Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 24, 2025
Exosomes,
as
key
mediators
of
intercellular
communication,
have
been
increasingly
recognized
for
their
role
in
the
oncogenic
processes,
particularly
facilitating
drug
resistance.
This
article
delves
into
emerging
evidence
linking
exosomal
lncRNAs
to
modulation
resistance
mechanisms
cancers
such
ovarian,
cervical,
and
endometrial
cancer.
It
synthesizes
current
research
findings
on
how
these
influence
cancer
cell
survival,
tumor
microenvironment,
chemotherapy
efficacy.
Additionally,
review
highlights
potential
therapeutic
strategies
targeting
lncRNAs,
proposing
a
new
frontier
overcoming
By
mapping
interface
resistance,
this
aims
provide
comprehensive
understanding
that
could
pave
way
innovative
treatments
improved
patient
outcomes
female
reproductive
system
cancers.
Язык: Английский
Targeting Wnt Signaling in Cancer Drug Resistance: Insights from Pre-Clinical and Clinical Research
Pathology - Research and Practice,
Год журнала:
2025,
Номер
267, С. 155837 - 155837
Опубликована: Фев. 11, 2025
Язык: Английский
Multitask Learning Model for Predicting Non-coding RNA-Disease Associations: Incorporating Local and Global Context
Methods,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
SNHG family lncRNAs: key players in the breast cancer progression and immune cell’s modulation
Mohamed J. Saadh,
Junainah Abd Hamid,
H. Malathi
и другие.
Experimental Cell Research,
Год журнала:
2025,
Номер
unknown, С. 114531 - 114531
Опубликована: Март 1, 2025
Язык: Английский
Exosomal lncRNAs in the Tumor Angiogenesis: As Therapeutic Targets in Cancer Treatment
Archiv der Pharmazie,
Год журнала:
2025,
Номер
358(4)
Опубликована: Апрель 1, 2025
Abstract
Exosomes,
as
mediators
of
intercellular
communication,
can
be
released
from
different
types
cells
and
regulate
the
function
target
cell
by
transferring
cargo,
such
proteins,
DNA,
RNA.
Recent
investigations
have
revealed
a
preponderance
long
noncoding
RNAs
(lncRNAs),
subclass
RNAs,
within
exosomes,
where
they
exhibit
notable
stability
are
implicated
in
development
progression
neoplastic
processes,
tumor
angiogenesis.
Angiogenesis,
hallmark
cancer,
provides
diffusible
nutrients
oxygen
to
distant
guarantees
tumorigenesis
metastasis.
Exosomal
lncRNAs,
including
MALAT1,
OIP5‐AS1,
PART1,
SNHG
family,
FAM225A,
ATB,
RAMP2‐AS1,
UCA1,
TRPM2‐AS,
FGD5‐AS1,
LINC0016,
could
modulate
angiogenesis
activating
signaling
cascades
cells,
microRNAs
(miRNAs).
Regulation
through
modulation
exosomal
lncRNAs
reliable
strategy
for
cancer
therapy.
In
this
review,
we
discuss
characteristics
biogenesis
exosomes
how
involved
various
processes
tumorigenesis.
Our
primary
focus
is
on
their
impact
angiogenesis,
potential
novel
diagnostic
markers
therapeutic
targets
cancers.
Язык: Английский
LINC01559: roles, mechanisms, and clinical implications in human cancers
Human Cell,
Год журнала:
2025,
Номер
38(3)
Опубликована: Апрель 9, 2025
Язык: Английский
Latest Update on lncRNA in Epithelial Ovarian Cancer—A Scoping Review
Cells,
Год журнала:
2025,
Номер
14(7), С. 555 - 555
Опубликована: Апрель 7, 2025
Long
noncoding
RNAs
(lncRNAs)
are
RNA
molecules
exceeding
200
nucleotides
that
do
not
encode
proteins
yet
play
critical
roles
in
regulating
gene
expression
at
multiple
levels,
such
as
chromatin
modification
and
transcription.
