Glia: The Cellular Glue that binds Circadian Rhythms and Sleep
SLEEP,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Glia
are
increasingly
appreciated
as
serving
an
important
function
in
the
control
of
sleep
and
circadian
rhythms.
Glial
cells
Drosophila
mammals
regulate
daily
rhythms
locomotor
activity
well
homeostatic
rebound
following
deprivation.
In
addition,
they
contribute
to
proposed
functions
sleep,
with
different
mapping
varied
glial
subtypes.
Here,
we
discuss
recent
findings
rodent
models
establishing
a
role
glia
or
regulation
synaptic
plasticity,
brain
metabolism,
removal
cellular
debris
immune
challenges.
These
underscore
relevance
for
benefits
attributed
have
implications
understanding
neurobiological
mechanisms
underlying
associated
disorders.
Язык: Английский
Adopting whole-brain computational modelling to investigate neurophysiological features associated with cognition
The Psychology of learning and motivation/The psychology of learning and motivation,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Modeling of blood flow dynamics in the rat somatosensory cortex
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Abstract
The
cerebral
microvasculature
forms
a
dense
network
of
interconnected
blood
vessels
where
flow
is
modulated
partly
by
astrocytes.
Increased
neuronal
activity
stimulates
astrocytes
to
release
vasoactive
substances
at
the
endfeet,
altering
diameters
connected
vessels.
Our
study
simulated
coupling
between
variations
and
vessel
diameter
changes
driven
astrocytic
in
rat
somatosensory
cortex.
We
developed
framework
with
three
key
components:
vasculature
synthesized
morphologies,
fluid
dynamics
model
compute
each
vascular
segment,
stochastic
process
replicating
effect
endfeet
on
radii.
was
validated
against
experimental
values
from
literature
across
cortical
depths.
found
that
local
vasodilation
astrocyte
increased
flow,
especially
capillaries,
exhibiting
layer-specific
response
deeper
layers.
Additionally,
highest
variability
occurred
emphasizing
their
role
perfusion
regulation.
discovered
impacts
localized,
clustered
manner,
most
segments
influenced
two
neighboring
endfeet.
These
insights
enhance
our
understanding
neurovascular
guide
future
research
flow-related
diseases.
Язык: Английский
ATP Restoration by ATP-Deprived Cultured Primary Astrocytes
Neurochemical Research,
Год журнала:
2024,
Номер
50(1)
Опубликована: Ноя. 16, 2024
Abstract
A
high
cellular
concentration
of
adenosine
triphosphate
(ATP)
is
essential
to
fuel
many
important
functions
brain
astrocytes.
Although
ATP
depletion
has
frequently
been
reported
for
astrocytes,
little
known
on
the
metabolic
pathways
that
contribute
restoration
by
ATP-depleted
Incubation
cultured
primary
rat
astrocytes
in
glucose-free
buffer
60
min
with
mitochondrial
uncoupler
BAM15
lowered
content
around
70%,
total
amount
phosphates
50%
and
adenylate
energy
charge
(AEC)
from
0.9
0.6.
Testing
after
removal
revealed
presence
glucose
as
exclusive
substrate
allowed
cells
restore
within
6
h
80%
initial
content,
while
coapplication
plus
enabled
fully
their
min.
rapid
but
incomplete
transient
was
found
had
exposed
alone.
This
completely
prevented
application
pyruvate
uptake
inhibitor
UK5099,
respiratory
chain
antimycin
or
continuous
BAM15.
However,
these
compounds
strongly
accelerated
release
lactate
cells,
suggesting
ribose
moiety
can
serve
some
via
metabolism.
Finally,
adenosine-accelerated
glucose-fed
inhibited
kinase
ABT-702.
These
data
demonstrate
require
a
complete
both
AMP
precursor.
Язык: Английский
Cognitive disorders: potential astrocyte-based mechanism
Brain Research Bulletin,
Год журнала:
2024,
Номер
unknown, С. 111181 - 111181
Опубликована: Дек. 1, 2024
Cognitive
disorders
are
a
common
clinical
manifestation,
including
deterioration
in
the
patient's
memory
ability,
attention,
executive
power,
language,
and
other
functions.
The
contributing
factors
of
cognitive
numerous
diverse
nature,
organic
diseases
mental
disorders.
Neurodegenerative
type
disease
related
to
pathology
neuronal
death
disruption
glial
cell
balance,
ultimately
accompanied
with
impairment.
