Risk factors for low muscle mass, malnutrition, and (probable-) sarcopenia in adults with or without a history of cancer in the UK Biobank

Clinical Nutrition, Год журнала: 2024, Номер 43(7), С. 1736 - 1746

Опубликована: Май 29, 2024

Early identification of people at risk cancer-related malnutrition, low muscle mass (LMM) and sarcopenia is crucial to mitigate the impact adverse outcomes. This study investigated factors associated with LMM, malnutrition (probable-) whether these varied in or without a history cancer.

Язык: Английский

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Dysgeusia in MASLD-related advanced chronic liver disease (ACLD): a silent driver towards the “Bermuda” triangle of malnutrition-sarcopenia-frailty severely affecting prognosis

Nutrition Journal, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 16, 2025

Dysgeusia is a distortion of the sense taste whose prevalence and relationship with nutritional status in Metabolic dysfunction-associated Steatotic Liver Disease (MASLD)-related advanced chronic liver disease (ACLD) have never been systematically explored. 200 MASLD patients [60 ≤ F3 fibrosis, 70 compensated ACLD (cACLD), decompensated (dACLD)] were enrolled. At baseline, Child–Pugh (CP) score was determined. Dietary habits, body composition, frailty evaluated. The European Working Group (EWGSOP2) criteria defined sarcopenia. assessed by Dysgeusia-Total-Score (DTS). A visual analog scale identified appetite impairment (VASAI). During 6-month follow-up, liver-related decompensation events (LRDEs) recorded. dysgeusia increased progression, appearing significantly higher compared (65.7% vs 5%, p:0.003), as well dACLD to cACLD (58.5 7.1% p < 0.0001). On 41 presenting dysgeusia, 37 (90.2%) showed significant levels. In dACLD, CP positively correlated both DTS (R:0.742) VASAI (R:0.704), directly (R:0.765) (all Compared without dysgeusia-affected presented lower daily protein intake (g/kg/die) (1.55 ± 0.192 1.34 0.15, Sarcopenia (70.7 41.3%) (69.29 37.9%) more prevalent individuals (both These risk LRDEs occurrence during follow-up [HR:2.205; C.I. 95%:1.186–4.099; p:0.01]. Logistic regression analysis revealed (aOR: 3.32), (aOR:1.32), sarcopenia 3.75), (aOR:3.03) associated this outcome appears predominant MASLD-dACLD and, via impairment, close malnutrition, sarcopenia, frailty, negatively influencing patients' outcomes.

Язык: Английский

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The simpler modified fried frailty scale predicts 2-year mortality in older adults with heart failure: a pilot study

BMC Geriatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 22, 2025

The Simpler Modified Fried Frailty Scale (SMFFS) has recently been developed from the original scale to ease its use in clinical practice, by transforming items requiring measurements into self-reported inquiries. Its predictive validity needs be clarified, especially populations with a high prevalence of frailty, such as patients heart failure (HF). Primary aim this study is find out frailty older HF using SMFFS and show concordance other assessment tools. Secondary reveal whether useful predict mortality follow-up. This prospective, follow-up including adults (≥ 65 years) HF. was used assess phenotype presence ≥ 3 accepted frailty. FRAIL scale, Study Osteoporosis Fractures (SOF) index, Edmonton (EFS) were alternatively correlation different scales. Cox-regression analysis performed identify SMFFS-defined could follow-up, adjusting for list characteristics geriatric syndromes. Among 101 HF, 44 (42.8%) female. Mean age 75.8 ± 7.6 63.4% according SMFFS. showed strong In median 759 days, cardiomegaly, increased pulmonary artery pressure (PAP) defined only predictors after adjustments age, falls previous year, undernutrition, probable sarcopenia, functional impairments, quality life [HR (95% CI) 3.88 (1.05–14.3), 1.05 (1.01–1.09), 10.96 (1.07–112.05) (p = 0.027); PAP, respectively]. As screening tool, independently associated two years. recommended guidelines risk stratification seems more effectively integrated routine practice easy practical Further large studies are needed support

