Antioxidants,
Год журнала:
2024,
Номер
13(11), С. 1386 - 1386
Опубликована: Ноя. 14, 2024
Background:
The
gut
microbiota
constitutes
a
complex
microorganism
community
that
harbors
bacteria,
viruses,
fungi,
protozoa,
and
archaea.
human
bacterial
has
been
extensively
proven
to
participate
in
metabolism,
immunity,
nutrient
absorption.
Its
imbalance,
namely
“dysbiosis”,
linked
disordered
metabolism.
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
one
of
the
features
deranged
metabolism
leading
cause
cirrhosis
hepatocellular
carcinoma.
Thus,
there
pathophysiological
link
between
dysbiosis
MASLD.
Aims
Methods:
We
aimed
review
literature
data
on
composition
its
MASLD
describe
concept
“gut–liver
axis”.
Moreover,
we
reviewed
approaches
for
modulation
treatment.
Results:
There
consolidated
evidence
particular
associated
with
stages.
model
explaining
relationship
bidirectional
organization,
physiopathology
Oxidative
stress
keystones
pathophysiology
fibrosis
generation.
promising
efficacy
pre-
probiotics
reversing
patients,
therapeutic
effects.
Few
yet
encouraging
fecal
transplantation
(FMT)
are
available
literature.
Conclusions:
characteristic
key
target
reversal
treatment
via
diet,
pre/probiotics,
FMT
remains
treatment,
prevention,
reversal.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 23
Опубликована: Янв. 3, 2025
Cronobacter
spp.
exhibit
remarkable
resilience
to
extreme
environmental
stresses,
including
thermal,
acidic,
desiccation,
and
osmotic
conditions,
posing
significant
challenges
food
safety.
Their
thermotolerance
relies
on
heat
shock
proteins
(HSPs),
genomic
islands,
enhanced
DNA
repair
mechanisms,
metabolic
adjustments,
ensuring
survival
under
high-temperature
conditions.
Acid
tolerance
is
achieved
through
internal
pH
regulation,
acid
efflux
pumps,
proteins,
allowing
in
acidic
matrices
the
gastrointestinal
tract.
Desiccation
mediated
by
accumulation
of
protective
osmolytes
like
trehalose,
stabilizing
membranes
withstand
dryness,
especially
dry
products.
Similarly,
stress
supported
compatible
solutes
such
as
trehalose
glycine
betaine,
along
with
adaptations
balance
pressures.
These
mechanisms
highlight
adaptability
diverse
environments.
Moreover,
exposure
sublethal
heat,
osmotic,
dry,
may
induce
homologous
or
cross-resistance,
complicating
control
strategies.
Understanding
these
essential
mitigate
risks
spp.,
powdered
infant
formula
(PIF),
ensure
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
With
growing
recognition
of
the
pivotal
role
gut
microbiota
in
human
health,
probiotics
have
gained
widespread
attention
for
their
potential
to
restore
microbial
homeostasis.
However,
a
critical
challenge
persists:
limited
colonization
efficiency
among
most
probiotic
strains
compromises
therapeutic
efficacy.
This
overview
synthesizes
ecological
principles
with
cutting-edge
microbiome
research
elucidate
dynamic
interplay
between
dietary
components
and
within
intestinal
niche.
systematically
analyzes:
(1)
stage-specific
mechanisms
spanning
introduction,
establishment,
proliferation;
(2)
nutrient-driven
modulation
composition
function;
(3)
dual
common
patterns
as
both
facilitators
disruptors
persistence.
Notably,
this
identifies
key
strategies,
including
precision
delivery
prebiotic
fibers
polyphenol-microbiota
crosstalk,
that
enhance
niche
adaptation
through
pH
optimization,
adhesion
potentiation,
competitive
exclusion
pathogens.
Furthermore,
critically
evaluates
current
limitations
research,
particularly
strain-specific
variability
methodological
constraints
simulating
host-microbe-diet
tripartite
interactions.
To
bridge
these
gaps,
proposes
an
interdisciplinary
framework
integrating
omics-driven
strain
selection,
engineered
systems,
personalized
nutrition
models.
Collectively,
work
advances
mechanistic
understanding
diet-microbiota
interactions
while
providing
actionable
insights
developing
targeted
therapies
evidence-based
interventions
optimize
ecosystem
resilience.
