Biomedicine & Pharmacotherapy,
Journal Year:
2021,
Volume and Issue:
137, P. 111377 - 111377
Published: Feb. 16, 2021
Neurodegenerative
diseases
(NDs)
represent
a
common
neurological
pathology
that
determines
progressive
deterioration
of
the
brain
or
nervous
system.
For
treating
NDs,
comprehensive
and
alternative
medicines
have
attracted
scientific
researchers'
attention
recently.
Edible
mushrooms
are
essential
for
preventing
several
age-based
neuronal
dysfunctions
such
as
Parkinson's
Alzheimer's
diseases.
Mushroom
Grifola
frondosa,
Lignosus
rhinocerotis,
Hericium
erinaceus,
may
improve
cognitive
functions.
It
has
also
been
reported
edible
(basidiocarps/mycelia
extracts
isolated
bioactive
compounds)
reduce
beta-amyloid-induced
neurotoxicity.
Medicinal
being
used
novel
natural
compounds
help
modulate
immune
responses
possess
anti-cancer,
anti-microbial,
anti-oxidant
properties.
Compounds
polyphenols,
terpenoids,
alkaloids,
sesquiterpenes,
polysaccharides,
metal
chelating
agents
validated
in
different
ND
treatments.
This
review
aims
to
assess
mushrooms'
role
their
biomolecules
utilization
kinds
NDs.
The
action
mechanisms,
presented
here,
including
reducing
oxidative
stress,
neuroinflammation,
modulation
acetylcholinesterase
activity,
protecting
neurons
stimulation,
regulating
neurotrophins
synthesis.
We
provide
background
about
neurodegenerative
in-silico
techniques
drug
research.
High
costs
associated
with
experiments
current
ethical
law
imply
efficient
alternatives
limited
cost
value.
In
silico
approaches
an
method
low
successfully
implemented
cure
disorders
recent
days.
describe
applications
computational
procedures
molecular
docking,
virtual
high-throughput
screening,
dynamic
(MD)
simulation,
quantum-mechanical
methods
design.
They
were
against
various
targets
Neural Regeneration Research,
Journal Year:
2021,
Volume and Issue:
16(9), P. 1730 - 1730
Published: Jan. 1, 2021
Parkinson's
disease
(PD)
is
one
of
the
most
debilitating
brain
diseases.
Despite
availability
symptomatic
treatments,
response
towards
health
PD
patients
remains
scarce.
To
fulfil
medical
needs
patients,
an
efficacious
and
etiological
treatment
required.
In
this
review,
we
have
compiled
information
covering
limitations
current
therapeutic
options
in
PD,
novel
drug
targets
for
finally,
role
some
critical
beneficial
natural
products
to
control
progression
PD.
Journal of Neuroinflammation,
Journal Year:
2021,
Volume and Issue:
18(1)
Published: Nov. 27, 2021
Microglia
are
integral
mediators
of
innate
immunity
within
the
mammalian
central
nervous
system.
Typical
microglial
responses
transient,
intending
to
restore
homeostasis
by
orchestrating
removal
pathogens
and
debris
regeneration
damaged
neurons.
However,
prolonged
persistent
activation
can
drive
chronic
neuroinflammation
is
associated
with
neurodegenerative
disease.
Recent
evidence
has
revealed
that
abnormalities
in
signaling
pathways
involving
phosphatidylinositol
3-kinase
(PI3K)
protein
kinase
B
(AKT)
may
contribute
altered
activity
exacerbated
neuroimmune
responses.
In
this
scoping
review,
known
suspected
roles
PI3K-AKT
microglia,
both
during
health
pathological
states,
will
be
examined,
key
receptors
induce
microglia
described.
Since
aberrant
correlated
disease
onset,
relationship
between
maladapted
development
also
explored.
Finally,
studies
which
been
modulated
highlighted,
as
prove
a
promising
therapeutic
approach
for
future
treatment
range
neuroinflammatory
conditions.
Neural Regeneration Research,
Journal Year:
2020,
Volume and Issue:
16(1), P. 58 - 58
Published: Aug. 10, 2020
Aging
is
a
dynamic
and
progressive
process
that
begins
at
conception
continues
until
death.
This
leads
to
decrease
in
homeostasis
morphological,
biochemical
psychological
changes,
increasing
the
individual's
vulnerability
various
diseases.
The
growth
number
of
aging
populations
has
increased
prevalence
chronic
degenerative
diseases,
impairment
central
nervous
system
dementias,
such
as
Alzheimer's
disease,
whose
main
risk
factor
age,
leading
an
increase
individuals
who
need
daily
support
for
life
activities.
Some
theories
about
suggest
it
caused
by
cellular
senescence
reactive
oxygen
species,
which
inflammation,
oxidation,
cell
membrane
damage
consequently
neuronal
Also,
mitochondrial
mutations,
are
generated
throughout
process,
can
lead
changes
energy
production,
deficiencies
electron
transport
apoptosis
induction
result
decreased
function.
Additionally,
release
proinflammatory
cytokines
cause
irreversible
cells.
Recent
reports
point
importance
changing
lifestyle
physical
exercise,
improving
nutrition
environmental
enrichment
activate
neuroprotective
defense
mechanisms.
Therefore,
this
review
aims
address
latest
information
different
mechanisms
related
neuroplasticity
death
provide
strategies
improve
neuroprotection
neurodegeneration
stressors.
Biomedicine & Pharmacotherapy,
Journal Year:
2021,
Volume and Issue:
137, P. 111377 - 111377
Published: Feb. 16, 2021
Neurodegenerative
diseases
(NDs)
represent
a
common
neurological
pathology
that
determines
progressive
deterioration
of
the
brain
or
nervous
system.
For
treating
NDs,
comprehensive
and
alternative
medicines
have
attracted
scientific
researchers'
attention
recently.
Edible
mushrooms
are
essential
for
preventing
several
age-based
neuronal
dysfunctions
such
as
Parkinson's
Alzheimer's
diseases.
Mushroom
Grifola
frondosa,
Lignosus
rhinocerotis,
Hericium
erinaceus,
may
improve
cognitive
functions.
It
has
also
been
reported
edible
(basidiocarps/mycelia
extracts
isolated
bioactive
compounds)
reduce
beta-amyloid-induced
neurotoxicity.
Medicinal
being
used
novel
natural
compounds
help
modulate
immune
responses
possess
anti-cancer,
anti-microbial,
anti-oxidant
properties.
Compounds
polyphenols,
terpenoids,
alkaloids,
sesquiterpenes,
polysaccharides,
metal
chelating
agents
validated
in
different
ND
treatments.
This
review
aims
to
assess
mushrooms'
role
their
biomolecules
utilization
kinds
NDs.
The
action
mechanisms,
presented
here,
including
reducing
oxidative
stress,
neuroinflammation,
modulation
acetylcholinesterase
activity,
protecting
neurons
stimulation,
regulating
neurotrophins
synthesis.
We
provide
background
about
neurodegenerative
in-silico
techniques
drug
research.
High
costs
associated
with
experiments
current
ethical
law
imply
efficient
alternatives
limited
cost
value.
In
silico
approaches
an
method
low
successfully
implemented
cure
disorders
recent
days.
describe
applications
computational
procedures
molecular
docking,
virtual
high-throughput
screening,
dynamic
(MD)
simulation,
quantum-mechanical
methods
design.
They
were
against
various
targets
