Innovations and Emerging Trends in Prostate Cancer Management: A Literature Review DOI Open Access

Nazeer Ibraheem,

Momen Abdelglil,

Andrew Wanees

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Prostate cancer (PC) is considered the second most diagnosed in men worldwide. It remains a leading cause of cancer-related death. Recently, many modalities have been discovered and used diagnosis management PC, with incorporation treatment options such as hormonal therapy, chemotherapy, targeted therapies, immunotherapy, precision medicine. Robotics artificial intelligence (AI) further modified PCs, improving accuracy disease progression. This comprehensive review offers an in-depth exploration historical treatments, evaluation current therapeutic techniques, discussion use robotic surgery AI, examination ongoing clinical trials emerging procedures. Additionally, this also covers challenges. By inspecting these aspects, may provide valuable information regarding future research practice directions PC treatment, contributing to thorough understanding complex context management.

Language: Английский

Mulberrin suppresses gastric cancer progression and enhances chemosensitivity to oxaliplatin through HSP90AA1/PI3K/AKT axis DOI

Yongsen Li,

Mengyao Dong,

Hong Qin

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156441 - 156441

Published: Jan. 1, 2025

Language: Английский

Citations

3
Combination therapy with immune checkpoint inhibitors in colorectal cancer: Challenges, resistance mechanisms, and the role of microbiota DOI
Ali Rahimi,

Zeinab Baghernejadan,

Ali Hazrati

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118014 - 118014

Published: March 31, 2025

Language: Английский

Citations

1
Therapeutic potential of chalcone-1,2,3-triazole hybrids as anti-tumour agents: a systematic review and SAR studies DOI
Sakshi Priya, Md. Shafiqul Islam,

Shivani Kasana

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 17(4), P. 449 - 465

Published: Jan. 31, 2025

The study of chalcone-1,2,3-triazole hybrids for anticancer activity is quite a recent area focus, primarily because the increasing demand developing new drugs to treat cancer. chalcones and 1,2,3-triazole rings in hybrid compounds has recently emerged as promising strategy novel agents. ring, known its stability hydrogen bonding capabilities, enhances target binding affinity these hybrids. Chalcones possess an α,β-unsaturated carbonyl system crucial their synergistic effect two moieties results with potent properties. This review explores structure-activity relationship studies which revealed that electronic lipophilic properties substituents on phenyl significantly influence activity. Electron-donating electron-withdrawing groups can affect cellular uptake engagement. Incorporating various into ring improve selectivity potency against specific cancer cell lines. These often exert effects through apoptosis cycle disruption. Recent research indicates chalcone hold therapeutic promise Further optimization SAR in-depth mechanistic investigations could lead development highly selective agents minimal toxicity.

Language: Английский

Citations

1
Marine-derived secondary metabolites in oncology: A comprehensive review DOI Creative Commons
Samah S. Abuzahrah, Serag Eldin I. Elbehairi, Tahani Bakhsh

et al.

Current Research in Biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 100300 - 100300

Published: May 1, 2025

Language: Английский

Citations

0
In Silico Design of Dual Estrogen Receptor and Hsp90 Inhibitors for ER-Positive Breast Cancer Through a Mixed Ligand/Structure-Based Approach DOI Creative Commons
Gabriele La Monica, Federica Alamia, Alessia Bono

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 6040 - 6040

Published: Dec. 21, 2024

Breast cancer remains one of the most prevalent and lethal malignancies in women, particularly estrogen receptor-positive (ER+) subtype, which accounts for approximately 70% cases. Traditional endocrine therapies, including aromatase inhibitors, selective receptor degraders/antagonists (SERDs), modulators (SERMs), have improved outcomes metastatic ER+ breast cancer. However, resistance to these agents presents a significant challenge. This study explores novel therapeutic strategy involving simultaneous inhibition (ER) chaperone protein Hsp90, is crucial stabilization various oncoproteins, ER itself. We employed hybrid, hierarchical silico virtual screening approach identify new dual ER/Hsp90 utilizing Biotarget Predictor Tool (BPT) efficient multitarget large compound library. Subsequent structure-based studies, molecular docking analyses, were conducted further evaluate interaction top candidates with both Hsp90. Supporting this, dynamics simulations demonstrate high stability inhibitor 755435 complex Our findings suggest that several small molecules, 755435, exhibit promising potential as representing avenue overcome

Language: Английский

Citations

1
Architecting lymphoma fusion: PROMETHEE-II guided optimization of combination therapeutic synergy DOI
Syed Anas Ansar, Swati Arya,

Nupur Soni

et al.

International Journal of Information Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

Citations

0
Innovations and Emerging Trends in Prostate Cancer Management: A Literature Review DOI Open Access

Nazeer Ibraheem,

Momen Abdelglil,

Andrew Wanees

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Prostate cancer (PC) is considered the second most diagnosed in men worldwide. It remains a leading cause of cancer-related death. Recently, many modalities have been discovered and used diagnosis management PC, with incorporation treatment options such as hormonal therapy, chemotherapy, targeted therapies, immunotherapy, precision medicine. Robotics artificial intelligence (AI) further modified PCs, improving accuracy disease progression. This comprehensive review offers an in-depth exploration historical treatments, evaluation current therapeutic techniques, discussion use robotic surgery AI, examination ongoing clinical trials emerging procedures. Additionally, this also covers challenges. By inspecting these aspects, may provide valuable information regarding future research practice directions PC treatment, contributing to thorough understanding complex context management.

Language: Английский

Citations

0