Near‐Infrared II AIE Luminogens with Mitochondria‐Targeting Characteristics for Combinational Phototherapies of Breast Tumors Through Synergistic Cell Apoptosis and Pyroptosis DOI
Huifang Su, Shangping Wang, Ge Li

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Conventional photosensitizers for tumor phototherapy are greatly limited by their reliance on a single‐cell death process, leading to insufficient therapeutic effects and restricted biomedical applications. To address these limitations, multifunctional fluorophores, BTA BTB, designed based an electron donor‐π‐acceptor system. By adjusting the strength of intramolecular charge transfer through varying electron‐donating moieties, optical properties tailored. emits bright near‐infrared II (NIR‐II) fluorescence exhibits typical aggregation‐induced emission (AIE) characteristics, large Stokes shift (>250 nm), good photostability, satisfactory biocompatibility, remarkable mitochondria‐targeting capabilities. Notably, it demonstrates potent photodynamic photothermal properties. as effective photosensitizer agent, generates various cytotoxic Type I reactive oxygen species energy effectively destroy cell mitochondria suppress growth. Importantly, molecular mechanisms underlying combination elucidated, revealing that induces synergistic apoptosis pyroptosis. These results highlight potential AIE materials with NIR‐II characteristics breast tumors, offering new insights future developments.

Язык: Английский

Engineering Nanozymes for Tumor Therapy via Ferroptosis Self‐Amplification DOI

Shuyu Liu,

Wei Yi,

Yuan Liang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(19)

Опубликована: Апрель 4, 2024

Ferroptosis induction is an emerging strategy for tumor therapy. Reactive oxygen species (ROS) can induce ferroptosis but are easily consumed by overexpressed glutathione (GSH) in cells. Therefore, achieving a large amount of ROS production cells without being key to efficiently inducing ferroptosis. In this study, self-amplifying ferroptosis-inducing therapeutic agent, Pd@CeO

Язык: Английский

Процитировано

5
Advancements in tantalum based nanoparticles for integrated imaging and photothermal therapy in cancer management DOI Creative Commons
Ikhazuagbe H. Ifijen,

Awoyemi Taiwo Christopher,

Ogunnaike Korede Lekan

и другие.

RSC Advances, Год журнала: 2024, Номер 14(46), С. 33681 - 33740

Опубликована: Янв. 1, 2024

Tantalum-based nanoparticles (TaNPs) have emerged as promising tools in cancer management, owing to their unique properties that facilitate innovative imaging and photothermal therapy applications.

Язык: Английский

Процитировано

5
A locally-adapted nanoreactor for autophagy inhibition-enhanced cascade starvation–chemodynamic therapy DOI
Chunhui Wang, Ruihao Li, Chunyan Dong

и другие.

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 695, С. 137820 - 137820

Опубликована: Май 6, 2025

Язык: Английский

Процитировано

0
Nanotechnology-mediated precision drug delivery strategies for breast cancer treatment DOI
Hassan Maleki,

Hammed Tanimowo Aiyelabegan,

Parisa Javadi

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 188, С. 118224 - 118224

Опубликована: Июнь 1, 2025

Язык: Английский

Процитировано

0
Near‐Infrared II AIE Luminogens with Mitochondria‐Targeting Characteristics for Combinational Phototherapies of Breast Tumors Through Synergistic Cell Apoptosis and Pyroptosis DOI
Huifang Su, Shangping Wang, Ge Li

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Conventional photosensitizers for tumor phototherapy are greatly limited by their reliance on a single‐cell death process, leading to insufficient therapeutic effects and restricted biomedical applications. To address these limitations, multifunctional fluorophores, BTA BTB, designed based an electron donor‐π‐acceptor system. By adjusting the strength of intramolecular charge transfer through varying electron‐donating moieties, optical properties tailored. emits bright near‐infrared II (NIR‐II) fluorescence exhibits typical aggregation‐induced emission (AIE) characteristics, large Stokes shift (>250 nm), good photostability, satisfactory biocompatibility, remarkable mitochondria‐targeting capabilities. Notably, it demonstrates potent photodynamic photothermal properties. as effective photosensitizer agent, generates various cytotoxic Type I reactive oxygen species energy effectively destroy cell mitochondria suppress growth. Importantly, molecular mechanisms underlying combination elucidated, revealing that induces synergistic apoptosis pyroptosis. These results highlight potential AIE materials with NIR‐II characteristics breast tumors, offering new insights future developments.

Язык: Английский

Процитировано

1