Sarcopenia and Muscle Aging: A Brief Overview

Endocrinology and Metabolism, Год журнала: 2020, Номер 35(4), С. 716 - 732

Опубликована: Дек. 24, 2020

The world is facing the new challenges of an aging population, and understanding process has therefore become one most important global concerns. Sarcopenia a condition which defined by gradual loss skeletal muscle mass function with age. In research clinical practice, sarcopenia recognized as component geriatric disease current target for drug development. this review we define provide overview therapeutic approaches. We further highlight recent findings that describe key pathophysiological phenotypes condition, including alterations in fiber types, mitochondrial function, nicotinamide adenine dinucleotide (NAD⁺) metabolism, myokines, gut microbiota, aged compared to young or healthy muscle. last part examines avenues promising treatment targets. There still no accepted therapy humans. Here brief state derived from various mouse models human samples novel routes development effective therapeutics maintain health during aging.

Язык: Английский

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Prevotella copri alleviates sarcopenia via attenuating muscle mass loss and function decline

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2023, Номер 14(5), С. 2275 - 2288

Опубликована: Авг. 17, 2023

The gut microbiome and fecal metabolites have been found to influence sarcopenia, but whether there are potential bacteria that can alleviate sarcopenia has under-investigated, the molecular mechanism remains unclear.

Язык: Английский

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Prevalence of mental health in relation to religious practices in a contemporary small-scale older Amdo Tibetans

PLOS mental health., Год журнала: 2025, Номер 2(1), С. e0000099 - e0000099

Опубликована: Янв. 2, 2025

Amdo Tibetans, a devout and cohesive non-industrial society, intertwine religious practices, such as pray, kowtow, pilgrimage, aspect of their private public lives. This unique cultural framework fosters profound connection between practices health behaviors. The primary aim this study was to assess the links (pray, pilgrimage) mental health, well physical activity function among older Tibetans. A cross-sectional field survey conducted involving 538 agropastoral Tibetans aged ≥40, situated in eastern Tibetan Plateau. Evaluated various scales, including psychological well-being (Resilience (SRS-7) Flourish (SFI-12)), distress (Depression (CESD-8) Anxiety (GAD-7), social integration (F_SozU K-6), were assessed, along with objectively measured parameters moderate-vigorous (MVPA), sleep duration, grip strength, gait speed, walking endurance. Multivariable linear regression models used associations. Bonferroni correction applied for multiple testing, adjusting socio-demographic characteristics, status, behavior. revealed significant positive associations participation well-being, integration, self-rated inverse observed distress. MVPA positively correlated daily kowtow. Daily kowtow also showed duration. In terms function, prayer negatively associated while exhibited correlations strength but distant pilgrimage no significant. Religious presenting complex contrasting effects on functional health. contrast industrialized societies, culture provides distinctive lens exploring relationship religion

Язык: Английский

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Possible Sarcopenia and Impact of Dual-Task Exercise on Gait Speed, Handgrip Strength, Falls, and Perceived Health

Frontiers in Medicine, Год журнала: 2021, Номер 8

Опубликована: Апрель 16, 2021

Background: Sarcopenia is defined as a progressive age-related loss in muscle mass and strength affecting physical performance. It associated with many negative outcomes including falls, disability, cognitive decline, mortality. Protein enriched diet resistance training have shown to improve function but there limited evidence on impact of dual-task exercise possible sarcopenia. Objective: To evaluate community-based sarcopenia by either slow gait (SG) or poor handgrip (HGS). The secondary aims include effect cognition, frailty, social isolation, perceived health. Methods: Community-dwelling older adults ≥60 years old were recruited from screening program intended identify seniors at risk, invited participate called HAPPY (Healthy Aging Promotion Program for You). One hundred eleven participants completed 3 months follow-up. Questionnaire was administered demographics, sarcopenia, health, network, functional, status. Physical performance included assessment HGS, speed, Short Performance Battery test (SPPB). Results: mean age the Exercise group 75.9 73.0% women. had more female (73.0 vs. 47.5%), (75.9 72.5 old), higher prevalence falls (32.4 15.0%), lower BMI (23.7 25.8), education (4.0 7.2 years). speed increased significantly significant reduction SG HGS. All components SPPB well total score while pre-frailty dropped half. risk isolation reduced 25% improvement health cognition group. Significant persisted after adjustment baseline factors. Conclusion: Dual-task effective improving score, reducing HGS frailty. Future prospective randomized control trials are needed effectiveness interventions reversing

Язык: Английский

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Toward the recognition and management of sarcopenia in routine clinical care

Nature Aging, Год журнала: 2021, Номер 1(11), С. 982 - 990

Опубликована: Ноя. 11, 2021

Язык: Английский

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The prevalence and associated factors of motoric cognitive risk syndrome in multiple ethnic middle‐aged to older adults in west China: a cross‐sectional study

