Abstract
The
overuse
and
misuse
of
antibiotics
has
accelerated
the
emergence
bacterial
resistance,
making
treatment
common
infections
increasingly
difficult
challenging.
This
led
to
a
rise
in
infection
rates,
worsened
patient
outcomes,
heightened
mortality
risks.
In
response,
researchers
have
been
exploring
new
antimicrobial
strategies,
with
metal
nanomaterials
controllable
shape
size
gaining
significant
attention
for
their
unique
antibacterial
properties.
Among
these,
silver
(Ag)
copper
(Cu)
(NMs)
stand
out
wide
applications
biomedical
materials
due
effective
mechanisms
when
used
as
drugs.
Ag
Cu
NMs,
exemplifying
biomaterials,
showcase
broad‐spectrum
capabilities,
durable
effects,
low
toxicity,
reduced
likelihood
developing
drug
resistance.
Moreover,
they
are
known
promote
angiogenesis,
them
exceptionally
suitable
biomaterial
applications.
review
underscores
significance
NMs
sector,
detailing
promising
role
play
medical
materials.
Our
aim
is
encourage
further
exploration
utilization
biomaterials
industrial
production
sectors.
Abstract
Nanozymes,
as
innovative
materials,
have
demonstrated
remarkable
potential
in
the
field
of
electrochemical
biosensors.
This
article
provides
an
overview
mechanisms
and
extensive
practical
applications
nanozymes
First,
definition
characteristics
are
introduced,
emphasizing
their
significant
role
constructing
efficient
sensors.
Subsequently,
several
common
categories
nanozyme
materials
delved
into,
including
metal‐based,
carbon‐based,
metal‐organic
framework,
layered
double
hydroxide
nanostructures,
discussing
Regarding
mechanisms,
two
key
roles
particularly
focused
biosensors:
selective
enhancement
signal
amplification,
which
crucially
support
sensor
performance.
In
terms
applications,
widespread
use
nanozyme‐based
biosensors
showcased
various
domains.
From
detecting
biomolecules,
pollutants,
nucleic
acids,
proteins,
to
cells,
providing
robust
means
for
high‐sensitivity
detection.
Furthermore,
insights
into
future
development
is
provided,
encompassing
improvements
optimizations
design
integration,
expansion
application
fields
through
interdisciplinary
collaboration.
conclusion,
this
systematically
presents
biosensors,
offering
valuable
references
prospects
research
field.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(1)
Опубликована: Сен. 24, 2023
Copper
(Cu),
an
indispensable
trace
element
within
the
human
body,
serving
as
intrinsic
constituent
of
numerous
natural
enzymes,
carrying
out
vital
biological
functions.
Furthermore,
nanomaterials
exhibiting
enzyme-mimicking
properties,
commonly
known
nanozymes,
possess
distinct
advantages
over
their
enzyme
counterparts,
including
cost-effectiveness,
enhanced
stability,
and
adjustable
performance.
These
advantageous
attributes
have
captivated
attention
researchers,
inspiring
them
to
devise
various
Cu-based
nanomaterials,
such
copper
oxide,
Cu
metal-organic
framework,
CuS,
explore
potential
in
enzymatic
catalysis.
This
comprehensive
review
encapsulates
most
recent
advancements
illuminating
applications
realm
biochemistry.
Initially,
it
is
delved
into
emulation
typical
types
achieved
by
nanomaterials.
Subsequently,
latest
breakthroughs
concerning
nanozymes
biochemical
sensing,
bacterial
inhibition,
cancer
therapy,
neurodegenerative
diseases
treatment
discussed.
Within
this
segment,
also
explored
modulation
nanozyme
activity.
Finally,
a
visionary
outlook
for
future
development
presented.
Nanoscale,
Год журнала:
2023,
Номер
15(31), С. 12853 - 12867
Опубликована: Янв. 1, 2023
Nanozymes,
which
can
be
defined
as
nanomaterials
with
excellent
catalytic
function,
are
well
known
to
the
scientific
community
due
their
distinct
merits,
such
low
cost
and
high
stability,
render
them
preferable
natural
enzymes.
As
porous
organic-inorganic
coordination
materials,
metal-organic
frameworks
(MOFs)
possess
a
large
number
of
active
sites
thus
effectively
mimic
properties
Recently,
MOF-based
nanozymes
have
also
exhibited
good
application
potential
for
analysis
heavy
metal
ions.
In
comparison
traditional
detection
methods
ions,
nanozyme-based
colorimetric
sensing
permits
intuitive
visual
by
using
relatively
simple
instruments,
facilitating
rapid
on-site
screening.
this
minireview,
preparation
different
nanozyme
activity
types
briefly
described,
peroxidase-like
oxidase-like,
relevant
mechanisms
elaborated.
Based
on
this,
response
turn-off,
turn-on,
turn-off-on,
discussed.
addition,
applications
ions
summarized.
Finally,
current
research
status
future
development
direction
Biosensors,
Год журнала:
2024,
Номер
14(8), С. 403 - 403
Опубликована: Авг. 21, 2024
The
convenient
and
sensitive
detection
of
metabolites
is
great
significance
for
understanding
human
health
status
drug
development.
Solid-phase
electrochemiluminescence
(ECL)
enzyme
electrodes
show
potential
in
metabolite
based
on
the
enzyme-catalyzed
reaction
product
hydrogen
peroxide
(H2O2).
Herein,
a
solid-phase
ECL
sensor
was
fabricated
confined
emitter
an
immobilized
using
electrostatic
nanocage
array,
constructing
platform
cholesterol.
cage
nanochannel
consists
bipolar
bilayer
vertically
aligned
mesoporous
silica
film
(bp-VMSF).
upper
layer
bp-VMSF
amino-modified,
positively
charged
VMSF
(p-VMSF),
lower
negatively
(n-VMSF).
most
commonly
used
probe
tris(bipyridine)ruthenium(II)
(Ru(bpy)32+)
fixed
n-VMSF
by
adsorption
from
repulsion
p-VMSF,
generating
significantly
enhanced
stable
signals.
successful
preparation
characterized
scanning
electron
microscopy
(SEM)
electrochemical
methods.
After
amino
groups
outer
surface
were
derivatized
with
aldehyde,
cholesterol
oxidase
(ChOx)
molecules
covalently
immobilized.
construction
electrode
cyclic
voltammetry
(CV)
impedance
spectroscopy
(EIS).
When
corresponding
substrate,
cholesterol,
present
solution,
signal
Ru(bpy)32+
quenched
H2O2,
enabling
high-sensitivity
linear
range
detecting
0.05
mM
to
5.0
mM,
limit
(LOD)
1.5
μM.