Язык: Английский

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Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus Cohort

Schweizerische medizinische Wochenschrift, Год журнала: 2025, Номер 155(1), С. 4034 - 4034

Опубликована: Янв. 17, 2025

Sarcopenia is a progressive, age-related loss of muscle mass, strength and function. Given the ageing population adverse outcomes associated with sarcopenia, monitoring its epidemiology particularly important. This study aimed to describe sarcopenia prevalence, 5-year incidence agreement between definitions using latest operational criteria in Swiss postmenopausal women. Postmenopausal women from last 5 years CoLaus/OsteoLaus prospective population-based cohort were included based on complete case analysis (April 2015 October 2022; Lausanne, Switzerland). We assessed appendicular lean mass via Dual X-ray Absorptiometry (GE Lunar iDXA), handgrip Jamar Dynamometer 6-metre gait speed at multiple visits. was defined and/or 11 definitions, including that European Working Group Older People (EWGSOPII, 2019). Prevalence measured as number rate sarcopenic cases visit, while new over 2.5 or years. A total 930 included, mean (standard deviation) age 72.9 (6.9) years, BMI 25.7 (4.8) kg/m2, 16.8 (2.5) kg, 21.2 (5.5) 1.1 (0.2) m/s. prevalence EWGSOPII ranged 2.2% 5.7%, other varied 0.5% 13.4%. The rates 1.9% 4.7%. increased significantly lowest highest tertiles (Fisher's exact test, p <0.05) for most definitions. Agreement predominantly "none" "minimal" according Cohen Kappa score. highlights an increase beginning seventh decade life, underscoring accelerated decline health age. minimal need consensus, which would improve future research clinical implementations.

Язык: Английский

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The challenge of applying the F-A-C-S pathway from EWGSOP2 for sarcopenia diagnosis in patients with chronic obstructive pulmonary disease: A diagnostic accuracy study

Rehabilitación, Год журнала: 2025, Номер 59(1), С. 100879 - 100879

Опубликована: Янв. 1, 2025

Язык: Английский

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Comparison of frailty screening tools in predicting length of stay and disability in older patients on internal medicine inpatient wards transferred from the emergency department: A retrospective observational study

Medicine, Год журнала: 2025, Номер 104(8), С. e41635 - e41635

Опубликована: Фев. 21, 2025

The aim of this study is to compare frailty screening tools in predicting length stay (LOS) older patients on internal medicine inpatient wards transferred from the emergency department (ED). This cross-sectional retrospective involving 186 subjects aged 65 years or was conducted at tertiary hospital ED September November 2023. Frailty defined by Clinical Scale (CFS), identification Seniors At Risk Tool and Triage Risk-Screening (TRST). Dependency Katz Index Independence activities daily living (ADL) Lawton instrumental ADL. presence according CSF TRST associated with a long LOS (coefficient regression β = 0.2 P < .05). But, binary logistic analysis, there no association between scales. All were statistically significant predictors for disability ( .001). Our findings suggest that, among evaluated, CFS may be most robust predictor both functional dependency, although its predictive power actual remains limited. Future studies should focus refining these greater accuracy outcomes examine how factors such as polypharmacy comorbidities impact outcomes. Additionally, longitudinal are needed establish causative relationships frailty, LOS, decline.

Язык: Английский

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Developing a Public-Friendly Sarcopenia Guideline Framework: A model integrating ChatGPT, human experts, and Google (Preprint)

Опубликована: Фев. 26, 2025

The highly academic and complex nature of the current expert consensus on sarcopenia may limit public awareness understanding this disease. This study aims to develop a more public-friendly framework for future guidelines by utilizing model that incorporates Google, Chat Generative Pre-Trained Transformer 4.0 (ChatGPT 4.0), experts. first step human-centered involved identifying most popular questions using “People Also Ask” feature Google. In second step, these were input into ChatGPT generate answers, while experts reviewed existing provide answers. third assessed relevance questions. They compared analyzed responses from reviews, offering suggestions guidelines. Finally, results analysis used as prompts We scored identified 9 was inadequate in answering consensus, diagnostic criteria received highest emphasis, scoring 25.5 points (out 40 points), followed exercise nutrition, each with 13 points. contrast, topics such prognosis symptoms addressed less, score only 5.5 4.5, respectively. integrates 4.0, human experts, Google created guidelines, addressing inadequately covered topics. combines has great potential creating accessible clinical none

