Aquatic Invertebrate Antimicrobial Peptides in the Fight Against Aquaculture Pathogens

Microorganisms, Год журнала: 2025, Номер 13(1), С. 156 - 156

Опубликована: Янв. 14, 2025

The intensification of aquaculture has escalated disease outbreaks and overuse antibiotics, driving the global antimicrobial resistance (AMR) crisis. Antimicrobial peptides (AMPs) provide a promising alternative due to their rapid, broad-spectrum activity, low AMR risk, additional bioactivities, including immunomodulatory, anticancer, antifouling properties. AMPs derived from aquatic invertebrates, particularly marine-derived, are well-suited for aquaculture, offering enhanced stability in high-salinity environments. This study compiles analyzes data AMP databases over 200 scientific sources, identifying approximately 350 mostly cationic α-helical, across 65 protein families. While vitro assays highlight potential, limited vivo studies hinder practical application. These could serve as feed additives, therapeutic agents, or genetic engineering approaches like CRISPR/Cas9-mediated transgenesis enhance resilience farmed species. Despite challenges such stability, ecological impacts, regulatory hurdles, advancements peptidomimetics hold significant promise. Future research should emphasize refining enhancement techniques, expanding diversity bioactivity profiles, prioritizing comprehensive evaluations. Harnessing potential represents step forward on path sustainability, reducing antibiotic dependency, combating AMR, ultimately safeguarding public health ecosystem resilience.

Язык: Английский

Insights into molecular aspects of pathogenesis and disease management in acute hepatopancreatic necrosis disease (AHPND): An updated review

Fish & Shellfish Immunology, Год журнала: 2023, Номер 142, С. 109138 - 109138

Опубликована: Окт. 5, 2023

Язык: Английский