Thus,
disorder
frequently
serves
as
an
extremely
critical
indicator
neurodegenerative
impairments
negatively
affect
patients'
daily
lives.
However,
our
understanding
precise
pathogenic
pathways
defects
remains
incomplete.
most
prevalent
kind
cells
central
nervous
system
called
astrocytes.
They
have
unique
significance
cerebral
function
because
their
wide
range
functions
maintaining
homeostasis
system,
regulating
synaptic
plasticity,
so
on.
Dysfunction
astrocytes
is
intimately
linked
disorders,
we
attempting
understand
this
phenomenon
predominantly
from
those
perspectives:
neuroinflammation,
astrocytic
senescence,
connexin,
Ca2+
signaling,
mitochondrial
dysfunction,
glymphatic
system.
Язык: Английский
VII Congress of Russian Biophysicists—2023, Krasnodar, Russia
Biophysical Reviews,
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 13, 2023
Язык: Английский
Commentary: Early-in-life Isoflurane Exposure Alters Resting-state Functional connectivity in Juvenile Non-human Primates
Journal of Immunological Sciences,
Год журнала:
2024,
Номер
8(2), С. 1 - 5
Опубликована: Май 17, 2024
The
concern
about
anesthesia-induced
developmental
neurotoxicity
(AIDN)
in
infants
and
young
children
arises
from
animal
studies
indicating
potential
long-term
neurobehavioral
impairments
following
early-in-life
anesthesia
exposure.
While
initial
clinical
provided
ambiguous
results,
recent
prospective
assessments
indicate
associations
between
exposure
later
behavioral
alterations.
Ethical
constraints
confounding
factors
pose
challenges
establishing
a
direct
causal
link
investigating
its
mechanisms.
This
commentary
on
study
non-human
primates
(NHPs)
focuses
exploring
the
role
of
neuroinflammation
alterations
brain
functional
connectivity
In
juvenile
NHPs,
chronic
astrogliosis
amygdala
correlates
with
this
area
other
regions
impairments,
suggesting
mechanism
for
AIDN.
Despite
acknowledging
study's
limitations,
these
findings
emphasize
need
further
research
larger
cohorts
to
confirm
establish
associated
Язык: Английский
Modeling of Blood Flow Dynamics in Rat Somatosensory Cortex
Biomedicines,
Год журнала:
2024,
Номер
13(1), С. 72 - 72
Опубликована: Дек. 31, 2024
Background:
The
cerebral
microvasculature
forms
a
dense
network
of
interconnected
blood
vessels
where
flow
is
modulated
partly
by
astrocytes.
Increased
neuronal
activity
stimulates
astrocytes
to
release
vasoactive
substances
at
the
endfeet,
altering
diameters
connected
vessels.
Methods:
Our
study
simulated
coupling
between
variations
and
vessel
diameter
changes
driven
astrocytic
in
rat
somatosensory
cortex.
We
developed
framework
with
three
key
components:
vasculature
synthesized
morphologies,
fluid
dynamics
model
compute
each
vascular
segment,
stochastic
process
replicating
effect
endfeet
on
radii.
Results:
was
validated
against
experimental
values
from
literature
across
cortical
depths.
found
that
local
vasodilation
astrocyte
increased
flow,
especially
capillaries,
exhibiting
layer-specific
response
deeper
layers.
Additionally,
highest
variability
occurred
emphasizing
their
role
perfusion
regulation.
discovered
impacted
localized,
clustered
manner,
most
segments
influenced
two
neighboring
endfeet.
Conclusions:
These
insights
enhance
our
understanding
neurovascular
guide
future
research
flow-related
diseases.
Язык: Английский
Polyglucosan body density in the aged mouse hippocampus is controlled by a novel modifier locus on chromosome 1
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 22, 2023
In
aged
humans
and
mice,
aggregates
of
hypobranched
glycogen
molecules
called
polyglucosan
bodies
(PGBs)
accumulate
in
hippocampal
astrocytes.
PGBs
are
known
to
drive
cognitive
decline
neurological
diseases
but
remain
largely
unstudied
the
context
typical
brain
aging.
Here,
we
show
that
arise
autophagy-dysregulated
astrocytes
C57BL/6J
mouse
hippocampus.
To
map
genetic
cause
age-related
PGB
accumulation,
quantified
burden
32
fully
sequenced
BXD-recombinant
inbred
strains,
which
display
a
400-fold
variation
at
16-18
months
age.
A
major
modifier
locus
was
mapped
chromosome
1
72-75
Mb,
defined
as
Язык: Английский