These
significantly
engaged
cancer
progression,
development,
metastasis,
chemoresistance.
However,
the
function
of
lncRNAs
epithelial
ovarian
(EOC)
has
been
thoroughly
studied.
EOC
remains
challenging
due
to
its
complex
molecular
pathogenesis,
characterized
by
genetic
epigenetic
alterations.
Emerging
evidence
suggests
lncRNAs,
XIST,
H19,
NEAT1,
MALAT1,
involved
modulating
signaling
pathways,
influencing
processes
like
cell
proliferation,
invasion,
migration,
Despite
extensive
research,
precise
mechanism
acting
pathogenesis
treatment
resistance
still
needs
be
fully
understood,
highlighting
need
for
further
studies.
This
review
aims
provide
an
updated
overview
current
understanding
EOC,
emphasizing
their
potential
biomarkers
therapeutic
targets.
We
point
out
gaps
knowledge
regarding
lncRNAs’
influence
on
(EOC),
deliberating
new
possible
research
areas.
Язык: Английский
The Role of Exosomal Long Non-Coding RNAs in Tumors and Tumour Metabolism
American Journal of Biomedical and Life Sciences,
Год журнала:
2024,
Номер
12(3), С. 49 - 56
Опубликована: Авг. 27, 2024
Long
non-coding
RNAs
(lncRNAs)
are
that
do
not
have
protein-coding
functions
and
involved
in
a
wide
range
of
important
regulatory
processes
through
four
modes
(1)
signaling
(2)
guidance
(3)
structural
backbone
(4)
decoying,
which
regulate
gene
expression
at
epigenetic,
transcriptional
post-transcriptional
levels.
Exosomes
extracellular
vesicles
released
by
various
cells,
whose
contents
protected
from
degradation
stabilized
the
environment
due
to
their
lipid
bilayer
membrane
structure,
thought
play
an
role
many
diseases,
including
tumors.
The
exosomes
secreted
tumor
cells
stromal
contain
proteins,
nucleic
acids,
lipids,
cytokines,
transcription
factors
other
biologically
active
substances.
With
help
exosomes,
they
stably
transported
between
mediate
exchange
substances
information
order
achieve
intercellular
communication,
thus
affecting
biological
activities
target
cells.
Among
them,
lncRNAs
selectively
sorted
into
can
metabolism
as
well
progression
ways.
In
this
paper,
exosomal
microenvironment
is
reviewed,
with
view
providing
markers,
targets
directions
for
clinical
diagnosis,
therapy
tumor-related
research.
Язык: Английский
Extracellular Vesicle lncRNAs as Key Biomolecules for Cell-to-Cell Communication and Circulating Cancer Biomarkers
Non-Coding RNA,
Год журнала:
2024,
Номер
10(6), С. 54 - 54
Опубликована: Ноя. 5, 2024
Extracellular
vesicles
(EVs)
are
secreted
by
almost
every
cell
type
and
considered
carriers
of
active
biomolecules,
such
as
nucleic
acids,
proteins,
lipids.
Their
content
can
be
uptaken
released
into
the
cytoplasm
recipient
cells,
thereby
inducing
gene
reprogramming
phenotypic
changes
in
acceptor
cells.
Whether
effects
EVs
on
physiology
cells
mediated
individual
biomolecules
or
collective
outcome
total
transferred
EV
is
still
under
debate.
The
RNA
consists
several
types
RNA,
messenger
(mRNA),
microRNA
(miRNA),
long
non-coding
(lncRNA),
latter
defined
transcripts
longer
than
200
nucleotides
that
do
not
code
for
proteins
but
have
important
established
biological
functions.
This
review
aims
to
update
our
insights
functional
roles
their
cargo
during
cancer
progression,
highlight
utility
novel
diagnostic
prognostic
biomarkers
cancer,
tackle
technological
advances
limitations
identification,
integrity
assessment,
preservation
its
functionality.
Язык: Английский