Arquivos do Mudi,
Год журнала:
2023,
Номер
27(ESPECIAL)
Опубликована: Май 11, 2023
Sarcopenic
obesity
is
a
condition
characterized
by
the
simultaneous
presence
of
andsarcopenia,
which
loss
muscle
mass
and
function.
Is
growing
concern,
especiallyamong
elderly
population,
it
important
to
address
both
sarcopeniathrough
lifestyle
modifications,
such
as
exercise
proper
nutrition,
improve
overallhealth
quality
life.
Our
study
aimed
evaluate
effect
HIIT
training
on
themuscle
fiber
area
EDL
in
obese
rats
different
ages.
For
that,
Wistar
rats,
7and
12
months
old,
submitted
or
not
HFD
diet
were
subjected
training,
3
times
aweek,
alternate
days,
for
8
consecutive
weeks.
After
euthanasia
muscles
wascollected
processed
histologically.
data
showed
that
was
able
topromote
hypertrophy
even
with
consumption
this
diet,
indicating
practicingthis
can
stimulate
protein
synthesis
under
conditions
obesity.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4300 - 4300
Опубликована: Апрель 12, 2024
Sarcopenia
is
a
prevalent
degenerative
skeletal
muscle
condition
in
the
elderly
population,
posing
tremendous
burden
on
diseased
individuals
and
healthcare
systems
worldwide.
Conventionally,
sarcopenia
currently
managed
through
nutritional
interventions,
physical
therapy,
lifestyle
modification,
with
no
pharmaceutical
agents
being
approved
for
specific
use
this
disease.
As
pathogenesis
of
still
poorly
understood
there
treatment
recognized
as
universally
effective,
recent
research
efforts
have
been
directed
at
better
comprehending
illness
diversifying
strategies.
In
respect,
paper
overviews
new
advances
correlation
its
underlying
mechanisms.
Specifically,
review
creates
an
updated
framework
sarcopenia,
describing
etiology,
pathogenesis,
risk
factors,
conventional
treatments,
further
discussing
emerging
therapeutic
approaches
like
drug
formulations,
delivery
systems,
stem
cell
therapies,
tissue-engineered
scaffolds
more
detail.
Frontiers in Physiology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 27, 2023
Introduction:
Whether
high-intensity
interval
training
(HIIT)
can
improve
lean
mass,
strength,
and
power
of
the
lower
limbs
in
young
older
people
is
still
under
discussion.
This
study
aimed
to
determine
effect
HIIT
on
maximal
rate
force
development
(RFD),
muscle
both
healthy
adults.
Secondarily,
compare
effects
between
dominant
vs.
non-dominant
each
group.
Materials
methods:
Healthy
(n
=
9;
66
±
6
years;
BMI
27.1
3.1
kg
m-2)
21
1
26.2
2.8
men
underwent
12
weeks
(3x/week)
a
stationary
bicycle.
The
evaluations
were
made
before
after
program
by
dual
energy
X-ray
absorptiometry
(DEXA),
anthropometry,
transducer
and,
Sit-to-Stand
test.
outcomes
analyzed
limb
thigh
circumference,
voluntary
isometric
RFD
(Time
intervals:
0-50,
50-100,
100-200,
0-200
ms),
limbs.
Results:
After
HIIT,
(NDL)
showed
increase
mass
(p
<
0.05)
but
without
interaction
(time*group).
gain
absolute
strength
also
when
adjusted
for
circumference
(DL)
groups.
RFD0-200
ms
differences
groups
interaction.
RFD0-50
NDL
post-training
improvements
Only
group
DL
most
obtained
post-intervention.
In
addition,
post-HIIT
was
observed
0.05),
mainly
Conclusion:
promotes
increases
early
RFD,
individuals.
shown
must
be
future
studies.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(5), С. 1299 - 1299
Опубликована: Фев. 25, 2024
Sarcopenia
is
a
significant
health
concern
primarily
affecting
old
adult
individuals,
characterized
by
age-related
muscle
loss,
and
decreased
strength,
power,
endurance.
It
has
profound
negative
effects
on
overall
quality
of
life,
including
reduced
independence,
mobility,
daily
activity
performance,
osteoporosis,
increased
fall
fracture
risks,
metabolic
issues,
chronic
diseases
like
diabetes
cardiovascular
conditions.
Preventive
strategies
typically
involve
combination
proper
nutrition
regular
physical
activity.
Among
strength
training
exercises,
high-intensity
interval
(HIIT)
stands
out
as
the
most
effective
approach
for
improving
function
in
older
adults
with
sarcopenia.
