Neural Regeneration Research,
Год журнала:
2020,
Номер
16(1), С. 58 - 58
Опубликована: Авг. 10, 2020
Aging
is
a
dynamic
and
progressive
process
that
begins
at
conception
continues
until
death.
This
leads
to
decrease
in
homeostasis
morphological,
biochemical
psychological
changes,
increasing
the
individual's
vulnerability
various
diseases.
The
growth
number
of
aging
populations
has
increased
prevalence
chronic
degenerative
diseases,
impairment
central
nervous
system
dementias,
such
as
Alzheimer's
disease,
whose
main
risk
factor
age,
leading
an
increase
individuals
who
need
daily
support
for
life
activities.
Some
theories
about
suggest
it
caused
by
cellular
senescence
reactive
oxygen
species,
which
inflammation,
oxidation,
cell
membrane
damage
consequently
neuronal
Also,
mitochondrial
mutations,
are
generated
throughout
process,
can
lead
changes
energy
production,
deficiencies
electron
transport
apoptosis
induction
result
decreased
function.
Additionally,
release
proinflammatory
cytokines
cause
irreversible
cells.
Recent
reports
point
importance
changing
lifestyle
physical
exercise,
improving
nutrition
environmental
enrichment
activate
neuroprotective
defense
mechanisms.
Therefore,
this
review
aims
address
latest
information
different
mechanisms
related
neuroplasticity
death
provide
strategies
improve
neuroprotection
neurodegeneration
stressors.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2021,
Номер
63(18), С. 3019 - 3045
Опубликована: Сен. 28, 2021
Astaxanthin
is
a
carotenoid
widely
found
in
marine
organisms
and
microorganisms.
With
extensive
use
nutraceuticals,
cosmetics,
animal
feed,
astaxanthin
will
have
the
largest
share
global
market
for
carotenoids
near
future.
Owing
to
its
unique
molecular
features,
has
excellent
antioxidant
activity
holds
promise
biochemical
studies.
This
review
focuses
on
observed
health
benefits
of
dietary
astaxanthin,
as
well
underlying
bioactivity
mechanisms.
Recent
studies
increased
our
understanding
role
isomerization
esterification
structure-function
relationship
astaxanthin.
Gut
microbiota
may
involve
fate
during
digestion
absorption;
thus,
further
knowledge
needed
establish
accurate
recommendations
intake
both
healthy
special
populations.
Associated
with
regulation
redox
balance
multiple
biological
mechanisms,
proposed
affect
oxidative
stress,
inflammation,
cell
death,
lipid
metabolism
humans,
thus
exerting
skin
condition,
eye
health,
cardiovascular
system,
neurological
function,
exercise
performance,
immune
response.
Additionally,
preclinical
trials
predict
potential
effects
such
intestinal
flora
anti-diabetic
activity.
Therefore,
worthy
investigation
boosting
human
wide
applications
food
industry.
Neural Regeneration Research,
Год журнала:
2021,
Номер
16(9), С. 1730 - 1730
Опубликована: Янв. 1, 2021
Parkinson's
disease
(PD)
is
one
of
the
most
debilitating
brain
diseases.
Despite
availability
symptomatic
treatments,
response
towards
health
PD
patients
remains
scarce.
To
fulfil
medical
needs
patients,
an
efficacious
and
etiological
treatment
required.
In
this
review,
we
have
compiled
information
covering
limitations
current
therapeutic
options
in
PD,
novel
drug
targets
for
finally,
role
some
critical
beneficial
natural
products
to
control
progression
PD.
Journal of Neuroinflammation,
Год журнала:
2021,
Номер
18(1)
Опубликована: Ноя. 27, 2021
Microglia
are
integral
mediators
of
innate
immunity
within
the
mammalian
central
nervous
system.
Typical
microglial
responses
transient,
intending
to
restore
homeostasis
by
orchestrating
removal
pathogens
and
debris
regeneration
damaged
neurons.
However,
prolonged
persistent
activation
can
drive
chronic
neuroinflammation
is
associated
with
neurodegenerative
disease.
Recent
evidence
has
revealed
that
abnormalities
in
signaling
pathways
involving
phosphatidylinositol
3-kinase
(PI3K)
protein
kinase
B
(AKT)
may
contribute
altered
activity
exacerbated
neuroimmune
responses.
In
this
scoping
review,
known
suspected
roles
PI3K-AKT
microglia,
both
during
health
pathological
states,
will
be
examined,
key
receptors
induce
microglia
described.
Since
aberrant
correlated
disease
onset,
relationship
between
maladapted
development
also
explored.
Finally,
studies
which
been
modulated
highlighted,
as
prove
a
promising
therapeutic
approach
for
future
treatment
range
neuroinflammatory
conditions.
Neural Regeneration Research,
Год журнала:
2020,
Номер
16(1), С. 58 - 58
Опубликована: Авг. 10, 2020
Aging
is
a
dynamic
and
progressive
process
that
begins
at
conception
continues
until
death.
This
leads
to
decrease
in
homeostasis
morphological,
biochemical
psychological
changes,
increasing
the
individual's
vulnerability
various
diseases.
The
growth
number
of
aging
populations
has
increased
prevalence
chronic
degenerative
diseases,
impairment
central
nervous
system
dementias,
such
as
Alzheimer's
disease,
whose
main
risk
factor
age,
leading
an
increase
individuals
who
need
daily
support
for
life
activities.
Some
theories
about
suggest
it
caused
by
cellular
senescence
reactive
oxygen
species,
which
inflammation,
oxidation,
cell
membrane
damage
consequently
neuronal
Also,
mitochondrial
mutations,
are
generated
throughout
process,
can
lead
changes
energy
production,
deficiencies
electron
transport
apoptosis
induction
result
decreased
function.
Additionally,
release
proinflammatory
cytokines
cause
irreversible
cells.
Recent
reports
point
importance
changing
lifestyle
physical
exercise,
improving
nutrition
environmental
enrichment
activate
neuroprotective
defense
mechanisms.
Therefore,
this
review
aims
address
latest
information
different
mechanisms
related
neuroplasticity
death
provide
strategies
improve
neuroprotection
neurodegeneration
stressors.
