than
Moreover,
correlation
analysis
showed
that
positively
correlated
erythrocytic
oleic
acid
(C18:1)
negatively
linoleic
(C18:2).
conclusion,
protected
against
lipid
accumulation
inflammation
chronically
ethanol.