Язык: Английский

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The Implementation of Frailty Assessment Tools in the Acute Care Setting: A Scoping Review

Journal of the American Geriatrics Society, Год журнала: 2025, Номер unknown

Опубликована: Март 15, 2025

ABSTRACT Background Frailty is a syndrome of increased vulnerability to health stressors that associated with adverse outcomes. There no universally accepted method measuring frailty, and choosing among the many tools often confusing for clinicians. Moreover, acute care setting presents unique challenges operationalization frailty measurement, implementation into daily clinical practice has been variable. The objective this scoping review was map out synthesize how being measured used in setting. Methods We Arksey O'Malley's methodological framework reviews. searched MEDLINE, EMBASE, CINAHL, SCOPUS, Google Scholar primary studies assessing from inception May 2023. Results Our search resulted 8834 articles, which 2554 met inclusion criteria. Most articles (75%) were published last 5 years. top three most frequently methods measurement Index (41.0%), Clinical Scale (23.3%), Fried Phenotype (9.3%). More than one assessment tool 11.2% studies. While 99.6% evaluate association outcomes or validity specific tools, only 0.4% prospectively adapt healthcare provision. Conclusion an abundance evidence demonstrating outcomes, relatively scarce on effect adapting care. Future research focusing prospective management needed.

Язык: Английский

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Frailty and pituitary surgery: a systematic review

Pituitary, Год журнала: 2025, Номер 28(2)

Опубликована: Март 17, 2025

Abstract Background Frailty is a state of physiological vulnerability rendering patients susceptible to adverse perioperative outcomes after neurosurgery. The effect frailty on surgical success and complication rates in undergoing transsphenoidal pituitary surgery unclear. Methods A systematic review the literature was performed accordance with PRISMA statement. Studies that utilised validated metrics report were included. Results total 13 studies included, comprising 124,989 patients. exclusively assessed cumulative deficit metrics, however there significant heterogeneity patient population, definitions assessment, outcomes. Frail experienced higher medical complications, resulting longer hospital stays, greater hospitalisation costs, unplanned readmission, more discharges destination other than home, increased mortality. These directly correlated increasing degrees frailty. Surgical not affected by frailty, similar biochemical remission, visual recovery, improvement quality life. Conclusion seen minority surgery, but an important indicator risk. assessment should be used as reason withhold rather predict mitigate complications improve surgery.

Язык: Английский

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Application of comprehensive geriatric assessment in oncology nursing: A literature review on optimizing treatment decisions and patient outcomes

World Journal of Clinical Oncology, Год журнала: 2025, Номер 16(4)

Опубликована: Март 26, 2025

With the global population aging, care of elderly cancer patients has become increasingly complex and significant. Comprehensive geriatric assessment (CGA), a multidimensional evaluation tool, been widely implemented in oncology nursing to enhance precision treatment decisions improve patient outcomes. This review examines application CGA nursing, drawing on literature published between 2010 2024 major databases using keywords such as “Comprehensive Geriatric Assessment” “Oncology Nursing”. It highlights how contributes optimizing selection, monitoring process, improving patients’ quality life long-term provides comprehensive patients, including physical, psychological, social aspects, enabling identification high-risk reducing treatment-related side effects complications. also offers critical foundation for developing personalized plans. The article discusses various practical examples implementation across different countries regions, multidisciplinary collaborative models France, United States, Australia, demonstrating CGA’s flexible diverse healthcare settings. Although significant progress made applying numerous challenges remain its implementation, resource limitations insufficient personnel training. Future research will focus integrating with emerging technologies, artificial intelligence medicine, further outcomes patients. By summarizing current status this guidance future clinical practice, emphasizing importance advancing meet growing demands care.

Язык: Английский

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