European Journal of Neurology, Год журнала: 2022, Номер 29(5), С. 1354 - 1365

Опубликована: Янв. 20, 2022

Abstract Background and purpose Motoric cognitive risk (MCR) syndrome characterized by subjective complaints slow gait has been proposed validated as a pre‐dementia syndrome. The overall specific ethnic prevalence of MCR the associated factors are poorly understood in middle‐aged to older community‐dwelling residents west China. Methods present study included 6091 samples from prospective cohort study, West China Health Aging Trend (WCHAT). Multidimensional demography, lifestyle, social support, anthropometrics body components, clinical status were investigated analyzed univariate multivariate logistic regression models. Lasso K‐fold cross‐validation conducted construct most predictive model with fitted factors. Results was 9.74%, ethnically 14.25% Tibetan, 11.03% Yi, 10.72% Han, 5.18% Uighur 4.55% Qiang, respectively. In adjusted models, positively diabetes mellitus (odds ratio [OR] = 1.51, p 0.007), osteoarthritis (OR 1.50, 0.002), depression 1.36, 0.005), poor sleep 1.21, 0.045), comorbidity 1.49, 0.001) falls last 12 months 1.34, 0.031). Of note, every 1‐unit increase value stroke an approximate 3‐fold higher having MCR, whilst high‐density lipoprotein 30% lower MCR,respectively. Conclusions Profiles aspects ethnicity presenium stage need further exploration. It is promising strategy apply primary prevention tool prevent dementia.

Язык: Английский

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High Intensity Interval Training: A Potential Method for Treating Sarcopenia

Clinical Interventions in Aging, Год журнала: 2022, Номер Volume 17, С. 857 - 872

Опубликована: Май 1, 2022

Abstract: Sarcopenia, an age-related disease characterized by loss of muscle strength and mass, has attracted the attention medical experts due to its severe morbidity, low living quality, high expenditure health care, mortality. Traditionally, persistent aerobic exercise (PAE) is considered as a valid way attenuate muscular atrophy. However, nowadays, intensity interval training (HIIT) emerged more effective time-efficient method replace traditional modes. HIIT displays comprehensive effects on capacity skeletal metabolism, it provides time-out for recovery cardiopulmonary functions without causing adverse effects. Studies demonstrated that compared with PAE, showed similar or even higher in improving strength, enhancing physical performances increasing mass elder people. Therefore, might become promising cope function. worth mentioning no study was conducted directly sarcopenia patients, which attributed suspicious safety validity. In this review, we will assess different parameters sarcopenia, summarize previous papers PAE quality function, evaluate potential status treating old people atrophy modality; point out drawbacks temporary experiments. Our aim discuss feasibility treat provide reference clinical scientists who want utilize new sarcopenia. Keywords: training, exercise, aging

Язык: Английский

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Factors Associated with Sarcopenia among Elderly Individuals Residing in Community and Nursing Home Settings: A Systematic Review with a Meta-Analysis

Nutrients, Год журнала: 2023, Номер 15(20), С. 4335 - 4335

Опубликована: Окт. 11, 2023

To investigate the factors associated with sarcopenia in elderly individuals residing nursing homes and community settings, we conducted a systematic search of databases, including MEDLINE, EMBASE, PubMed, Web Science Cochrane, up to May 2023. We incorporated total 70 studies into our analysis. Our findings revealed that prevalence ranged from 25% 73.7%, while it varied 5.2% 62.7%. The both settings included male gender, BMI, malnutrition, osteoarthritis. In these comprised age, poor nutrition status, small calf circumference, smoking, physical inactivity, cognitive impairment, diabetes, depression heart disease. Currently, European Working Group on Sarcopenia Older People (EWGSOP) Asian for (AWGS) standards are widely utilized EWGSOP standard being more applicable homes. Identifying is paramount significance, particularly considering some them can be modified managed. Further research warranted impact preventive measures management among settings.

Язык: Английский

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Diagnostic Performance of Clinical Laboratory Indicators With Sarcopenia: Results From the West China Health and Aging Trend Study

Frontiers in Endocrinology, Год журнала: 2021, Номер 12

Опубликована: Дек. 10, 2021

Background Sarcopenia is an age-related and skeletal muscle disorder involving the loss of mass or strength, physiological function. Although diagnostic indicators used in different guidelines are for mass, strength physical performance, there currently no uniform criteria. Therefore, we aimed to explore relationship between a series biomarkers with sarcopenia southwest China. Methods We included 4302 patients from West China Health Aging Trend (WCHAT) study. was defined according Asian Working Group Sarcopenia: 2019 Consensus Update on Diagnosis Treatment. Thyroxine、albumin、total protein、prealbumin、albumin globulin ratio (A/G)、25(OH)VD、fasting insulin、adrenal cortisol、triglyceride、high-density lipoprotein、hemoglobin aspartate aminotransferase alanine (AST/ALT) were measured. The receiver operating characteristic curves (ROC) established describe predictive value also multivariate logistic regression analysis identify risk factors disease. Results In terms protein state, had lower total protein, albumin, prealbumin, A/G than control ( P <0.001). Patients triglyceride but higher high-density lipoprotein compared healthy lipid metabolism aspect hormone free triiodothyronine, fasting insulin tetraiodothyronine adrenal cortisol level (AUC=0.686) AST/ALT (AUC=0.682) best predictors among biomarkers. performance combined (AUC=0.720) equal multiple (AUC=0.742). Conclusion exhibits good sarcopenia.

Язык: Английский

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Which pathway of the possible sarcopenia algorithm of the AWGS 2019 guideline is the best in Korean community-dwelling older men and women?

Archives of Gerontology and Geriatrics, Год журнала: 2025, Номер 131, С. 105778 - 105778

Опубликована: Фев. 6, 2025

Язык: Английский

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