Near‐Infrared II AIE Luminogens with Mitochondria‐Targeting Characteristics for Combinational Phototherapies of Breast Tumors Through Synergistic Cell Apoptosis and Pyroptosis DOI
Huifang Su, Shangping Wang, Ge Li

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Conventional photosensitizers for tumor phototherapy are greatly limited by their reliance on a single‐cell death process, leading to insufficient therapeutic effects and restricted biomedical applications. To address these limitations, multifunctional fluorophores, BTA BTB, designed based an electron donor‐π‐acceptor system. By adjusting the strength of intramolecular charge transfer through varying electron‐donating moieties, optical properties tailored. emits bright near‐infrared II (NIR‐II) fluorescence exhibits typical aggregation‐induced emission (AIE) characteristics, large Stokes shift (>250 nm), good photostability, satisfactory biocompatibility, remarkable mitochondria‐targeting capabilities. Notably, it demonstrates potent photodynamic photothermal properties. as effective photosensitizer agent, generates various cytotoxic Type I reactive oxygen species energy effectively destroy cell mitochondria suppress growth. Importantly, molecular mechanisms underlying combination elucidated, revealing that induces synergistic apoptosis pyroptosis. These results highlight potential AIE materials with NIR‐II characteristics breast tumors, offering new insights future developments.

Language: Английский

Engineering Nanozymes for Tumor Therapy via Ferroptosis Self‐Amplification DOI

Shuyu Liu,

Wei Yi,

Yuan Liang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: April 4, 2024

Ferroptosis induction is an emerging strategy for tumor therapy. Reactive oxygen species (ROS) can induce ferroptosis but are easily consumed by overexpressed glutathione (GSH) in cells. Therefore, achieving a large amount of ROS production cells without being key to efficiently inducing ferroptosis. In this study, self-amplifying ferroptosis-inducing therapeutic agent, Pd@CeO

Language: Английский

Citations

5
Advancements in tantalum based nanoparticles for integrated imaging and photothermal therapy in cancer management DOI Creative Commons
Ikhazuagbe H. Ifijen,

Awoyemi Taiwo Christopher,

Ogunnaike Korede Lekan

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(46), P. 33681 - 33740

Published: Jan. 1, 2024

Tantalum-based nanoparticles (TaNPs) have emerged as promising tools in cancer management, owing to their unique properties that facilitate innovative imaging and photothermal therapy applications.

Language: Английский

Citations

5
A locally-adapted nanoreactor for autophagy inhibition-enhanced cascade starvation–chemodynamic therapy DOI
Chunhui Wang, Ruihao Li, Chunyan Dong

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 695, P. 137820 - 137820

Published: May 6, 2025

Language: Английский

Citations

0
Near‐Infrared II AIE Luminogens with Mitochondria‐Targeting Characteristics for Combinational Phototherapies of Breast Tumors Through Synergistic Cell Apoptosis and Pyroptosis DOI
Huifang Su, Shangping Wang, Ge Li

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Conventional photosensitizers for tumor phototherapy are greatly limited by their reliance on a single‐cell death process, leading to insufficient therapeutic effects and restricted biomedical applications. To address these limitations, multifunctional fluorophores, BTA BTB, designed based an electron donor‐π‐acceptor system. By adjusting the strength of intramolecular charge transfer through varying electron‐donating moieties, optical properties tailored. emits bright near‐infrared II (NIR‐II) fluorescence exhibits typical aggregation‐induced emission (AIE) characteristics, large Stokes shift (>250 nm), good photostability, satisfactory biocompatibility, remarkable mitochondria‐targeting capabilities. Notably, it demonstrates potent photodynamic photothermal properties. as effective photosensitizer agent, generates various cytotoxic Type I reactive oxygen species energy effectively destroy cell mitochondria suppress growth. Importantly, molecular mechanisms underlying combination elucidated, revealing that induces synergistic apoptosis pyroptosis. These results highlight potential AIE materials with NIR‐II characteristics breast tumors, offering new insights future developments.

Language: Английский

Citations

1