The
current
review
identifies
summarizes
studies
that
have
examined
HIIT
an
element
prevention
treatment
A
systematic
search
using
several
computerized
databases,
namely,
MEDLINE/PubMed,
Scopus,
SPORTDiscus,
Web
Science,
was
performed
12
January
2023,
according
to
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
(PRISMA)
guidelines.
total
224
were
initially
retrieved.
five
met
selection
criteria.
shows
improvements
body
composition
functional
cardiorespiratory
capacity,
benefits
increases
architecture,
associated
hypertrophy
healthy
adults.
Nonetheless,
given
shortcomings
primary
research
terms
limited
number
high
risk
bias,
further
warranted.
Metabolites,
Год журнала:
2023,
Номер
13(5), С. 647 - 647
Опубликована: Май 9, 2023
Protein
lysine
lactylation
(Kla)
is
a
novel
protein
acylation
reported
in
recent
years,
which
plays
an
important
role
the
development
of
several
diseases
with
pathologically
elevated
lactate
levels,
such
as
tumors.
The
concentration
donor
directly
related
to
Kla
level.
High-intensity
interval
training
(HIIT)
workout
pattern
that
has
positive
effects
many
metabolic
diseases,
but
mechanisms
by
HIIT
promotes
health
are
not
yet
clear.
Lactate
main
metabolite
HIIT,
and
it
unknown
whether
high
during
can
induce
changes
well
levels
differ
different
tissues
how
time-dependent
are.
In
this
study,
we
observed
specificity
single
on
regulation
mouse
tissues.
addition,
aimed
select
obvious
time
dependence
for
quantitative
omics
analyze
possible
biological
targets
HIIT-induced
regulation.
A
induces
uptake
metabolism,
iWAT,
BAT,
soleus
muscle
liver
proteins,
peak
at
24
h
after
return
steady
state
72
h.
proteins
iWAT
may
affect
pathways
glycolipid
metabolism
highly
associated
de
novo
synthesis.
It
speculated
energy
expenditure,
lipolytic
characteristics
recovery
period
be
iWAT.
Frontiers in Physiology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 5, 2023
Sarcopenia
is
a
chronic
degenerative
disease
affecting
primarily
older
adults.
A
growing
aging
population
gradually
increasing
the
number
of
patients
suffering
from
sarcopenia,
placing
financial
pressure
on
patients’
families
and
society
in
general.
There
strong
link
between
mitochondrial
dysfunction
sarcopenia
pathogenesis.
As
result,
treating
by
improving
an
effective
strategy.
Numerous
studies
have
demonstrated
that
exercise
has
positive
effect
when
sarcopenia.
Exercise
promotes
biogenesis
fusion/division
to
add
new
mitochondria
or
improve
dysfunctional
while
maintaining
calcium
homeostasis,
antioxidant
defense
system,
autophagy
promote
normal
function.
Furthermore,
can
reduce
damage
caused
inhibiting
oxidative
stress,
DNA
damage,
apoptosis.
effectiveness
depends
several
factors,
including
duration,
intensity,
form.
Therefore,
Moderate-intensity
over
4
weeks
potentially
mitigates
adults
ameliorating
dysfunction.
HIIT
potential
as
viable
approach
addressing
aged
rats.
However,
further
investigation
required
validate
its
efficacy
Cancer Medicine,
Год журнала:
2023,
Номер
12(17), С. 17692 - 17705
Опубликована: Авг. 17, 2023
Women
with
breast
cancer
and
improved
survival
often
experience
treatment-related
impairments.
High-intensity
interval
training
(HIIT)
has
emerged
as
a
promising
exercise
therapy
modality
for
adult
patients.
However,
the
overall
effects
of
HIIT
in
patients
remain
scarce
controversial.
Therefore,
we
conducted
systematic
review
meta-analysis
to
comprehensively
evaluate
impact
on
health-related
outcomes
patients.We
searched
PubMed,
Embase,
Web
Science
from
inception
November
7,
2022.
Eligible
studies
included
randomized
controlled
trials
that
compared
interventions
usual
care
(UC)
or
MICT
The
primary
outcome
assessed
was
physical
fitness,
exploratory
body
composition,
blood-borne
biomarkers,
patient-reported
outcomes.
Summary
data
were
extracted,
standardized
mean
differences
(SMD)
calculated
meta-analysis.
For
could
not
be
pooled,
conducted.Our
analysis
19
articles
10
studies,
encompassing
532
participants
who
met
inclusion
criteria.
Pooled
results
demonstrated
superior
UC
improving
peak
oxygen
uptake
(VO2peak
).
SMD
VO2peak
(L/min)
(mL/kg/min)
0.79
(95%
CI
0.13,
1.45)
0.59
0.01,
1.16),
respectively.
No
significant
found
between
groups.
Meta-analyses
composition
biomarkers
showed
no
UC.
