Mulberrin suppresses gastric cancer progression and enhances chemosensitivity to oxaliplatin through HSP90AA1/PI3K/AKT axis
Yongsen Li,
Mengyao Dong,
Hong Qin
и другие.
Phytomedicine,
Год журнала:
2025,
Номер
unknown, С. 156441 - 156441
Опубликована: Янв. 1, 2025
Язык: Английский
Combination therapy with immune checkpoint inhibitors in colorectal cancer: Challenges, resistance mechanisms, and the role of microbiota
Biomedicine & Pharmacotherapy,
Год журнала:
2025,
Номер
186, С. 118014 - 118014
Опубликована: Март 31, 2025
Язык: Английский
Therapeutic potential of chalcone-1,2,3-triazole hybrids as anti-tumour agents: a systematic review and SAR studies
Future Medicinal Chemistry,
Год журнала:
2025,
Номер
17(4), С. 449 - 465
Опубликована: Янв. 31, 2025
The
study
of
chalcone-1,2,3-triazole
hybrids
for
anticancer
activity
is
quite
a
recent
area
focus,
primarily
because
the
increasing
demand
developing
new
drugs
to
treat
cancer.
chalcones
and
1,2,3-triazole
rings
in
hybrid
compounds
has
recently
emerged
as
promising
strategy
novel
agents.
ring,
known
its
stability
hydrogen
bonding
capabilities,
enhances
target
binding
affinity
these
hybrids.
Chalcones
possess
an
α,β-unsaturated
carbonyl
system
crucial
their
synergistic
effect
two
moieties
results
with
potent
properties.
This
review
explores
structure-activity
relationship
studies
which
revealed
that
electronic
lipophilic
properties
substituents
on
phenyl
significantly
influence
activity.
Electron-donating
electron-withdrawing
groups
can
affect
cellular
uptake
engagement.
Incorporating
various
into
ring
improve
selectivity
potency
against
specific
cancer
cell
lines.
These
often
exert
effects
through
apoptosis
cycle
disruption.
Recent
research
indicates
chalcone
hold
therapeutic
promise
Further
optimization
SAR
in-depth
mechanistic
investigations
could
lead
development
highly
selective
agents
minimal
toxicity.
Язык: Английский
Marine-derived secondary metabolites in oncology: A comprehensive review
Current Research in Biotechnology,
Год журнала:
2025,
Номер
unknown, С. 100300 - 100300
Опубликована: Май 1, 2025
Язык: Английский
In Silico Design of Dual Estrogen Receptor and Hsp90 Inhibitors for ER-Positive Breast Cancer Through a Mixed Ligand/Structure-Based Approach
Molecules,
Год журнала:
2024,
Номер
29(24), С. 6040 - 6040
Опубликована: Дек. 21, 2024
Breast
cancer
remains
one
of
the
most
prevalent
and
lethal
malignancies
in
women,
particularly
estrogen
receptor-positive
(ER+)
subtype,
which
accounts
for
approximately
70%
cases.
Traditional
endocrine
therapies,
including
aromatase
inhibitors,
selective
receptor
degraders/antagonists
(SERDs),
modulators
(SERMs),
have
improved
outcomes
metastatic
ER+
breast
cancer.
However,
resistance
to
these
agents
presents
a
significant
challenge.
This
study
explores
novel
therapeutic
strategy
involving
simultaneous
inhibition
(ER)
chaperone
protein
Hsp90,
is
crucial
stabilization
various
oncoproteins,
ER
itself.
We
employed
hybrid,
hierarchical
silico
virtual
screening
approach
identify
new
dual
ER/Hsp90
utilizing
Biotarget
Predictor
Tool
(BPT)
efficient
multitarget
large
compound
library.
Subsequent
structure-based
studies,
molecular
docking
analyses,
were
conducted
further
evaluate
interaction
top
candidates
with
both
Hsp90.
Supporting
this,
dynamics
simulations
demonstrate
high
stability
inhibitor
755435
complex
Our
findings
suggest
that
several
small
molecules,
755435,
exhibit
promising
potential
as
representing
avenue
overcome
Язык: Английский
Architecting lymphoma fusion: PROMETHEE-II guided optimization of combination therapeutic synergy
International Journal of Information Technology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 17, 2024
Язык: Английский
Innovations and Emerging Trends in Prostate Cancer Management: A Literature Review
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Prostate
cancer
(PC)
is
considered
the
second
most
diagnosed
in
men
worldwide.
It
remains
a
leading
cause
of
cancer-related
death.
Recently,
many
modalities
have
been
discovered
and
used
diagnosis
management
PC,
with
incorporation
treatment
options
such
as
hormonal
therapy,
chemotherapy,
targeted
therapies,
immunotherapy,
precision
medicine.
Robotics
artificial
intelligence
(AI)
further
modified
PCs,
improving
accuracy
disease
progression.
This
comprehensive
review
offers
an
in-depth
exploration
historical
treatments,
evaluation
current
therapeutic
techniques,
discussion
use
robotic
surgery
AI,
examination
ongoing
clinical
trials
emerging
procedures.
Additionally,
this
also
covers
challenges.
By
inspecting
these
aspects,
may
provide
valuable
information
regarding
future
research
practice
directions
PC
treatment,
contributing
to
thorough
understanding
complex
context
management.
Язык: Английский