BioNanoScience, Год журнала: 2024, Номер 15(1)
Опубликована: Дек. 2, 2024
Язык: Английский
BioNanoScience, Год журнала: 2024, Номер 15(1)
Опубликована: Дек. 2, 2024
Язык: Английский
Inorganic Chemistry Communications, Год журнала: 2024, Номер 168, С. 112952 - 112952
Опубликована: Авг. 7, 2024
Язык: Английский
Процитировано
6BMC Biotechnology, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 20, 2025
Antibiotic resistance is a growing global threat due to antibiotic overuse and limited treatment options. Multidrug-resistant bacteria, like Staphylococcus aureus Escherichia coli, increase infection complexity mortality. This study explores nanocomposite films of ZIF-8 nanoparticles Doxycycline (Dox) enhance antibacterial efficacy. In this study, composed chitosan (CS) polyethylene glycol (PEG), incorporating zeolitic imidazolate framework-8 (ZIF-8) DOX, were developed. These characterized by their morphological, mechanical, antibacterial, drug-release properties. Antibacterial efficacy was evaluated using disk diffusion, broth microdilution, checkerboard assay methods determine MICs potential synergistic effects. The demonstrated flexibility, semi-transparency, yellowish-brown hue, with containing being thicker (79 ± 0.2 μm) than those without (54 0.5 μm). tensile strength enhanced the incorporation ZIF-8, peaking at 53.12 MPa for CS-PEG-G-10% DOX-4% film. XRD analysis confirmed crystallinity distinct peaks observed each material. drug release studies revealed an initial burst followed sustained release, higher rates in acidic environments compared neutral alkaline media. film significantly activity, achieving lowest MIC values, particularly against S. (22.5 mm inhibition zone) E. coli (14 zone). Additionally, notable effect between DOX FICI values below 0.5. exhibits optimal properties, positioning it as strong candidate developing effective treatments multidrug-resistant pathogens.
Язык: Английский
Процитировано
0Materials Science and Engineering B, Год журнала: 2024, Номер 310, С. 117681 - 117681
Опубликована: Сен. 5, 2024
Язык: Английский
Процитировано
3Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Окт. 5, 2024
Язык: Английский
Процитировано
3International Journal of Biological Macromolecules, Год журнала: 2024, Номер 276, С. 133810 - 133810
Опубликована: Июль 14, 2024
Язык: Английский
Процитировано
2BioNanoScience, Год журнала: 2024, Номер 15(1)
Опубликована: Дек. 2, 2024
Язык: Английский
Процитировано
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