Systematic
indicated
favorable
muscle
strength,
fatigue,
emotional
well-being.HIIT
is
time-efficient
alternative
may
also
enhance
strength
alleviate
fatigue
symptoms
should
considered
an
important
component
prescription
care.
Further
larger
cohorts
are
needed
determine
clinical
significance
HIIT-induced
changes
terms
other
women
cancer.
Cells,
Год журнала:
2023,
Номер
12(15), С. 2015 - 2015
Опубликована: Авг. 7, 2023
Faced
with
a
globally
aging
society,
the
maintenance
of
health
and
quality
life
in
older
people
is
very
important.
The
age-related
loss
muscle
mass
strength,
known
as
sarcopenia,
severely
reduces
increases
risks
various
diseases.
In
this
study,
we
investigated
inhibitory
effect
hesperidin
(HES)
on
inflammaging,
intention
evaluating
its
potential
use
treatment
for
sarcopenia.
We
studied
22–26-month-old
mice,
corresponding
to
humans
aged
≥70
years,
aging-related
young
mice
3–6
months.
daily
administration
HES
8
weeks
resulted
greater
strength
increased
fiber
size
old
mice.
also
restored
immune
homeostasis
that
had
been
disrupted
by
aging,
such
imbalance
M1/M2
macrophage
ratio.
addition,
found
ameliorated
sarcopenia
regulating
AKT/mammalian
target
rapamycin/forkhead
box
3a
signaling
through
an
increase
insulin-like
growth
factor
(IGF)-1
expression
Therefore,
represents
promising
candidate
inhibitor
people,
effects
are
achieved
homeostasis.
The Journal of Clinical Endocrinology & Metabolism,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 13, 2024
Abstract
Context
Peptidylglycine-α-amidating
monooxygenase
(PAM)
is
a
critical
enzyme
in
the
endocrine
system
responsible
for
activation,
by
amidation,
of
bioactive
peptides.
Objective
To
define
clinical
phenotype
carriers
genetic
mutations
associated
with
impaired
PAM-amidating
activity
(PAM-AMA).
Design
We
used
and
phenotypic
data
from
cohort
studies:
Malmö
Diet
Cancer
(MDC;
1991-1996;
reexamination
2002-2012),
Preventive
Project
(MPP;
2002-2006),
UK
Biobank
(UKB;
2012).
Setting
Exome-wide
association
analysis
was
to
identify
loss-of-function
(LoF)
variants
reduced
PAM-AMA
subsequently
outcomes.
Patients
or
Other
Participants
This
study
included
n∼4500
participants
subcohort
MDC
(MDC-Cardiovascular
cohort),
MPP,
n∼300,000
UKB.
Main
Outcome
Measures
Endocrine-metabolic
traits
suggested
prior
literature,
muscle
mass,
function,
sarcopenia.
Results
Two
LoF
PAM
gene,
Ser539Trp
(minor
allele
frequency:
0.7%)
Asp563Gly
(5%),
independently
contributed
decrease
2.33
[95%
confidence
interval
(CI):
2.52/2.15;
P
=
2.5E−140]
0.98
(1.04/0.92;
1.12E−225)
SD
units
PAM-AMA,
respectively.
The
cumulative
effect
diabetes,
insulin
secretion,
higher
levels
GH
IGF-1.
Moreover,
had
mass
followed
risk
Indeed,
mutation
increased
sarcopenia
30%
(odds
ratio
1.31;
95%
CI:
1.16/1.47;
9.8E−06),
age
diabetes.
Conclusion
deficiency
results
prediabetic
sarcopenic
phenotype.
Early
identification
would
allow
targeted
exercise
interventions
calls
novel
therapies
that
restore
enzymatic
activity.
Introduction
:Stroke
is
a
major
cause
of
long-term
disability
and
reduced
physical
functioning.
It
often
leads
to
muscle
weakness,
wasting,
decreased
cardiovascular
fitness,
which
can
affect
daily
activities.
The
aim
this
study
was
determine
the
effects
high-intensity
interval
training
(HIIT)
on
strength,
atrophy,
aerobic
capacity
in
stroke
patients.
Method
:
single-blinded,
randomized
controlled
trial,
including
34
Patients
were
randomly
allocated
into
two
groups.
One
group
received
HIIT
along
with
conventional
treatment,
other
treatment
alone.
To
measure
calf
circumference,
patients,
MMT,
Measuring
Tape,
6MWT,
Harvard
step
test
used,
respectively.
Results
:Results
showed
significant
difference
between
analysis,
as
p-value
less
than
0.05,
within
group,
both
therapies
effectiveness,
but
paired
differences
A
more
those
B.
Conclusion:
Both
yielded
outcomes.
However,
when
combined
therapy,
program
improved
strength
muscles
atrophy
