Targeting Gut Microbiota with Probiotics and Phenolic Compounds in the Treatment of Atherosclerosis: A Comprehensive Review

Foods, Год журнала: 2024, Номер 13(18), С. 2886 - 2886

Опубликована: Сен. 12, 2024

Atherosclerosis (AS) is a chronic inflammatory vascular disease. Dysregulated lipid metabolism, oxidative stress, and inflammation are the major mechanisms implicated in development of AS. In addition, evidence suggests that gut dysbiosis plays an important role atherogenesis, modulation microbiota with probiotics phenolic compounds has emerged as promising strategy for preventing treating It been shown can improve atherosclerosis-related parameters by improving profile, inflammation. these may modulate diversity composition atherosclerosis. The studies evaluated present review showed compounds, when consumed individually, improved atherosclerosis modulating various ways, such decreasing permeability, TMAO LPS levels, altering alpha beta diversity, increasing fecal bile acid loss. However, no study was found combined use to available literature highlights synergistic potential between their health-promoting properties functionalities. This aims summarize on individual effects AS, while providing insights into benefits nutraceutical approaches using probiotic strains, quercetin, resveratrol adjuvant therapies AS treatment through microbiota.

Язык: Английский

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The dynamics impact of phlorizin on gut microbiota and metabolites in an in vitro fermentation model

Food Research International, Год журнала: 2025, Номер 205, С. 115930 - 115930

Опубликована: Фев. 7, 2025

Язык: Английский

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Antibacterial and Anti-virulence Properties of Cell-free Supernatant from a Mixture of Limosilactobacillus fermentum Strains Against Enterotoxigenic Escherichia coli

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Язык: Английский

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Impact of a Limosilactobacillus fermentum, Quercetin, and Resveratrol Nutraceutical on Fecal Microbiota Composition and Metabolic Activity in Healthy and Hypertensive Subjects

Foods, Год журнала: 2025, Номер 14(6), С. 986 - 986

Опубликована: Март 14, 2025

A promising strategy to improve the gut microbiome in hypertension is target microbiota. This study evaluated effects of a potential nutraceutical product composed three strains Limosilactobacillus (L.) fermentum, quercetin, and resveratrol on intestinal healthy hypertensive subjects. The consisting L. fermentum 139, 263 296, fructooligosaccharides (200 mg), quercetin (160 (150 mg) (LfQR) was added vitro fecal fermentation process occurring for 48 h. Fecal samples subjects were allocated into four groups: (i) controls (CTL); (ii) with addition LfQR (CTL + LfQR); (iii) (HTN) subjects; (iv) (HTN LfQR). diversity composition microbiota production microbial metabolites evaluated. CTL HTN groups exhibited distinct composition, as shown by β-diversity assessment. potentially nutraceutical-modulated similar between groups, suggesting after addition. increased relative abundance Enterobacteriaceae group that Lachnospiraceae group. media showed higher levels sugars (maltose, fructose, glucose), lactic acid, ethanol, succinic acetic acid compared media. Although results are heterogeneous media, it demonstrated formulation can modulate its metabolic activity.

Язык: Английский

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A Mix of Potentially Probiotic Limosilactobacillus fermentum Strains Alters the Gut Microbiota in a Dose- and Sex-Dependent Manner in Wistar Rats

Microorganisms, Год журнала: 2024, Номер 12(4), С. 659 - 659

Опубликована: Март 26, 2024

Multi-strain Limosilactobacillus (L.) fermentum is a potential probiotic with reported immunomodulatory properties. This study aimed to evaluate the composition, richness, and diversity of gut microbiota in male female rats after treatment multi-strain L. at different doses. Thirty (fifteen fifteen female) were allocated into control group (CTL), receiving dose 108 CFU (Lf-108), 1010 (Lf-1010) for 13 weeks. Gut serum cytokine levels evaluated treatment. Male CTL had lower relative abundance Bifidobacteriaceae Prevotella alpha than their counterparts (p < 0.05). In addition, higher Firmicutes/Bacteroidetes (F/B) ratio rats, administration decreased Anaerobiospirillum increased Lactobacillus F/B Lachnospiraceae The alpha-diversity negatively correlated IL1β (r = −0.44) TNFα −0.39), respectively. identified important changes between showed that may have more beneficial effects on females, while result rats.

Язык: Английский

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ClpL Chaperone as a Possible Component of the Disaggregase Activity of Limosilactobacillus fermentum U-21

Опубликована: Май 27, 2024

Strain L. fermentum U-21 secretes chaperones into the medium and it is considered as candidate for development of drugs, so-called disaggregases, Parkinson&rsquo;s disease therapy. This study devoted to characterization secreted protein encoded by C0965_000195 locus. Analysis sequence predicted structure allows us attribute ClpL, homologs which are known be chaperones. The chaperone activity ClpL was evaluated in vivo refolding differing thermostability luciferases from Aliivibrio fischeri Photorhabdus luminescens Escherichia coli cells. It observed that clpL can compensate deficiency clpB gene enhance ability refold thermodenatured proteins clpB- In vitro experiments have demonstrated a spent culture containing cells, including prevent thermodenaturation partially.We suggest strain, exhibits disaggregase properties against aggregating proteins, may one clue components play role pharmabiotic this strain.

Язык: Английский

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Action and immunomodulatory mechanisms, formulations, and safety concerns of probiotics

Bioscience of Microbiota Food and Health, Год журнала: 2024, Номер 44(1), С. 4 - 15

Опубликована: Авг. 29, 2024

The global probiotics market has been continuously growing, driven by consumer demand for immune-enhancing functional foods, dietary supplements, and natural therapeutics gastrointestinal gut function-mediated diseases. Probiotic microorganisms represent a diverse group of strains with complex but generalized mechanistic patterns. This review describes the various immunomodulatory mechanisms which exert their effects, including competitive exclusion pathogenic microbes, production antimicrobial substances, modulation immune system, improvement barrier function. In addition, formulations methods delivery safety concerns associated these products are also discussed.

Язык: Английский

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ClpL Chaperone as a Possible Component of the Disaggregase Activity of Limosilactobacillus fermentum U-21

Biology, Год журнала: 2024, Номер 13(8), С. 592 - 592

Опубликована: Авг. 6, 2024

The

Язык: Английский

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Genome mining, probiotic characteristics, and in-silico safety assessment of Limosilactobacillus fermentum AV7 isolated from Avocado fruit pulp

LWT, Год журнала: 2024, Номер unknown, С. 117231 - 117231

Опубликована: Дек. 1, 2024

Язык: Английский

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Probiotic therapy as a promising strategy for gestational diabetes mellitus management

Expert Opinion on Biological Therapy, Год журнала: 2024, Номер unknown

Опубликована: Сен. 26, 2024

Gestational diabetes mellitus (GDM) has become the most common pregnancy medical complication, and its prevalence increased in recent years. The GDM treatment primarily relies on adopting healthy eating habits, physical exercise, insulin therapy. However, using probiotics to modulate gut microbiota been subject of clinical trials as a promising therapeutic strategy for management.

Язык: Английский

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